Abstract: Provided herein are analytical methods utilizing a self-limiting catalytic reaction, and compositions and kits useful therefore. In one aspect the method is used to quantify Pd, and in another, the method is a horseradish peroxidase assay.

Abstract: Provided herein are analytical methods utilizing a self-limiting catalytic reaction, and compositions and kits useful therefore. In one aspect the method is used to quantify Pd, and in another, the method is a horseradish peroxidase assay.

Abstract: The present invention relates to methods for generating limited chemical diversity for biologically relevant lead molecules by late state functionalization, separation, and post-functionalization modification. The methods optionally include one or more screening steps. Traditional drug development has relied on the synthesis of individual compounds or the generation of large chemical libraries, but these methods have generally been fairly inefficient in obtaining drug products.

Abstract: The invention discloses a novel process for the preparation of enantiomerically enriched mixtures of compounds of structural formula I which are useful intermediates in the synthesis of &agr;v&bgr;3 integrin receptor antagonists

Abstract: The invention discloses a novel process for the preparation of enantiomerically enriched mixtures of compounds of structural formula I which are useful intermediates in the synthesis of &agr;v&bgr;3 integrin receptor antagonists.

Abstract: The invention discloses a method for rapid identification of a candidate selective separation material by placing small samples of the candidate material in an array of vials and adding a solution of the analytes to be separated. The solution is allowed to interact or equilibrate and the distribution of the analytes in the solid or liquid phase is measured usually by gas or liquid chromatography. The identified candidate material with the greatest differential adsorption of the analytes is selected and used as an adsorbent for large scale separation. The rapid screening of chromatographic adsorbents provides an efficient way of finding suitable absorbent materials for large scale separations.

Abstract: The invention discloses a method for rapid identification of a candidate selective separation material by placing small samples of the candidate material in an array of vials and adding a solution of the analytes to be separated. The solution is allowed to interact or equilibrate and the distribution of the analytes in the solid or liquid phase is measured usually by gas or liquid chromatography. The identified candidate material with the greatest differential adsorption of the analytes is selected and used as an adsorbent for large scale separation. The rapid screening of chromatographic adsorbents provides an efficient way of finding suitable absorbent materials for large scale separations.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsteroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: Carbon clusters, such as C.sub.60 and C.sub.70 fullerenes are separated by means of a recognition selector having the formula: ##STR1## wherein R.sub.1 is ##STR2## wherein R.sub.2 is O, S or NR.sub.12 wherein R.sub.12 is independently hydrogen or P.dbd.O with the proviso that when R.sub.12 is P.dbd.O, then only one such group is present and all R.sub.2 's are additionally bonded to R.sub.12,R.sub.4 is independently O, S or NH,R.sub.3 and R.sub.5 are each independently hydrogen or lower alkyl,n and o are each independently zero, 1, 2 or 3,p, q, r, s and t are each independently zero or 1,Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 carbon atoms, either of which may be unsubstituted or substituted with one or more lower alkyl, NO.sub.2, N(R.sub.6).sub.3.sup.30, CN COOR.sub.7, SO.sub.3 H, COR.sub.8 and OR.sub.9 wherein R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are each independently hydrogen or lower alkyl;W is H or CH.dbd.CH.sub.2 ; andm is 1 to 10.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsterodial anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: A high performance chiral selector having the formula: ##STR1## wherein Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, NO.sub.2, N(R.sub.5).sub.3.sup.+, CN, COOR.sub.6 SO.sub.3 H and COR.sub.7 groups wherein R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 to C.sub.6 alkyl or phenyl;R.sub.3 and R.sub.4 are each independently C.sub.1 to C.sub.12 alkyl or C.sub.2 to C.sub.12 alkenyl; andm and n are each independently zero or 1, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsterodial anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: Carbon clusters, such as C.sub.60 and C.sub.70 fullerenes are separated by means of a recognition selector having the formula: ##STR1## wherein R.sub.1 is ##STR2## wherein R.sub.2 is O, S or NR.sub.12 wherein R.sub.12 is independently hydrogen or P.dbd.O with the proviso that when R.sub.12 is P.dbd.O, then only one such group is present and all R.sub.2 's are additionally bonded to R.sub.12,R.sub.4 is independently O, S or NH,R.sub.3 and R.sub.5 are each independently hydrogen or lower alkyl,n and o are each independently zero, 1, 2 or 3,p, q, r, s and t are each independently zero or 1,Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 carbon atoms, either of which may be unsubstituted or substituted with one or more lower alkyl, NO.sub.2, N(R.sub.6).sub.3.sup.+, CN, COOR.sub.7, SO.sub.3 H, COR.sub.8 and OR.sub.9 wherein R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are each independently hydrogen or lower alkyl;W is H or CH.dbd.CH.sub.2 ; andm is 1 to 10.

Abstract: A high performance chiral selector having the formula: ##STR1## wherein Ar is a monocyclic or ortho-fused polycyclic aromatic moiety having up to 10 ring carbon atoms, either of which may be unsubstituted or substituted with one or more C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, NO.sub.2, N(R.sub.5).sub.3.sup.+, CN, COOR.sub.6, SO.sub.3 H and COR.sub.7 groups wherein R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.1 and R.sub.2 ar each independently hydrogen, C.sub.1 to C.sub.6 alkyl or phenyl;R.sub.3 and R.sub.4 are each independently C.sub.1 to C.sub.12 alkyl or C.sub.2 to C.sub.12 alkenyl; andm and n are each independently zero or 1, said compound being an R or an S enantiomer or a mixture of R and S enantiomers.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsterodial anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first linking group at least three angstroms long. The first conjugate and the bound cobalamins in the sample are then exposed to a second conjugate of a cobalamin linked to a detectable enzyme to produce second conjugate bound to first conjugate and unbound second conjugate. The enzyme activity associated either with the solid phase first conjugate or the unbound second conjugate is then detected. By linking affinity purified intrinsic factor to a latex or latex-like solid phase with a first linking group at least three angstroms long, an exzyme assay can be performed which detects levels of cobalamins in patient samples within or below normal ranges found in such samples.

Abstract: Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e.g. antibodies to enzymes) for use in diagnostic assays.

Abstract: Novel methods for covalent attachment of antibodies, antigens, or other molecules to solid phases using extended length heterobifunctional crosslinking reagents are disclosed. The resulting derivatized solid phases can be used in diagnostic assays.

Abstract: Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e.g. antibodies to enzymes) for use in diagnostic assays.