Abstract: Disclosed herein are compounds and ligands, and compositions formed therewith, that modulate insulin secretion and suppress appetite by activating ectopic olfactory receptors. Also disclosed herein are methods for using the compositions to treat endocrine diseases, such as type-2 diabetes, and disorders, such as abnormal insulin secretion.

Abstract: A method and system for monitoring a user's intoxication including receiving a set of signals, derived from a set of samples collected from the user at a set of time points; providing a sobriety task to the user proximal to a time point of the set of time points; generating a performance dataset characterizing performance of the sobriety task by the user; receiving a supplementary dataset characterizing a demographic profile of the user and/or a physiological state of the user; determining a set of values of an intoxication metric, derived from the set of signals; generating a predicted temporal profile of the intoxication metric for the user based upon the set of values, the set of time points, and the supplementary dataset; generating an analysis of the user's sobriety based upon the performance dataset and the predicted temporal profile; and providing a notification to the user based upon the analysis.

Abstract: The present disclosure relates to a composition that includes a repeat unit defined by where each of R1, R2, R3, R4, R5, R6, R7, and R8 includes at least one of a hydrogen atom, a fluorine atom, and/or a first hydrocarbon chain having between 1 and 20 carbon atoms, inclusively, where each of A1, A2, A3 and A4 are either a carbon atom or a nitrogen atom, when A1 is a nitrogen atom, A2 is a carbon atom, when A2 is a nitrogen atom, A1 is a carbon atom, when A3 is a nitrogen atom, A4 is a carbon atom, when A4 is a nitrogen atom, A3 is a carbon atom, either A1 or A2 form a covalent bond, x, with a carbon atom, a, either A3 or A4 form a covalent bond, y, with a carbon atom, b, L is a linker group that includes an aromatic ring, and n is between 1 and 20, inclusively.

Abstract: Pressure sensitive key techniques are described. In one or more implementations, a device includes at least one pressure sensitive key having a flexible contact layer spaced apart from a sensor substrate by a spacer layer, the flexible contact layer configured to flex responsive to pressure to contact the sensor substrate to initiate an input, for a computing device, associated with the pressure sensitive key. At least one of the flexible contact layer or the sensor substrate are configured to at least partially normalize an output resulting from pressure applied at a first location of the flexible contact layer with an output resulting from pressure applied at a second location of the flexible contact layer that has lesser flexibility than the first location.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the control system being configured to receive an environment indication signal indicative of an environment surrounding the vehicle, the control system being configured to determine, based on the environment indication signal, whether there is a need to pre-emptively brake the vehicle before brake torque is demanded of a braking system of the vehicle and the control system being configured, when it is determined that there is a need to pre-emptively brake the vehicle, to cause the driveline to operate in a second configuration and not a first configuration, wherein in the first configuration a first group of one or more wheels are arranged to be driven by the driveline and in the second configuration the first group of one or more wheels and in addition a second group of one or more wheels are arranged to be driven by the drivel

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: The present disclosure relates to a composition that includes a repeat unit defined by where each of R1, R2, R3, R4, R5, R6, R7, and R8 includes at least one of a hydrogen atom, a fluorine atom, and/or a first hydrocarbon chain having between 1 and 20 carbon atoms, inclusively, where each of A1, A2, A3 and A4 are either a carbon atom or a nitrogen atom, when A1 is a nitrogen atom, A2 is a carbon atom, when A2 is a nitrogen atom, A1 is a carbon atom, when A3 is a nitrogen atom, A4 is a carbon atom, when A4 is a nitrogen atom, A3 is a carbon atom, either A1 or A2 form a covalent bond, x, with a carbon atom, a, either A3 or A4 form a covalent bond, y, with a carbon atom, b, L is a linker group that includes an aromatic ring, and n is between 1 and 20, inclusively.

Abstract: A control system that controls a driveline of a motor vehicle to operate in a selected one of a plurality of configurations is configured to receive a brake signal responsive to the application of a braking system. The control system causes the driveline to operate in a second configuration and not a first configuration in dependence at least in part on the brake signal. In the first configuration a first group of one or more wheels and in addition a second group of one or more wheels are arranged to be driven by the driveline, and in the second configuration the first group of one or more wheels and not the second group are arranged to be driven by the driveline.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to cause the driveline to operate in a first configuration and not a second configuration in dependence on a first set of one or more conditions, the system being further configured to override operation in the first configuration and cause the driveline to operate in the second configuration and not the first configuration in dependence on the first set of one or more conditions and in addition a second set of one or more conditions.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system comprising at least one sensor for sensing an environment ahead of the vehicle and generating a sensor signal in dependence on the environment, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the sensor signal.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: A plant nutrient delivery system comprises a sensor, an electronically actuated valve and an electronic controller. The sensor is positionable in plant growing media and operable to detect a condition of the plant growing media. The electronically actuated valve has a connection to a liquid nutrient source. The electronic controller is linked to the sensor and to the electronically actuated valve. The controller is programmed to carry out automatic demand-based nutrient delivery to the plant growing media by controlling the electronically actuated valve to turn on and off based on signals received from the sensor regarding a condition of the plant growing media, thereby causing a flow of the liquid nutrient into the plant growth media to start and to stop. Methods are also described.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the control system being configured to receive an environment indication signal indicative of an environment surrounding the vehicle, the control system being configured to determine, based on the environment indication signal, whether there is a need to pre-emptively brake the vehicle before brake torque is demanded of a braking system of the vehicle and the control system being configured, when it is determined that there is a need to pre-emptively brake the vehicle, to cause the driveline to operate in a second configuration and not a first configuration, wherein in the first configuration a first group of one or more wheels are arranged to be driven by the driveline and in the second configuration the first group of one or more wheels and in addition a second group of one or more wheels are arranged to be driven by the drivel

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: The invention relates to an electrical system for use in a vehicle. The electrical system comprises a controller and electrically operable vehicle brake means. The electrical system comprises at least one vehicle electric load including vehicle brake control means operable to selectively control the vehicle brake means to move between an engaged position in which the vehicle brake means acts to inhibit movement of the vehicle and a disengaged position in which the vehicle brake means does not act to inhibit movement of the vehicle. The electrical system also comprises first and second batteries for providing electric power to the vehicle brake means and the at least one vehicle electric load. In response to detection of a fault in the electrical system, the controller is operable to electrically isolate the second battery and the vehicle brake means from the first battery and the at least one vehicle electric load, and the vehicle brake means is configured to automatically assume the engaged position.

Abstract: Flexible hinge spine techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a brake signal responsive to the application of a braking system, the system being configured to cause the driveline to operate in a second configuration and not a first configuration in dependence at least in part on the brake signal, wherein the first configuration a first group of one or more wheels and in addition a second group of one or more wheels are arranged to be driven by the driveline and in the second configuration the first group of one or more wheels and not the second group are arranged to be driven by the driveline.

Abstract: Flexible hinge and removable attachment techniques are described. In one or more implementations, a flexible hinge is configured to communicatively and physically couple an input device to a computing device and may implement functionality such as a support layer and minimum bend radius. The input device may also include functionality to promote a secure physical connection between the input device and the computing device. One example of this includes use of one or more protrusions that are configured to be removed from respective cavities of the computing device along a particular axis but mechanically bind along other axes. Other techniques include use of a laminate structure to form a connection portion of the input device.

Abstract: Input device manufacture techniques are described. In one or more implementations, a plurality of layers of a key assembly is positioned in a fixture such that one or more projections of the fixture are disposed through one or more openings in each of the one or more layers. The positioned plurality of layers is secured to each other.

Abstract: Pressure sensitive key techniques are described. In one or more implementations, a device includes at least one pressure sensitive key having a flexible contact layer spaced apart from a sensor substrate by a spacer layer, the flexible contact layer configured to flex responsive to pressure to contact the sensor substrate to initiate an input, for a computing device, associated with the pressure sensitive key. At least one of the flexible contact layer or the sensor substrate are configured to at least partially normalize an output resulting from pressure applied at a first location of the flexible contact layer with an output resulting from pressure applied at a second location of the flexible contact layer that has lesser flexibility than the first location.