Patents by Inventor Christopher J. Buchko
Christopher J. Buchko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20100173065Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.Type: ApplicationFiled: January 6, 2010Publication date: July 8, 2010Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventors: Eugene T. Michal, Ni Ding, Christopher J. Buchko
-
Patent number: 7736906Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodologies.Type: GrantFiled: June 17, 2002Date of Patent: June 15, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 7691330Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: May 26, 2000Date of Patent: April 6, 2010Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 7682669Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.Type: GrantFiled: July 30, 2001Date of Patent: March 23, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Ni Ding, Christopher J. Buchko
-
Patent number: 6943034Abstract: A method for producing arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a compound in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the compound to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: February 4, 2000Date of Patent: September 13, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6864101Abstract: A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 polymer ligands at a density of 1000 per cm2 or greater.Type: GrantFiled: May 26, 2000Date of Patent: March 8, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6849462Abstract: A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.Type: GrantFiled: May 26, 2000Date of Patent: February 1, 2005Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Publication number: 20040235033Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.Type: ApplicationFiled: May 14, 2004Publication date: November 25, 2004Applicant: Affymetrix, Inc.Inventors: Alejandro C. Zaffaroni, Christopher J. Buchko, Douglas N. Modlin
-
Publication number: 20040092032Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: ApplicationFiled: June 17, 2002Publication date: May 13, 2004Applicant: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P.A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6656517Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.Type: GrantFiled: July 25, 2001Date of Patent: December 2, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
-
Patent number: 6544543Abstract: Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically effective amount of a vasoconstrictor. It is anticipated these brief periods of occlusion will induce the enlargement of collateral vessels, causing increased blood flow to the ischemic region.Type: GrantFiled: December 27, 2000Date of Patent: April 8, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Evgenia Mandrusov, Christopher J. Buchko, Wouter E. Roorda
-
Patent number: 6541116Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.Type: GrantFiled: April 6, 2001Date of Patent: April 1, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Christopher J. Buchko, Deborah L. Kilpatrick, Stephen J. Bigus
-
Publication number: 20020187288Abstract: A medical device, and particularly an intracorporeal device for therapeutic or diagnostic use, comprising a silicone polyurethane. One embodiment of the invention is a medical device having a body formed of melt process extruded, porous silicone polyurethane material. In a method of the invention, the silicone polyurethane is combined with a porogen and then melt process extruded into a desired shape such as a tubular body. The porogen is then extracted from the extrudate, to form the extruded, melt processed, porous silicone polyurethane tubular body. The medical device, such as a stent cover, vascular graft, or catheter balloon, formed of the silicone polyurethane has excellent biostability, strength, and flexibility.Type: ApplicationFiled: June 11, 2001Publication date: December 12, 2002Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Florencia Lim, Christopher J. Buchko, Ashok A. Shah, Murthy V. Simhambhatla
-
Publication number: 20020151085Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.Type: ApplicationFiled: April 3, 2002Publication date: October 17, 2002Inventors: Alejandro C. Zaffaroni, Christopher J. Buchko, Douglas N. Modlin
-
Publication number: 20020119578Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.Type: ApplicationFiled: April 3, 2002Publication date: August 29, 2002Inventors: Alejandro C. Zaffaroni, Christopher J. Buchko, Douglas N. Modlin
-
Publication number: 20020009535Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.Type: ApplicationFiled: April 6, 2001Publication date: January 24, 2002Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Christopher J. Buchko, Deborah L. Kilpatrick, Stephen J. Bigus
-
Publication number: 20020002353Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.Type: ApplicationFiled: July 25, 2001Publication date: January 3, 2002Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
-
Patent number: 6287285Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.Type: GrantFiled: January 29, 1999Date of Patent: September 11, 2001Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
-
Patent number: 6136269Abstract: A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: April 21, 1995Date of Patent: October 24, 2000Assignee: Affymetrix, Inc.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 6121048Abstract: An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the compounds of the array are located. Surrounding the cells is a non-wetable surface that prevents the solution in one cell from moving to adjacent cells. The compounds are delivered to the individual cells of the array by a micropipette attached to an X-Y translation stage.Type: GrantFiled: October 18, 1994Date of Patent: September 19, 2000Inventors: Alejandro C. Zaffaroni, Christopher J. Buchko, Douglas N. Modlin