Abstract: The present disclosure relates to a methods and systems for high speed laser surgery. In some implementations, the combination of mid-infrared (mid-IR) laser radiation with micro-scanning technology allows for large tissue ablation rates with minimal thermally affected zones, where micro-scanning distributes the heat generated by laser surgery over a large tissue area. Micro-scanning technology is compatible with hollow core fiber technology which can be implemented to deliver near diffraction limited mid-IR laser beams into the vicinity of the target area. Micro-scanning technology is compatible with hand tools for direct replacement of mechanical surgical tools such as scalpels as well as robotic surgery. Micro-scanning technology is also compatible with endoscopic beam delivery and can be combined with endoscopic tissue analysis. Tissue analysis can be performed with optical imaging technology as well as other analytical tools such as mass spectrometers.