Patents by Inventor CHRISTOPHER J SCHOFIELD

CHRISTOPHER J SCHOFIELD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOPENICILLIN N SYNTHETASE AND DEACETOXYCEPHALOSPORIN C SYNTHETASE ENZYMES AND METHODS
    Publication number: 20030088058
    Abstract: A three-dimensional structure is described of a complex of isopenicillin N synthase (IPNS) with Fe and its substrate ACV. This structure is used to design modified enzymes IPNS, DAOCS, DACS, DAOC/DACS and other related enzymes of the penicillin and cephalosporin biosynthesis pathway, which modified enzymes may accept unnatural substrates or improve production efficiency or produce improved products. Specific modifications of specific amino acid residues are proposed and exemplified.
    Type: Application
    Filed: May 19, 1999
    Publication date: May 8, 2003
    Inventors: CHRISTOPHER J SCHOFIELD, JACK E BALDWIN, IAN CLIFTON, JANOS HAJDU, CHARLES M. H. HENSGENS, PETER L ROACH