Abstract: The present disclosure relates generally to novel lipid nanoparticle (LNP)-based compositions useful for, e.g., the delivery of a site-specific endonuclease or a nucleic acid molecule encoding same, into a target cell. Some embodiments of the disclosure relate to compositions and methods for editing the genome of a cell, which involve contacting the cell with an LNP composition as described herein.

Abstract: The present disclosure relates generally to novel lipid nanoparticle (LNP)-based compositions useful for, e.g., the delivery of a site-specific endonuclease or a nucleic acid molecule encoding same, into a target cell. Some embodiments of the disclosure relate to compositions and methods for editing the genome of a cell, which involve contacting the cell with an LNP composition as described herein.

Abstract: Activated polymers comprising one or more backbone ester(s) are disclosed. In particular, activated poly(amine-co-ester) (aPACE) terpolymers and methods of making and using these aPACE terpolymers are disclosed. These aPACE terpolymers can be used to safely and efficiently deliver biomolecules, in particular nucleic acids, to cells, both in vitro and in vivo. Methods for making activated polymers are also provided. Furthermore, methods for delivering mRNA and methods of gene therapy using activated polymers, in vitro and/or in vivo are further disclosed.

Abstract: A system is provided for limiting distortion of an audio speaker. The system includes a first lowpass filter circuitry that is configured to receive a system input signal and generate a first lowpass filtered output signal. The system also includes a first limiter circuitry that is configured to limit the first lowpass filtered output signal. Limiting the first low pass filtered output signal includes reducing an amplitude of the first lowpass filtered output signal below a first predetermined threshold value, thereby to generate a first limited output signal. A second lowpass filter circuitry is configured to receive the first limited output signal and to generate a second lowpass filtered output signal.

Abstract: A solid piston having a closed shape is attached to a solid support surrounding the piston and corresponding in shape to the shape of the piston by a layer of compliant material adhered to a top surface of the piston and a top surface of the support. The layer of compliant material includes an open central area exposing the top surface of the piston through the open area. An assembly for an electroacoustic transducer includes a piston, which is an elliptical plate of silicon having a flat top surface and serving as the diaphragm, an elliptical support ring of silicon surrounding the piston and separated from the piston by a gap, and a layer of compliant material adhered to a top surface of the support ring and to the top surface of the piston, suspending the piston in the gap. An elliptical or cylindrical motor is coupled to the piston.

Abstract: A system is provided for limiting distortion of an audio speaker. The system includes a first lowpass filter circuitry that is configured to receive a system input signal and generate a first lowpass filtered output signal. The system also includes a first limiter circuitry that is configured to limit the first lowpass filtered output signal. Limiting the first low pass filtered output signal includes reducing an amplitude of the first lowpass filtered output signal below a first predetermined threshold value, thereby to generate a first limited output signal. A second lowpass filter circuitry is configured to receive the first limited output signal and to generate a second lowpass filtered output signal.

Abstract: A system is provided for limiting distortion of an audio speaker. The system includes a first lowpass filter circuitry that is configured to receive a system input signal and generate a first lowpass filtered output signal. The system also includes a first limiter circuitry that is configured to limit the first lowpass filtered output signal. Limiting the first low pass filtered output signal includes reducing an amplitude of the first lowpass filtered output signal below a first predetermined threshold value, thereby to generate a first limited output signal. A second lowpass filter circuitry is configured to receive the first limited output signal and to generate a second lowpass filtered output signal.

Abstract: A system is provided for limiting distortion of an audio speaker. The system includes a first lowpass filter circuitry that is configured to receive a system input signal and generate a first lowpass filtered output signal. The system also includes a first limiter circuitry that is configured to limit the first lowpass filtered output signal. Limiting the first low pass filtered output signal includes reducing an amplitude of the first lowpass filtered output signal below a first predetermined threshold value, thereby to generate a first limited output signal. A second lowpass filter circuitry is configured to receive the first limited output signal and to generate a second lowpass filtered output signal.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: A method for determining leakage factors or adaptation rates, or both, for adaptive filters in an active noise reduction system. The leakage factor or adaptation rate, or both, may vary depending on a parameter of an input reference signal. The parameter may include one or more of reference signal input frequency, rate of change of reference input signal frequency, if a predetermined triggering condition exits, or if a predetermined event has occurred.

Abstract: A method for determining leakage factors or adaptation rates, or both, for adaptive filters in an active noise reduction system. The leakage factor or adaptation rate, or both, may vary depending on a parameter of an input reference signal. The parameter may include one or more of reference signal input frequency, rate of change of reference input signal frequency, if a predetermined triggering condition exits, or if a predetermined event has occurred.

Abstract: A method for determining leakage factors or adaptation rates, or both, for adaptive filters in an active noise reduction system. The leakage factor or adaptation rate, or both, may vary depending on a parameter of an input reference signal. The parameter may include one or more of reference signal input frequency, rate of change of reference input signal frequency, if a predetermined triggering condition exits, or if a predetermined event has occurred.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: A method for determining leakage factors or adaptation rates, or both, for adaptive filters in an active noise reduction system. The leakage factor or adaptation rate, or both, may vary depending on a parameter of an input reference signal. The parameter may include one or more of reference signal input frequency, rate of change of reference input signal frequency, if a predetermined triggering condition exits, or if a predetermined event has occurred.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: An active noise reduction system using adaptive filters. A method of operation the active noise reduction system includes smoothing a stream of leakage factors. The frequency of a noise reduction signal may be related to the engine speed of an engine associated with the system within which the active noise reduction system is operated. The engine speed signal may be a high latency signal and may be obtained by the active noise reduction system over audio entertainment circuitry.

Abstract: A system and method interpolates a full color image from an array of single color sensors. Each sensor measures a single color, e.g., red, green or blue. The measured color values are stored as an array of data. For each data element, a plurality, e.g., four, gradients are computed that specify the color and/or luminance difference along different linear paths extending through the data element. At least some of the gradients are computed using a first order color differential and a second order color or luminance differential along the selected path. One or more gradients are then selected based on a comparison of the gradients to a computed threshold. Using the data elements along the path of the selected gradient or gradients, the missing color values are interpolated. The interpolation algorithm also utilizes first and second order color differentials.

Abstract: A system and method interpolates a full color image from an array of single color sensors. Each sensor measures a single color, e.g., red, green or blue. The measured color values are stored as an array of data. For each data element, a plurality, e.g., four, gradients are computed that specify the color and/or luminance difference along different linear paths extending through the data element. At least some of the gradients are computed using a first order color differential and a second order color or luminance differential along the selected path. One or more gradients are then selected based on a comparison of the gradients to a computed threshold. Using the data elements along the path of the selected gradient or gradients, the missing color values are interpolated. The interpolation algorithm also utilizes first and second order color differentials.