Abstract: Systems and methods for managing an inspection path of an unmanned inspection device. The method begins with generating a randomized time for a UAV inspection path using a randomizing time function. Next, predicted inspection path information is accessed for the randomized time of the UAV inspection path. An inspection path is generated for the randomized time based on the predicted inspection path information accessed. A UAV is programmed to traverse the inspection path. Before the UAV departs, the system confirms the current predicted inspection path information compared to one or more of the predicted inspection path information. In response, the current predicted inspection path information is with a threshold level of the predicted inspection path information or the predicted inspection path was last inspected more than a given time period, initiating operation of the UAV to traverse the inspection path, and otherwise, generating a new randomized time and new inspection path.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: CRISPR/CAS-related genome editing systems, compositions and methods for targeting the TGFBR2 locus, as well as cells edited using these systems, compositions and methods are provided.

Abstract: Provided herein are engineered immune cells, e.g. T cells, expressing a chimeric receptor comprising an intracellular region comprising a CD3zeta (CD3?) signaling domain. In some embodiments, the engineered immune cells contain a modified CD247 locus that encodes the chimeric receptor or a portion thereof. In some embodiments, at least a portion of a CD3zeta chain encoded by CD247 genomic locus. Also provided are cell compositions containing the engineered immune cells, nucleic acids for engineering cells, and methods, kits and articles of manufacture for producing the engineered cells, such as by targeting a transgene encoding a portion of a chimeric receptor for integration into a region of a CD247 genomic locus. In some embodiments, the engineered cells, e.g. T cells, can be used in connection with cell therapy, including in connection with cancer immunotherapy comprising adoptive transfer of the engineered cells.

Abstract: Provided herein are engineered immune cells, e.g. T cells, expressing a recombinant receptor, that contain a modified transforming growth factor-beta receptor type-2 (TGFBR2) locus encoding the recombinant receptor or a portion thereof. In some aspects, the cells are engineered by targeted integration of a transgene sequence encoding the recombinant receptor or a portion thereof, at a TGFBR2 genomic locus. Also provided are cell compositions containing the engineered immune cells, nucleic acids for engineering cells, and methods, kits and articles of manufacture for producing the engineered cells, such as by targeting a transgene sequence encoding a recombinant receptor or a portion thereof for integration into a region of a TGFBR2 genomic locus. In some embodiments, the engineered cells, e.g. T cells, can be used in connection with cell therapy, including in connection with cancer immunotherapy comprising adoptive transfer of the engineered cells.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: Systems and methods for dispensing a viscous fluid using an apparatus that may include: a housing; an applicator coupling on the housing that can releasably couple an applicator that contains a viscous fluid; a gas supply coupling that receives a pressurized gas from a gas supply; a valve having a first open position in which the valve can be gradually and controllably opened to adjustably control the delivery of pressurized gas to the applicator coupling, and a second closed position where the pressurized gas delivered to the applicator coupling is vented; and a valve actuator configured to permit a user to gradually and controllably open the valve to controllably dispense the viscous fluid from the applicator, where ceasing to depress the valve actuator vents the applicator coupling and immediately discontinues the dispensing of viscous fluid from the applicator.

Abstract: Provided are methods for engineering immune cells, cell compositions containing engineered immune cells, kits and articles of manufacture for targeting nucleic acid sequence encoding a recombinant receptor to a particular genomic locus and/or for modulating expression of the gene at the genomic locus, and applications thereof in connection with cancer immunotherapy comprising adoptive transfer of engineered T cells. These may involve genetic disruption of at least one site within a TRAC gene and/or a TRBC gene and integration of the transgene encoding for the recombinant receptor at or near one of the at least one target site.

Abstract: Provided herein are methods for engineering immune cells, cell compositions containing engineered immune cells, kits and articles of manufacture for targeting nucleic acid sequence encoding a portion of a recombinant receptor, e.g., a recombinant T cell receptor (TCR), to a particular genomic locus and/or for modulating expression of the gene at the genomic locus, and applications thereof in connection with cancer immunotherapy, such as adoptive transfer of engineered T cells. In some aspects, the nucleic acid sequence integrates in-frame into the locus of a receptor encoding gene, and in some aspects, results in expression of the whole recombinant receptor.

Abstract: A system for controlling an environment within a fuel tank is provided. The system includes a conduit with a plurality of vents, wherein the conduit defines a path through the fuel tank, and wherein the conduit is configured to direct a flow of air along the path and out the plurality of vents.

Abstract: A liquid sealant applicator system that may include a liquid sealant applicator having a coupling to reversibly connect to a source of liquid sealant, a sidewall extending from the coupling and defining a sealant flow path, a flow restrictor that restricts the sealant flow path to an annular pattern of apertures in the flow restrictor, a porous matrix that fills at least a portion of the sealant flow path downstream of the flow restrictor, a matrix retainer configured to retain the porous matrix within the sealant flow path, and a fastener socket connected to the sidewall and having a distal end configured to be placed over and at least substantially enclose the head of a preselected fastener. The applicator is configured to provide a uniform application of sealant from the source of the liquid sealant to the head of the fastener enclosed by the fastener socket.

Abstract: A method of making a preformed seal includes coupling first and second sections of a mold to define a mold cavity. A cross-sectional shape of the mold cavity corresponds to a cross-sectional shape of the preformed seal. The method also includes providing a reservoir that has a port in flow communication with a reservoir cavity that extends to a parting surface. The method further includes filling the reservoir cavity with wet sealant such that the wet sealant is flush with the parting surface and a bead of wet sealant protrudes from the port. Additionally, the method includes coupling the reservoir to the first and second sections such that the reservoir cavity is in flow communication with the mold cavity at the parting surface, injecting wet sealant from a nozzle through the reservoir into the mold cavity, and curing the wet sealant in the mold cavity to make the preformed seal.

Abstract: A system for controlling an environment within a fuel tank is provided. The system includes a conduit with a plurality of vents, wherein the conduit defines a path through the fuel tank, and wherein the conduit is configured to direct a flow of air along the path and out the plurality of vents.

Abstract: Systems and methods for dispensing a viscous fluid using an apparatus that may include: a housing; an applicator coupling on the housing that can releasably couple an applicator that contains a viscous fluid; a gas supply coupling that receives a pressurized gas from a gas supply; a valve having a first open position in which the valve can be gradually and controllably opened to adjustably control the delivery of pressurized gas to the applicator coupling, and a second closed position where the pressurized gas delivered to the applicator coupling is vented; and a valve actuator configured to permit a user to gradually and controllably open the valve to controllably dispense the viscous fluid from the applicator, where ceasing to depress the valve actuator vents the applicator coupling and immediately discontinues the dispensing of viscous fluid from the applicator.

Abstract: A system for controlling an environment within a fuel tank is provided. The system includes a conduit with a plurality of vents, wherein the conduit defines a path through the fuel tank, and wherein the conduit is configured to direct a flow of air along the path and out the plurality of vents.

Abstract: The present invention generally relates to a ring assembly that may be used in an etching or other plasma processing chamber. The ring assembly generally includes an inner ring body having a top planar surface and a bottom planar surface, and an outer ring body having a top surface, a bottom surface substantially parallel to the top surface, and an inside surface that extends between the top surface and the bottom surface, the inside surface having a roof covering a portion of the inner ring body when the inner ring body is disposed adjacent the roof, wherein the inner ring body can be flipped into a different position so that a portion of the inner ring body that is not covered by the roof provides a substantially planar surface.

Abstract: A liquid sealant applicator system that may include a liquid sealant applicator having a coupling to reversibly connect to a source of liquid sealant, a sidewall extending from the coupling and defining a sealant flow path, a flow restrictor that restricts the sealant flow path to an annular pattern of apertures in the flow restrictor, a porous matrix that fills at least a portion of the sealant flow path downstream of the flow restrictor, a matrix retainer configured to retain the porous matrix within the sealant flow path, and a fastener socket connected to the sidewall and having a distal end configured to be placed over and at least substantially enclose the head of a preselected fastener. The applicator is configured to provide a uniform application of sealant from the source of the liquid sealant to the head of the fastener enclosed by the fastener socket.