Patents by Inventor Christopher J. Horvath
Christopher J. Horvath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150086546Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: December 3, 2014Publication date: March 26, 2015Inventors: Gregory J. Larosa, Christopher J. Horvath, Walter Newman, Stephan T. Jones, Siobhan H. O'Brien, Theresa L. O'Keefe
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Patent number: 8760449Abstract: A system includes a computing device that includes a memory for storing a three-dimensional model that represents particles of a coarse fire simulation. The computing device also includes a graphics refiner for producing two-dimensional simulation segments from the three-dimensional model that represents particles of a coarse fire simulation. The separation distance between two or more of the two-dimensional simulation segments is based upon a level of spatial detail provided by the coarse fire simulation. The graphics refiner is configured to separately process the two-dimensional simulation segments to produce a detailed fire simulation.Type: GrantFiled: October 15, 2012Date of Patent: June 24, 2014Assignee: Lucasfilm Entertainment Company, Ltd.Inventor: Christopher J. Horvath
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Publication number: 20130071381Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: June 20, 2012Publication date: March 21, 2013Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Patent number: 7566450Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: GrantFiled: October 26, 2007Date of Patent: July 28, 2009Assignee: Millennium Pharmaceuticals, Inc.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20090169541Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 26, 2007Publication date: July 2, 2009Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20090142339Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 26, 2007Publication date: June 4, 2009Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20080268536Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 25, 2007Publication date: October 30, 2008Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20080241136Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 26, 2007Publication date: October 2, 2008Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20080241923Abstract: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.Type: ApplicationFiled: October 25, 2007Publication date: October 2, 2008Applicant: MILLENNIUM PHARMACEUTICALS, INC.Inventors: Gregory J. LaRosa, Christopher J. Horvath, Walter Newman, S. Tarran Jones, Siobhan H. O'Brien, Theresa O'Keefe
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Publication number: 20040101527Abstract: The invention is based on the discovery that molecules (e.g. a monoclonal antibody or a portion thereof) which bind specifically with the CD18 subunit of a CD18-containing leukocyte cell-surface antigens (e.g. a cell-surface antigen such as Mac-1 which contains both CD18 and a form of CD11) can be used to inhibit, prevent, and alleviate vascular stenotic and restenotic lesions and symptoms and disorders associated with such lesions.Type: ApplicationFiled: November 17, 2003Publication date: May 27, 2004Applicant: Millennium Pharmaceuticals, Inc., a Delaware corporationInventor: Christopher J. Horvath
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Patent number: 6663863Abstract: The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.Type: GrantFiled: March 15, 2001Date of Patent: December 16, 2003Assignee: Millennium Pharmaceuticals, Inc.Inventors: Christopher J. Horvath, Patricia E. Rao
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Publication number: 20020106369Abstract: The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD 18 or CCR2.Type: ApplicationFiled: March 15, 2001Publication date: August 8, 2002Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher J. Horvath, Patricia E. Rao