Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A prosthesis alignment guide includes a guide body that has an opening that extends at least partially therein and a first alignment hole extending entirely therethrough. The opening is configured to receive a trunnion of a joint prosthesis for mounting the guide body to the joint prosthesis. An alignment member is disposed within the first alignment hole and is axially moveable therein. A locking member is engaged to the guide body and moveable from a first position in which the locking member is disengaged from the alignment member and a second position in which the locking member engages the alignment member and secures it from axial movement within the first alignment hole.

Abstract: A golf ball teeing device comprising, a platform having an upper surface, an opening in the platform, a tee for a golf ball the tee being arranged for reciprocal movement with respect to the opening between a lower position where the top of the tee is at a level below the upper surface of the platform to an upper position where the top of the tee is above upper surface of the platform, and golf ball deliver means arranged to load a golf ball on top of the tee when it is in the lower position, wherein the golf ball is at a level below the upper surface of the platform when it is loaded onto the tee by the golf ball delivery means.