Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A melt-blown fabric for pouching smokeless tobacco or a smokeless tobacco substitute can include melt-blown polymer fibers. The fabric can have a basis weight of less than 30 gsm and a tensile strength of at least 4mJ in at least one predetermined direction. Method of making the fabric can include melt-blowing a polymeric material against a support surface and bonding the fibers or arranging them in a predetermined orientation. Pouched smokeless tobacco or tobacco substitute products including the fabrics provided herein can provide desirable flavor and tactile experience.

Abstract: Disclosed embodiments may relate to dressings configured to provide negative-pressure wound therapy to a tissue site, while simultaneously shielding a portion of the tissue site from the negative pressure. For example, dressing assembly embodiments may comprise an outer dressing configured for applying negative-pressure wound therapy to a tissue site, and an underlying isolation patch configured for use under the outer dressing. The isolation patch may be configured to seal the portion of the tissue site so that it does not experience the negative pressure. Additionally disclosed are other apparatus, dressings, systems, and methods.

Abstract: Disclosed embodiments may relate to dressings configured to provide negative-pressure wound therapy to a tissue site, while simultaneously shielding a portion of the tissue site from the negative pressure. For example, dressing assembly embodiments may comprise an outer dressing configured for applying negative-pressure wound therapy to a tissue site, and an underlying isolation patch configured for use under the outer dressing. The isolation patch may be configured to seal the portion of the tissue site so that it does not experience the negative pressure. Additionally disclosed are other apparatus, dressings, systems, and methods.

Abstract: Disclosed embodiments may relate to dressings configured to provide negative-pressure wound therapy to a tissue site, while simultaneously shielding a portion of the tissue site from the negative pressure. For example, dressing assembly embodiments may comprise an outer dressing configured for applying negative-pressure wound therapy to a tissue site, and an underlying isolation patch configured for use under the outer dressing. The isolation patch may be configured to seal the portion of the tissue site so that it does not experience the negative pressure. Additionally disclosed are other apparatus, dressings, systems, and methods.

Abstract: In some examples, a dressing suitable for treating a tissue site may include a fluid management assembly configured to offload fluid extracted from the tissue site away from an articulation area at the tissue site. Other features may be associated with the dressing including, without limitation, a base layer, an adhesive, one or more wicking layers, and an absorbent layer. Other dressings, apparatus, systems, and methods are disclosed.

Abstract: In some examples, a dressing suitable for treating a tissue site may include a fluid management assembly including a fluid restraint configured to reduce a fluid capacity of the fluid management assembly proximate to the fluid restraint. Other features may be associated with the dressing including, by way of example and without limitation, abase layer, an adhesive, one or more wicking layers, and an absorbent layer. Other dressings, apparatus, systems, and methods are disclosed.

Abstract: A dice angle game is played on an apparatus that has a playing surface, at least one side wall, at least one barrier within the playing area, at least one demarcated scoring area, at least one enhanced scoring area of sufficient size for at least one die to enter, and a plurality of dice. The game is played by rolling a dice against a side wall and trying to have it land in a scoring area.

Abstract: A dice angle game is played on an apparatus that has a playing surface, at least one side wall, at least one barrier within the playing area, at least one demarcated scoring area, at least one enhanced scoring area of sufficient size for at least one die to enter, and a plurality of dice. The game is played by rolling a dice against a side wall and trying to have it land in a scoring area.

Abstract: A dice angle game is played on an apparatus that preferably has a flat playing surface, two side walls, two end walls, two barriers, scoring areas between the barriers and the adjacent end walls, and a plurality of dice. The game is played by rolling a dice against a side wall and trying to have it land in a scoring area.

Abstract: Disclosed is a technique for storing a count of incrementally increasing data exclusively in EEPROM using semaphores to avoid significant losses, as a result of power downs, greater than a single least significant bit in accuracy. The disclosed embodiment includes a first EEPROM register, comprised of 256 bits, for storing 256 incremental count increases, each bit is used to record an incremental count increase. A pair of 16 bit EEPROM registers is provided for incrementally storing updated count information in response to the first EEPROM register overflowing. Semaphores are provided for indicating whether or not the incrementally increasing count information has been at least partially stored in the pair of registers. Once an overflow from the first register is detected, the semaphores are checked to determine in what stage the update to the pair of registers was left (in case of power down).