Abstract: The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.

Abstract: A customer gains access to cloud networking resources through a customer device, such as a router providing a point of presence (POP) to the network. Due to limitations of remote equipment such as routers, complete routing information for data packets may not be available from the origin due to the dynamic nature of the network and security requirements. Proxy machines are placed at the network edge that serve as a proxy for routing network data packets to the virtual network Placing proxy machines at the network edge requires space, power and maintenance of the programmable processing machines serving as proxies. Techniques for bypassing proxy machines to reduce network congestion and latency are described. Data packets are selected to bypass proxies when additional routing information is not needed for the packet. Proxy machines may be implemented as virtual machines within a data center hosting the virtual network.

Abstract: Disclosed herein are methods of reducing or preventing cerebral edema in a subject after a stroke by administering systemically a therapeutically effective amount of a PD-1 agonist to the subject. Also disclosed herein are methods of treating neuroinflammation, improving gait, improving sensorimotor deficits, reducing the number of PD-1 positive monocytes in the brain, decreasing intracranial pressure, shifting the phenotype of monocytes in the brain from a classical inflammatory subtype to a non-classical subtype, and limiting or reducing secondary inflammatory injury, reducing a risk of a second or more stroke events in a subject after a stroke.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: A computer having a system for mitigating mechanical rattle arising due to a mechanical coupling of an audio output transducer to a part of the computer device, the system comprising: a processing subsystem configured to receive an input audio signal and to output a drive signal for driving the audio output transducer to produce a transducer output, wherein the processing subsystem is configured to selectively apply an attenuation function to the input audio signal to attenuate a signal component of the input audio signal at a frequency that causes mechanical rattle in the computer; and an analyser subsystem configured to receive the input audio signal and to output a control signal to the processing subsystem to control application of the attenuation function to the input audio signal by the processing subsystem based on a spectral content of the received input audio signal; wherein the attenuation function is based on characteristic acoustic behaviour of the computer.

Abstract: Described herein are microorganisms, in particular yeast, which have been transformed with one or more expression construct(s) for i) the overexpression of the native genes encoding xylulose kinase (XKS1), transaldolase (TAL1), transketolase 1 (TKL1) and transketolase 2 (TKL2) and ii) the expression of a functional heterologous gene encoding a xylose isomerase (XI), where the xylose isomerase (XI) gene is derived from a microorganism selected from the group consisting of T. neapolitana, A. andensis and C. clariflavum. Also described herein are expression constructs, methods for fermenting pentose sugars using the microorganisms and methods for producing such microorganisms.

Abstract: A system has a memory programmed with multiple firmware images each having an associated distinct entry point, a processor, a writable hardware register, and a controller external to the processor that, prior to each reset of a sequence of resets of the processor, reads the entry point of a firmware image from the hardware register and causes the processor to begin fetching instructions at the entry point read from the hardware register. The firmware images include boot, mission mode, and at least one other firmware image. The memory may be writeable with a modifiable version of a post-production mission mode, debug, prototype, or patched ROM firmware image. A second controller writes a second entry point to the hardware register prior to an initial reset such that the external controller reads the second entry point and causes fetching instructions at the second entry point rather than the initial entry point.

Abstract: A distributed processing system with multiple systems connected by an inter-system communication interface. Each system has a memory programmed with multiple firmware images each having a distinct entry point, a processor, a writable (by another system of the distributed processing system) hardware register initially seeded with an initial firmware image entry point, and a controller external to the processor that, prior to an initial reset, reads the entry point from the hardware register and causes the processor to begin fetching instructions at the initial entry point. Prior to a subsequent reset of the processor, the external controller facilitates a transition to another firmware image by reading its entry point from the hardware register and causing the processor to begin fetching instructions at the other entry point. Each system may have multiple processors and multiple associated hardware registers writeable by another processor of the system or a by host processor.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods utilizing Meteorin-like (METRNL), C-X-C Motif Chemokine Receptor 6 (CXCR6) and/or endogenous C-X-C Motif Ligand 16 (CXCL16) as immune-oncology targets. Accordingly, in one aspect, the present invention provides compositions and methods directed to the knockout of METRNL, CXCR6 and/or CXCL16 expression in a cell. In particular embodiments, the cell is a T cell. In a specific embodiment, the present invention provides an engineered T-cell comprising disruption in the METRNL, CXCR6 and/or CXCL16 gene sequence. In another embodiment, an engineered T-cell comprises (a) at least one chimeric antigen receptor (CAR); and (b) at least one genomic disruption of METRNL, CXCR6 and/or CXCL16. In certain embodiments, the genomic disruption is performed using a CRSIPR endonuclease system.

Abstract: Methods and compositions for treating a glioblastoma (GBM) by administering a composition comprising a hydrogel and an anti-programmed cell death protein 1 (PD-1) antibody to one or more draining lymph nodes (DLNs) of a subject in need of treatment thereof are disclosed.

Abstract: Systems and methods to provide remote support services to a testing device are disclosed. An example testing device includes a computing device configured to obtain a measurement value related to the material or component under test. The computing device includes: a display; an input device; a processor; and a memory coupled to the processor and storing computer readable instructions which, when executed by the processor, cause the processor to: in response to first input via the input device, transmit a request for a technical support service to a remote computing system; perform, at the computing device, one or more remote service actions associated with the technical support service.

Abstract: A distributed processing system with multiple systems connected by an inter-system communication interface. Each system has a memory programmed with multiple firmware images each having a distinct entry point, a processor, a writable (by another system of the distributed processing system) hardware register initially seeded with an initial firmware image entry point, and a controller external to the processor that, prior to an initial reset, reads the entry point from the hardware register and causes the processor to begin fetching instructions at the initial entry point. Prior to a subsequent reset of the processor, the external controller facilitates a transition to another firmware image by reading its entry point from the hardware register and causing the processor to begin fetching instructions at the other entry point. Each system may have multiple processors and multiple associated hardware registers writeable by another processor of the system or a by host processor.

Abstract: A system has a memory programmed with multiple firmware images each having an associated distinct entry point, a processor, a writable hardware register, and a controller external to the processor that, prior to each reset of a sequence of resets of the processor, reads the entry point of a firmware image from the hardware register and causes the processor to begin fetching instructions at the entry point read from the hardware register. The firmware images include boot, mission mode, and at least one other firmware image. The memory may be writeable with a modifiable version of a post-production mission mode, debug, prototype, or patched ROM firmware image. A second controller writes a second entry point to the hardware register prior to an initial reset such that the external controller reads the second entry point and causes fetching instructions at the second entry point rather than the initial entry point.

Abstract: A computer-implemented method for configuring data deduplication is disclosed. The computer-implemented method includes receiving source data. The computer-implemented method further includes analyzing the source data, wherein analyzing the source data includes generating data profiling statistics from the source data and classifying attributes of the source data. The computer-implemented method further includes determining at least one data domain associated with the source data based, at least in part, on the data profiling statistics, the classified attributes, and ontology data. The computer-implemented method further includes determining, for the at least one data domain associated with the source data, a number of required matching algorithms for a data matching engine to execute data deduplication within the source data.

Abstract: The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.

Abstract: A respiratory filter and condensate management apparatus is provided for use in a breathing circuit during patient respiration. The apparatus includes a housing having an air inlet port for receiving a flow of respiratory air, and an air outlet port for outputting the flow of respiratory air to a ventilator. A filter compartment is provided within the housing and includes a filter member located in a flow path of the respiratory air from the air inlet port to the air outlet port. A condensate collection compartment is provided within the housing and includes at least one reservoir and at least one self-sealing drainage port. The reservoir collects liquid formed by condensation of the respiratory air within the filter compartment, and the drainage port allows removal of the collected liquid from the reservoir while the housing remains connected to the breathing circuit.

Abstract: One embodiment includes a computing device including peripheral component bus interfaces for connection to a peripheral component bus, a first integrated circuit (IC) chip comprising a processor to initiate a register setup process of the device, a second IC chip including a tile processor including multiple tiles, each tile including at least a processing core configured to generate requests to at least one of the peripheral component bus interfaces, steering configuration registers to store steering configuration data, and steering logic to steer the generated requests responsively to the steering configuration data in the steering configuration registers, and steering register setup circuitry including a multicaster and a register setup memory, wherein the processor is configured to write the steering configuration data to the register setup memory, and the multicaster is configured to multicast the steering configuration data written to the register setup memory to the steering configuration registers of

Abstract: Described herein are microorganisms, in particular yeast, which have been transformed with one or more expression construct(s) for i) the overexpression of the native genes encoding xylulose kinase (XKS1), transaldolase (TAL1), transketolase 1 (TKL1) and transketolase 2 (TKL2) and ii) the expression of a functional heterologous gene encoding a xylose isomerase (XI), where the xylose isomerase (XI) gene is derived from a microorganism selected from the group consisting of T. neapolitana, A. andensis and C. clariflavum. Also described herein are expression constructs, methods for fermenting pentose sugars using the microorganisms and methods for producing such microorganisms.

Abstract: Methods and apparatus to control staging of test specimens. Disclosed example systems to perform automated testing include: a stage configured to secure one or more test specimens; one or more actuators configured to position the stage and the one or more test specimens; a user interface configured to: receive input defining a test sequence of a plurality of points to be tested on the one or more test specimens; display a graphic indicative of positions of the plurality of points on the one or more test specimens and one or more paths to be taken by the stage to traverse the plurality of points during testing of the test sequence; and control circuitry configured to control a test process of the test sequence in accordance with the plurality of points and the one or more paths.