Abstract: The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.

Abstract: The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.

Abstract: The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.

Abstract: The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.

Abstract: The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.

Abstract: The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.

Abstract: The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.

Abstract: A method used to detect and identify biological substances suspended in air in the form of aerosols or clouds including generating a remote infrared light beam directed toward the atmospheric contamination, producing an ultraviolet light beam from the infrared light beam by compression via the air through which the IR beam travels, and producing fluorescence of the atmospheric contamination, when the generated ultraviolet light contacts the atmospheric contamination. The fluorescent signals are then processed in order to identify the nature of the atmospheric contamination.

Abstract: A system for detecting atmospheric contamination, the system comprising a laser operable to generate an infrared light beam comprising a longitudinal component and a transverse component the laser remote from the atmospheric contamination, and a processor operable to process a flouresence resulting from contact between the atmospheric contamination and an ultraviolet light being generated from the longitudinal and transverse components of the infrared light of the laser, wherein the processor determines the identity of the fluorescence by comparing the fluorescence to known fluorescence.

Abstract: A method used to detect and identify biological substances suspended in air in the form of aerosols or clouds including generating a remote infrared light beam directed toward the atmospheric contamination, producing an ultraviolet light beam from the infrared light beam by compression via the air through which the IR beam travels, and producing fluorescence of the atmospheric contamination, when the generated ultraviolet light contacts the atmospheric contamination. The fluorescent signals are then processed in order to identify the nature of the atmospheric contamination.