Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: There is provided an electrical switch comprising a length of superconducting material. In some forms the electrical switch is configured to be controlled between a low-resistance state and a higher-resistance state by the selective application of one or more switching mechanisms. In the higher-resistance state, current flowing through the length of superconducting material may approach the critical current of the length of superconducting material, may be substantially equal to the critical current or may be greater than the critical current. In some forms, the length of superconducting material is a length of high temperature superconducting material.

Abstract: In some embodiments, the present invention provides a reverse shoulder glenoid prosthesis which supports the attachment of multiple different types of modular attachments that can: 1) provide additional scapular fixation (ie external to the glenoid) in order to improve glenoid implant fixation in cases of severe bone loss/fracture, 2) provide joint line lateralization to improve tissue stability in cases of severe glenoid/scapula bone loss, 3) facilitate use and containment of glenoid bone graft in cases of severe glenoid/scapula bone loss—particularly in those cases in which the glenoid defect is uncontained/peripheral 4) achieve glenoid fixation while at the same time reconstructing the scapular bone in cases of scapula fractures, glenoid fractures, and/or acromial fractures, and 5) provide improved rTSA joint biomechanics, particularly posterior rotator cuff efficiency by changing the line of action of the infraspinatus and teres minor muscles to improve their muscle tension, and also increase each muscle'

Abstract: A docking station for a medical device is described. In some examples, the docking station includes a frame and a base plate coupled to the frame. At least a portion of the base plate is coupled to a lower portion of the frame. In some examples, an electronic connector of the docking station is configured to couple to the medical device and to provide power to the medical device when the medical device is docked to the docking station. In some examples, a docking mechanism is coupled to an upper portion of the frame and configured to retain the medical device.

Abstract: A disclosed system determines the elevation of an emulsion phase in a vessel. The system includes more than one source-detector pairs connected to the vessel and a computing device. Each of the source-detector pairs include a radioactive source and a radiometric detector, and are positioned at an elevation measured from the bottom of the vessel. The computing device is connected to the source-detector pairs, and is configured to identify the height of an emulsion phase using an upper boundary target density and a lower boundary target density. The height of the emulsion phase is identified by obtaining density readings from at least two of the source-detector pairs, calculating an upper boundary emulsion phase elevation and calculating a lower boundary emulsion phase elevation, each calculation using the density readings, and at least one of the upper boundary target density, and the lower boundary target density.

Abstract: A device may include a drum pedal board with a first end, a second end, a left side, and a right side. Further the device may include an incline section coupled to either the left side or the right side of the drum pedal board, a heel base with variable height, a hinge coupling the first end of the drum pedal board to the heel base, and a drum pedal base coupled to the heel base. The drum pedal board may be substantially parallel to the drum pedal base. The incline section may have a variable incline via a hinge. The heel base may have a variable height via a plurality of heel inserts. An adjustable strap may be operable to secure a user's foot to the drum pedal board. A raised toe section may be operable to raise an end of the drum pedal board.

Abstract: A device for wound healing or tissue repair comprising collagen and a tetracycline compound which is effective for preventing or controlling a fungal infection.

Abstract: A device may include a drum pedal board with a first end, a second end, a left side, and a right side. Further the device may include an incline section coupled to either the left side or the right side of the drum pedal board, a heel base with variable height, a hinge coupling the first end of the drum pedal board to the heel base, and a drum pedal base coupled to the heel base. The drum pedal board may be substantially parallel to the drum pedal base. The incline section may have a variable incline via a hinge. The heel base may have a variable height via a plurality of heel inserts. An adjustable strap may be operable to secure a user's foot to the drum pedal board. A raised toe section may be operable to raise an end of the drum pedal board.