Patents by Inventor Christopher J. Elkins
Christopher J. Elkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230018570Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: ApplicationFiled: July 14, 2021Publication date: January 19, 2023Inventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: 7486166Abstract: The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetic or magnetizable molecular structures and targets. Also disclosed are further improvements to aspects of the hybrid magnetic structure, including additional elements and for adapting the use of the hybrid magnetic structure for use in biotechnology and high throughput processes.Type: GrantFiled: November 9, 2006Date of Patent: February 3, 2009Assignee: The Regents of the University of CaliforniaInventors: David E. Humphries, Martin J. Pollard, Christopher J. Elkin
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Patent number: 7148778Abstract: The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides for separation and other biotechnology applications involving holding, manipulation, or separation of magnetic or magnetizable molecular structures and targets. Also disclosed are: a method of assembling the hybrid magnetic plates, a high throughput protocol featuring the hybrid magnetic structure, and other embodiments of the ferromagnetic pole shape, attachment and adapter interfaces for adapting the use of the hybrid magnetic structure for use with liquid handling and other robots for use in high throughput processes.Type: GrantFiled: October 11, 2005Date of Patent: December 12, 2006Assignee: The Regents of the University of CaliforniaInventors: David E. Humphries, Martin J. Pollard, Christopher J. Elkin
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Patent number: 7056339Abstract: A stent based drug delivery system. A biological agent of interest is entrapped within a matrix, which is loaded into channels on the surface of a stent. The matrix allows for release, usually sustained release, of the entrapped agent. The stent and matrix is sheathed with a covalently bound gel. In one embodiment of the invention, the stent is used to deliver therapeutic agents to a patient, providing the advantage of efficient delivery and sustained release of an agent at a localized site. In another embodiment of the invention, the drug delivery system is used for testing and comparison of candidate drugs in an in vivo setting.Type: GrantFiled: March 11, 2002Date of Patent: June 6, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Christopher J. Elkins, Michael D. Dake, Jacob M. Waugh
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Patent number: 7048939Abstract: Restenosis is inhibited through local delivery of anti-restenotic agents including angiotensin converting enzyme inhibitors; nicotine receptor agonists, agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors. In one embodiment of the invention, the localized delivery is effected through the use of a stent modified for delivery of the agent at the site of injury from balloon angioplasty.Type: GrantFiled: March 11, 2002Date of Patent: May 23, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Christopher J. Elkins, Michael D. Dake, Jacob M. Waugh
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Patent number: 6954128Abstract: The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are: a method of assembling the hybrid magnetic plates, a high throughput protocol featuring the hybrid magnetic structure, and other embodiments of the ferromagnetic pole shape, attachment and adapter interfaces for adapting the use of the hybrid magnetic structure for use with liquid handling and other robots for use in high throughput processes.Type: GrantFiled: November 26, 2002Date of Patent: October 11, 2005Assignee: The Regents of the University of CaliforniaInventors: David E Humphries, Martin J Pollard, Christopher J Elkin
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Patent number: 6947862Abstract: A method for determining the flow of a fluid (60) in a gap (64) between a pad (48) and a substrate (12) includes the step of utilizing a hybrid Navier-Stokes/lubrication formulation to calculate the flow of the fluid (60) in the gap (64) at a plurality of time steps. The gap (64) can be divided into a plurality of elements (700). The hybrid Navier-Stokes/lubrication formulation can be used to calculate the fluid flow and the pressure of the fluid (60) at each element (700) at the plurality of time steps. Additionally, a method for tracking and estimating the composition of the fluid (60) at various locations in the gap (64) and a material removal rate model that attempts to account for the effects of the fluid flow in the gap (64), the hydrostatic pressure in the gap (64) and the composition of the fluid (60) in the gap (64) are provided herein.Type: GrantFiled: February 14, 2003Date of Patent: September 20, 2005Assignee: Nikon CorporationInventors: John K. Eaton, Christopher J. Elkins, Tristan M. Burton
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Publication number: 20040162688Abstract: A method for determining the flow of a fluid (60) in a gap (64) between a pad (48) and a substrate (12) includes the step of utilizing a hybrid Navier-Stokes/lubrication formulation to calculate the flow of the fluid (60) in the gap (64) at a plurality of time steps. The gap (64) can be divided into a plurality of elements (700). The hybrid Navier-Stokes/lubrication formulation can be used to calculate the fluid flow and the pressure of the fluid (60) at each element (700) at the plurality of time steps. Additionally, a method for tracking and estimating the composition of the fluid (60) at various locations in the gap (64) and a material removal rate model that attempts to account for the effects of the fluid flow in the gap (64), the hydrostatic pressure in the gap (64) and the composition of the fluid (60) in the gap (64) are provided herein.Type: ApplicationFiled: February 14, 2003Publication date: August 19, 2004Inventors: John K. Eaton, Christopher J. Elkins, Tristan M. Burton
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Publication number: 20040004523Abstract: The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are: a method of assembling the hybrid magnetic plates, a high throughput protocol featuring the hybrid magnetic structure, and other embodiments of the ferromagnetic pole shape, attachment and adapter interfaces for adapting the use of the hybrid magnetic structure for use with liquid handling and other robots for use in high throughput processes.Type: ApplicationFiled: November 26, 2002Publication date: January 8, 2004Inventors: David E. Humphries, Martin J. Pollard, Christopher J. Elkin
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Publication number: 20030004564Abstract: A stent based drug delivery system. A biological agent of interest is entrapped within a matrix, which is loaded into channels on the surface of a stent. The matrix allows for release, usually sustained release, of the entrapped agent. The stent and matrix is sheathed with a covalently bound gel. In one embodiment of the invention, the stent is used to deliver therapeutic agents to a patient, providing the advantage of efficient delivery and sustained release of an agent at a localized site. In another embodiment of the invention, the drug delivery system is used for testing and comparison of candidate drugs in an in vivo setting.Type: ApplicationFiled: March 11, 2002Publication date: January 2, 2003Inventors: Christopher J. Elkins, Michael D. Dake, Jacob M. Waugh
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Publication number: 20020193336Abstract: Restenosis is inhibited through local delivery of anti-restenotic agents including angiotensin converting enzyme inhibitors; nicotine receptor agonists, agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors. In one embodiment of the invention, the localized delivery is effected through the use of a stent modified for delivery of the agent at the site of injury from balloon angioplasty.Type: ApplicationFiled: March 11, 2002Publication date: December 19, 2002Inventors: Christopher J. Elkins, Michael D. Dake, Jacob M. Waugh
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Patent number: RE41780Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: May 9, 2008Date of Patent: September 28, 2010Assignee: Lawrence Livermore National Security, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE43365Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: September 27, 2010Date of Patent: May 8, 2012Assignee: Lawrence Livermore National Security, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE45539Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: March 30, 2012Date of Patent: June 2, 2015Assignee: Lawrence Livermore National Security, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE46322Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: April 30, 2015Date of Patent: February 28, 2017Assignee: Lawrence Livermore National Security, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE47080Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: January 31, 2017Date of Patent: October 9, 2018Assignee: Lawrence Livermore National Security, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE48704Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: August 28, 2018Date of Patent: August 24, 2021Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin
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Patent number: RE48788Abstract: A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and detection of a sample comprising partitioning the sample into partitioned sections, performing PCR on the partitioned sections of the sample, and detecting and analyzing the partitioned sections of the sample.Type: GrantFiled: August 28, 2018Date of Patent: October 26, 2021Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Brian L. Anderson, Bill W. Colston, Christopher J. Elkin