Patents by Inventor Christopher J. Burns

Christopher J. Burns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Penicillin-binding protein inhibitors
    Patent number: 11267826
    Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: March 8, 2022
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Denis Daigle, Guo-Hua Chu, Randy W. Jackson, Jodie Hamrick, Matthew Lucas, Steven A. Boyd, Jiangchao Yao, Eugen F. Mesaros
  • COMBINATION COMPOSITIONS COMPRISING A BETA-LACTAMASE INHIBITOR
    Publication number: 20220054513
    Abstract: Described herein are combination compositions comprising a beta-lactamase inhibitor. In certain embodiments, the combination compositions described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 24, 2022
    Inventors: Jodie HAMRICK, Christopher J. BURNS, Daniel C. PEVEAR, Luigi XERRI, Timothy HENKEL, Denis DAIGLE
  • Hepatitis B capsid assembly modulators
    Patent number: 11247965
    Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: February 15, 2022
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Glen Coburn, Bin Liu, Jiangchao Yao, Christopher Benetatos, Steven A. Boyd, Stephen M. Condon
  • SOLID FORMS AND COMBINATION COMPOSITIONS COMPRISING A BETA-LACTAMASE INHIBITOR AND USES THEREOF
    Publication number: 20220002322
    Abstract: Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.
    Type: Application
    Filed: June 21, 2021
    Publication date: January 6, 2022
    Inventors: Christopher J. BURNS, Daniel C. PEVEAR, Luigi XERRI, Timothy HENKEL, Daniel MCGARRY, Lawrence ROSEN, Gerald BRENNER, Jean-Baptiste ARLIN, Ana FERNANDEZ CASARES
  • Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof
    Patent number: 11091505
    Abstract: Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: August 17, 2021
    Assignee: VenatoRx Pharmaceuticals, Inc.
    Inventors: Christopher J. Burns, Daniel C. Pevear, Luigi Xerri, Timothy Henkel, Daniel McGarry, Lawrence Rosen, Gerald Brenner, Jean-Baptiste Arlin, Ana Fernandez Casares
  • PENICILLIN-BINDING PROTEIN INHIBITORS
    Publication number: 20210198288
    Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 1, 2021
    Inventors: Christopher J. BURNS, Denis DAIGLE, Guo-Hua CHU, Jodie HAMRICK, Steven A. BOYD, Allison L. ZULLI, Eugen F. MESAROS, Stephen M. CONDON, Robert E. Lee TROUT, Cullen L. MYERS, Zhenrong XU
  • Beta-lactamase inhibitors
    Patent number: 11046716
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 29, 2021
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Bin Liu, Jiangchao Yao, Denis Daigle, Steven A. Boyd
  • BROAD-SPECTRUM CARBAPENEMS
    Publication number: 20210188851
    Abstract: The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.
    Type: Application
    Filed: May 29, 2019
    Publication date: June 24, 2021
    Inventors: Christopher J. BURNS, Guo-Hua CHU, Jodie HAMRICK, Steven A. Boyd, Stephen M. CONDON
  • HEPATITIS B CAPSID ASSEMBLY MODULATORS
    Publication number: 20210171439
    Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 10, 2021
    Applicant: VenatoRx Pharmaceuticals, Inc.
    Inventors: Christopher J. BURNS, Glen COBURN, Bin LIU, Jiangchao YAO, Christopher BENETATOS, Steven A. Boyd, Stephen M. CONDON
  • Hepatitis B capsid assembly modulators
    Patent number: 11014881
    Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: May 25, 2021
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Glen Coburn, Bin Liu, Jiangchao Yao, Christopher Benetatos, Steven A. Boyd, Stephen M. Condon, Thomas Haimowitz
  • Beta-lactamase inhibitors
    Patent number: 11008346
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: May 18, 2021
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Denis Daigle, Bin Liu, Randy W. Jackson, Jodie Hamrick, Daniel McGarry, Daniel C. Pevear, Robert E. Lee Trout
  • BETA-LACTAMASE INHIBITORS
    Publication number: 20200361962
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: February 21, 2020
    Publication date: November 19, 2020
    Inventors: Christopher J. BURNS, Denis DAIGLE, Bin LIU, Randy W. JACKSON, Jodie HAMRICK, Daniel McGARRY, Daniel C. PEVEAR, Robert E. Lee TROUT
  • BETA-LACTAMASE INHIBITORS
    Publication number: 20200317698
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: May 1, 2020
    Publication date: October 8, 2020
    Inventors: Christopher J. BURNS, Denis DAIGLE, Bin LIU, Daniel McGARRY, Daniel C. PEVEAR, Robert E. Lee TROUT, Randy W. JACKSON
  • Beta-lactamase inhibitors
    Patent number: 10669290
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: June 2, 2020
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Denis Daigle, Bin Liu, Daniel McGarry, Daniel C. Pevear, Robert E. Lee Trout
  • PENICILLIN-BINDING PROTEIN INHIBITORS
    Publication number: 20200157123
    Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 21, 2020
    Inventors: Christopher J. BURNS, Denis DAIGLE, Guo-Hua CHU, Jodie HAMRICK, Matthew LUCAS, Steven A. Boyd, Allison L. ZULLI, Eugen F. MESAROS, Stephen M. CONDON, Robert E. Lee TROUT, Cullen L. MYERS
  • HEPATITIS B CAPSID ASSEMBLY MODULATORS
    Publication number: 20200123105
    Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
    Type: Application
    Filed: November 1, 2019
    Publication date: April 23, 2020
    Inventors: Christopher J. BURNS, Glen COBURN, Bin LIU, Jiangchao YAO, Christopher BENETATOS, Steven A. BOYD, Stephen M. CONDON, Thomas HAIMOWITZ
  • PENICILLIN-BINDING PROTEIN INHIBITORS
    Publication number: 20200102331
    Abstract: Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: May 25, 2018
    Publication date: April 2, 2020
    Inventors: Christopher J. BURNS, Denis DAIGLE, Guo-Hua CHU, Randy W. JACKSON, Jodie HAMRICK, Matthew Lucas, Steven A. BOYD, Jiangchao YAO, Eugen F. MESAROS
  • Hepatitis B capsid assembly modulators
    Patent number: 10590076
    Abstract: Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: March 17, 2020
    Assignee: VENATORX PHARMACEUTICALS, INC.
    Inventors: Christopher J. Burns, Glen Coburn, Bin Liu, Jiangchao Yao, Christopher Benetatos, Steven A. Boyd, Stephen M. Condon, Thomas Haimowitz
  • BETA-LACTAMASE INHIBITORS
    Publication number: 20200055877
    Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
    Type: Application
    Filed: July 17, 2019
    Publication date: February 20, 2020
    Inventors: Christopher J. BURNS, Bin LIU, Jiangchao YAO, Denis DAIGLE, Steven A. BOYD
  • SOLID FORMS AND COMBINATION COMPOSITIONS COMPRISING A BETA-LACTAMASE INHIBITOR AND USES THEREOF
    Publication number: 20200010485
    Abstract: Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.
    Type: Application
    Filed: March 5, 2018
    Publication date: January 9, 2020
    Inventors: Christopher J. BURNS, Daniel C. PEVEAR, Luigi XERRI, Timothy HENKEL, Daniel MCGARRY, Lawrence ROSEN, Gerald BRENNER, Jean-Baptiste ARLIN, Ana FERNANDEZ CASARES