Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

Abstract: System, methods, and other embodiments described herein relate to sensing interactions of a passenger with components within a vehicle. In one embodiment, a method includes acquiring, from a radar of a vehicle, radar data about a passenger cabin of the vehicle. The method includes determining a current state of the passenger cabin according to the radar data. The method includes, responsive to identifying that the current state indicates that a passenger satisfies a threshold in relation to an unpermitted action, generating a response that counters the unpermitted action.

Abstract: Methods of classifying flow cytometer data are provided. Methods of interest include receiving a first gate and flow cytometer data, expanding the first gate to generate a second gate, and determining sets of flow cytometer data encompassed by each of the first gate and the second gate to classify the flow cytometer data. In embodiments, methods also involve recording a subset of the classified flow cytometer data and optionally adjusting the first and/or second gates based on the recorded data. In some cases, the subject methods include sorting particles associated with the classified flow cytometer data based on the first and second gates. Systems and computer-readable storage media for practicing the invention are also provided.

Abstract: The present technology is directed to adjustable flow glaucoma shunts, systems, and methods for making and using such devices. In many of the embodiments described herein, the shunts include a drainage element configured to fluidly couple an anterior chamber of an eye and a target outflow location, such as a subconjunctival bleb space. The shunts can further include a flow control assembly coupled to the drainage element and configured to control the flow of fluid (e.g., aqueous) therethrough. The shunts can further include an outer membrane or bladder that encases the flow control assembly. The outer membrane can include a plurality of apertures that fluidly couple an interior of the outer membrane with an environment exterior to the outer membrane.

Abstract: Techniques for a virtualized fabric login server for a storage area network are described herein. An aspect includes operating a storage area network, the storage area network including a hybrid control plane. Another aspect includes managing, using a virtualized fabric login server and the hybrid control plane, the storage area network, wherein the virtualized fabric login server is disposed in a container that is hosted on an element of the storage area network.

Abstract: A process for management of Internet-of-Things (IoT) devices includes a management system for identifying, interrogating, and updating devices connected to one or more networks. The management system can include a data store for storing various data related to the devices and the various processes of the management system. The management system can include a controller for executing processes such as interrogation processes, firmware change processes, credential change processes, and other processes. The controller can determine versions of firmware and other configuration properties of a device and generate various profiles for updating the firmware and other configuration properties. The controller can determine upgrade paths for updating the firmware and other configuration properties from a first version to a second version, the upgrade paths including one or more intermediary versions for facilitating the upgrade path.

Abstract: A device for measuring oxygen saturation includes circuitry configured to determine a measured difference of forward voltage based on a first forward voltage at a first light emitting diode and a second forward voltage a second light emitting diode and determine that the first and second light emitting diodes are valid based on a calibrated difference of forward voltage and the measured difference of forward voltage. In response to the determination that the first and second light emitting diodes are valid, the circuitry is configured to determine an oxygen saturation level.

Abstract: The present technology is directed to adjustable flow glaucoma shunts and methods for making and using such devices. In many of the embodiments described herein, the shunts include a generally flat frame. The frame can include an elongated portion having a lumen extending therethrough and a bladder portion defining an interior chamber that is in fluid communication with the lumen. When implanted in a patient's eye, aqueous can drain from the anterior chamber to a target outflow location via the lumen and interior chamber. In some embodiments, the shunts include a flow control assembly positioned within the interior chamber of the bladder portion to control the flow of aqueous through the lumen.

Abstract: A device for measuring oxygen saturation includes circuitry configured to determine a series resistance for a light emitting diode based on a first diode voltage at the light emitting diode for a first current, a second diode voltage at the light emitting diode for a second current, and a third diode voltage at the light emitting diode for a third current. The circuitry is further configured to determine an intensity of a received photonic signal corresponding to an output photonic signal output using the light emitting diode. The circuitry is further configured to determine an oxygen saturation level based on the intensity of the received photonic signal and the series resistance.

Abstract: A vehicle tailgate (30) has a frame (40) with a cross beam (42) and a pair of side beams (44, 46). One side beam (44, 46) extends from each end of the cross beam (42). A first metal tapping plate (50, 150) is secured with the cross beam (42). At least one elongated tang (56) is positioned between the body (52) and each tab (54). A clevis bracket (82) is positioned on the side beams (44, 46). An overmolded (108) material is on the shaft (100, 102) and the two heads (96, 98) of the striker (88). The wedges (92, 94), on the clevis bracket (82), aligns the clevis bracket (82) with the striker (84). A second tapping plate (70) is secured to the sheet metal.

Abstract: A delivery apparatus includes a steerable shaft having a pull-wire conduit. A pull wire extends through the pull-wire conduit. The steerable shaft includes one or more layers. A compression-resistance portion is incorporated into at least one of the one or more layers. A cross-section of the compression-resistance portion has an arcuate shape that extends along a portion of a cross-section of the steerable shaft. The compression-resistance portion has a hardness that is greater than a hardness of the one or more layers that the compression-resistance portion is incorporated into.

Abstract: The present disclosure teaches a solution for a user customizable abstraction layer for tailoring all operating system, application, and web based interfaces. The interface differs from conventional user interfaces by presenting a dynamic interface which can enable user access across all domains and applications with which the user can interact. The interface can be dynamically built as a user interacts with clients (e.g., devices/applications). Clients can utilize common usage patterns, installed application, installed themes, personal information, and the like, to create a highly customized adaptive user designed and modifiable interface.

Abstract: Disclosed herein are transistor electrode-channel arrangements, and related methods and devices. For example, in some embodiments, a transistor electrode-channel arrangement may include a channel material, source/drain electrodes provided over the channel material, and a sealant at least partially enclosing one or more of the source/drain electrodes, wherein the sealant includes one or more metallic conductive materials.

Abstract: A building management system includes building equipment operable to affect a variable state or condition of a building and a controller including a processing circuit. The processing circuit is configured to obtain a vibration data set related to vibrations of the building equipment and analyze the vibration data set by one or more machine learning models to generate a set of probabilities. The set of probabilities is related to a probability that the vibration data set is abnormal. The processing circuit is configured to identify the vibration data set as normal or abnormal based on the set of probabilities and initiate a corrective action responsive to identifying the vibration data set as abnormal.

Abstract: A method including receiving a request associated with one or more map views associated with a map, transmitting a first set of one or more map views, generating a display of at least one of the first set of one or more map views, receiving a user input associated with the display of the at least one of the first set of one or more map views, and receiving a message associated with the user input. The method may include deter mining a mapping context function based on the received message, the mapping context function being based on one or more user actions associated with one or more features on at least one previously accessed map, determining whether to modify a second set of one or more map views based on the mapping context function, and transmitting the second set of one or more map views.

Abstract: Wireless chargers that can properly align and securely hold an electronic device, provide power to more than one electronic device, and fold into a compact shape. One example can provide a wireless charger having an alignment feature to align an electronic device to the wireless charger. The wireless charger can include a first leaf having first charging components for charging a first electronic device and a second leaf having a charging puck that includes second charging components for charging a second electronic device. The charging puck can move between a down position and an up position. The charging puck can be moved away from the second leaf while in the up position. The charging puck can retract when moved to the down position. The first leaf and the second leaf can fold together into a compact shape.

Abstract: Methods and systems are described for providing end-to-end beamforming. For example, end-to-end beamforming systems include end-to-end relays and ground networks to provide communications to user terminals located in user beam coverage areas. The ground segment can include geographically distributed access nodes and a central processing system. Return uplink signals, transmitted from the user terminals, have multipath induced by a plurality of receive/transmit signal paths in the end to end relay and are relayed to the ground network. The ground network, using beamformers, recovers user data streams transmitted by the user terminals from return downlink signals. The ground network, using beamformers generates forward uplink signals from appropriately weighted combinations of user data streams that, after relay by the end-end-end relay, produce forward downlink signals that combine to form user beams.

Abstract: An embodiment comprises methods of managing and systems for processing media projects. The project processing system comprises a memory circuit and a hardware processor configured to execute computer-executable instructions. The hardware processor executes the computer-executable instructions to identify a first dynamic structure associated with a first media project and determine that a first user is permitted to view and modify details regarding the first media project on the first dynamic structure. The hardware processor also executes the computer-executable instructions to create a first data block representing a first transaction by which the first user agrees to contribute at least one service, good, or fund to the first media project and broadcast the first data block to a distributed network for validation of one or more aspects of the first transaction.

Abstract: The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The present invention also relates to nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example, nucleic acids encoding antibodies that are amplified from a B-cell using the methods of the invention maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.