Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: A system that receives plurality of data that includes dimensions (e.g., revenue, profit margin, level of effort, urgency or alignment to the organization's technology strategy) and criteria (e.g., business unit, product, or service) that are relevant to drive an organization's priorities. The system generates a visual display on which a representation (e.g., a sphere, circle, square, or other shape) for each of the projects is depicted. In various embodiments, the user may select one dimension to be used as an x-axis scale of the visual display and a second dimension to be used as a y-axis scale of the visual display. The system plots a representation for each project against various dimensions that are meaningful to the business organization.

Abstract: Decision software implements a decision process that handles and decides a request from a requestor in a generally automated manner. The decision software denies the request according to a predefined standard. Information relating to the request and the denial decision is stored as a quote, and it is determined that further consideration of the denial decision by a human reviewer of the organization is desired. The human reviewer is contacted and retrieves the stored quote by way of an actuated interface that presents the quote as a focused screen including information from the quote and a determination entry device. The human interviewer determines based at least in part on the focused screen whether to over-ride the denial decision and enters such determination into the determination entry device. The entered determination is stored with the stored quote and the request proceeds in accordance with the stored determination.