Abstract: The invention comprises a method and apparatus for processing a material in a supercritical fluid, comprising the steps of: providing a supercritical fluid system comprising the supercritical fluid in a supercritical fluid container; breaking down the material in the supercritical fluid to form gases, the gases comprising at least carbon dioxide; transferring at least a portion of the gases out of the supercritical fluid system; and capturing at least a portion of the carbon dioxide in a carbon capture system in the process of transferring, where the system is optionally and preferably additionally used to produce, from waste material, carbon monoxide and molecular hydrogen that is input into a Fischer-Tropsch system for use in the generation of fuel.

Abstract: The invention comprises a method for controlling feedstock feedback, comprising the steps of: (1) breaking down a waste product feedstock in a supercritical fluid chamber; (2) transferring at least carbon monoxide and molecular hydrogen from the supercritical fluid chamber into a Fischer-Tropsch system; (3) generating a byproduct in the Fischer-Tropsch system, the byproduct comprising a hydrocarbon chain of less than eight carbons; and (4) feeding the hydrocarbon chain back into the supercritical fluid chamber via a feedstock feedback system, where the feedstock is optionally and preferably municipal solid waste, plastic, and/or rubber.

Abstract: The invention comprises a method for monitoring a material processed with a supercritical fluid, comprising the steps of: generating a control signal from photons passed through at least a portion of the material; processing the material in the supercritical fluid inside a supercritical fluid chamber, the supercritical fluid chamber pressurized to a pressure of greater than thirteen bar; and controlling the step of processing with a controller and the control signal, with optional steps any of: determining a termination time of the step of processing with the control signal; controlling movement of a mechanical system, subsequent to the step of determining the termination time, to move the material out of the supercritical fluid chamber; and injecting molecular hydrogen from the supercritical fluid chamber into a Fischer-Tropsch system.

Abstract: The invention comprises a method for processing waste material with a supercritical fluid to produce a Fischer-Tropsch process input, comprising the steps of breaking down the waste material in the supercritical fluid in a supercritical fluid chamber and incorporating at least supercritical water in the supercritical fluid, optionally including any of the steps of: maintaining a pressure of greater than two hundred seventeen bar in the supercritical fluid chamber; monitoring at least one breakdown process of the waste material with light from a spectrometer; transferring into an input chamber of the Fischer-Tropsch process an auxiliary hydrogen gas from a non-supercritical fluid source; feeding back into the supercritical fluid chamber at least one byproduct generated in the Fischer-Tropsch system; and generating a fuel, in the Fischer-Tropsch system incorporating the Fischer-Tropsch process, with at least a twelve carbon aliphatic.

Abstract: The invention comprises a method for controlling reactions in a supercritical fluid chamber, comprising the steps of: forming a formed hydrogen gas in a supercritical fluid chamber; outputting the formed hydrogen gas from the supercritical fluid chamber; feeding a first portion of the formed hydrogen gas back into the supercritical fluid chamber through a feedstock feedback system; measuring quantity of the first portion of the hydrogen gas in the feedback system with a sensor; and controlling flow of the first portion of the hydrogen gas back into the supercritical fluid chamber with a controller and output from the sensor, where a majority of the formed hydrogen gas is formed in the breakdown as waste products, such as waste plastic and/or waste rubber. Optionally, a second portion of the formed hydrogen gas is used in a Fischer-Tropsch process in fuel generation.

Abstract: The invention comprises an apparatus and method of use thereof for processing a waste product feedstock, comprising the steps of: converting the waste product feedstock, in a supercritical fluid chamber, into at least: water, carbon monoxide, and molecular hydrogen; moving the water, in a supercritical fluid system output system, from the supercritical fluid chamber to an electrolysis system; maintaining a temperature of the water at greater than one hundred degrees Fahrenheit from a first time of exiting the supercritical fluid chamber to a second time of entering the electrolysis system; and electrochemically converting the water into at least a generated hydrogen gas in the electrolysis system with optional steps of feeding at least a portion of the carbon monoxide and the molecular hydrogen into a Fischer-Tropsch system and generating fuel with the Fischer-Tropsch system.

Abstract: The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.

Abstract: The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.

Abstract: A customer gains access to cloud networking resources through a customer device, such as a router providing a point of presence (POP) to the network. Due to limitations of remote equipment such as routers, complete routing information for data packets may not be available from the origin due to the dynamic nature of the network and security requirements. Proxy machines are placed at the network edge that serve as a proxy for routing network data packets to the virtual network Placing proxy machines at the network edge requires space, power and maintenance of the programmable processing machines serving as proxies. Techniques for bypassing proxy machines to reduce network congestion and latency are described. Data packets are selected to bypass proxies when additional routing information is not needed for the packet. Proxy machines may be implemented as virtual machines within a data center hosting the virtual network.

Abstract: Disclosed herein are methods of reducing or preventing cerebral edema in a subject after a stroke by administering systemically a therapeutically effective amount of a PD-1 agonist to the subject. Also disclosed herein are methods of treating neuroinflammation, improving gait, improving sensorimotor deficits, reducing the number of PD-1 positive monocytes in the brain, decreasing intracranial pressure, shifting the phenotype of monocytes in the brain from a classical inflammatory subtype to a non-classical subtype, and limiting or reducing secondary inflammatory injury, reducing a risk of a second or more stroke events in a subject after a stroke.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: A computer having a system for mitigating mechanical rattle arising due to a mechanical coupling of an audio output transducer to a part of the computer device, the system comprising: a processing subsystem configured to receive an input audio signal and to output a drive signal for driving the audio output transducer to produce a transducer output, wherein the processing subsystem is configured to selectively apply an attenuation function to the input audio signal to attenuate a signal component of the input audio signal at a frequency that causes mechanical rattle in the computer; and an analyser subsystem configured to receive the input audio signal and to output a control signal to the processing subsystem to control application of the attenuation function to the input audio signal by the processing subsystem based on a spectral content of the received input audio signal; wherein the attenuation function is based on characteristic acoustic behaviour of the computer.

Abstract: Described herein are microorganisms, in particular yeast, which have been transformed with one or more expression construct(s) for i) the overexpression of the native genes encoding xylulose kinase (XKS1), transaldolase (TAL1), transketolase 1 (TKL1) and transketolase 2 (TKL2) and ii) the expression of a functional heterologous gene encoding a xylose isomerase (XI), where the xylose isomerase (XI) gene is derived from a microorganism selected from the group consisting of T. neapolitana, A. andensis and C. clariflavum. Also described herein are expression constructs, methods for fermenting pentose sugars using the microorganisms and methods for producing such microorganisms.

Abstract: A system has a memory programmed with multiple firmware images each having an associated distinct entry point, a processor, a writable hardware register, and a controller external to the processor that, prior to each reset of a sequence of resets of the processor, reads the entry point of a firmware image from the hardware register and causes the processor to begin fetching instructions at the entry point read from the hardware register. The firmware images include boot, mission mode, and at least one other firmware image. The memory may be writeable with a modifiable version of a post-production mission mode, debug, prototype, or patched ROM firmware image. A second controller writes a second entry point to the hardware register prior to an initial reset such that the external controller reads the second entry point and causes fetching instructions at the second entry point rather than the initial entry point.

Abstract: A distributed processing system with multiple systems connected by an inter-system communication interface. Each system has a memory programmed with multiple firmware images each having a distinct entry point, a processor, a writable (by another system of the distributed processing system) hardware register initially seeded with an initial firmware image entry point, and a controller external to the processor that, prior to an initial reset, reads the entry point from the hardware register and causes the processor to begin fetching instructions at the initial entry point. Prior to a subsequent reset of the processor, the external controller facilitates a transition to another firmware image by reading its entry point from the hardware register and causing the processor to begin fetching instructions at the other entry point. Each system may have multiple processors and multiple associated hardware registers writeable by another processor of the system or a by host processor.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods utilizing Meteorin-like (METRNL), C-X-C Motif Chemokine Receptor 6 (CXCR6) and/or endogenous C-X-C Motif Ligand 16 (CXCL16) as immune-oncology targets. Accordingly, in one aspect, the present invention provides compositions and methods directed to the knockout of METRNL, CXCR6 and/or CXCL16 expression in a cell. In particular embodiments, the cell is a T cell. In a specific embodiment, the present invention provides an engineered T-cell comprising disruption in the METRNL, CXCR6 and/or CXCL16 gene sequence. In another embodiment, an engineered T-cell comprises (a) at least one chimeric antigen receptor (CAR); and (b) at least one genomic disruption of METRNL, CXCR6 and/or CXCL16. In certain embodiments, the genomic disruption is performed using a CRSIPR endonuclease system.

Abstract: Methods and compositions for treating a glioblastoma (GBM) by administering a composition comprising a hydrogel and an anti-programmed cell death protein 1 (PD-1) antibody to one or more draining lymph nodes (DLNs) of a subject in need of treatment thereof are disclosed.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: A distributed processing system with multiple systems connected by an inter-system communication interface. Each system has a memory programmed with multiple firmware images each having a distinct entry point, a processor, a writable (by another system of the distributed processing system) hardware register initially seeded with an initial firmware image entry point, and a controller external to the processor that, prior to an initial reset, reads the entry point from the hardware register and causes the processor to begin fetching instructions at the initial entry point. Prior to a subsequent reset of the processor, the external controller facilitates a transition to another firmware image by reading its entry point from the hardware register and causing the processor to begin fetching instructions at the other entry point. Each system may have multiple processors and multiple associated hardware registers writeable by another processor of the system or a by host processor.