Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: A method includes identifying records in a database for labeling; presenting one of the records in the database to a first labeling entity; and receiving a first observation on an information source in the one of the records from the first labeling entity. The first observation has one of a plurality of observation types associated therewith. The plurality of observation types including a validation observation type in which the first observation comprises a confirmation of whether a second observation on the information source in the one of the records from another labeling entity is accurate and an edit for the second observation when the second observation is confirmed as inaccurate. The one of the records is updated in the database with the first observation on the information source in the one of the records from the first labeling entity.

Abstract: Determining proportionate use of system resources by applications executing in a shared hosting environment, including executing monitor agents, one monitor agent for one or more instances of the applications, including collecting by the monitor agents data describing each instance of use of a system resource by an instance of the applications; storing by the monitor agents the collected data in data records, each data record representing a use of the system resources by a using instance of an application, the using instance comprising an instance of an application that uses a resource as represented by a data record; and storing by the monitor agents in the data records monitor tags, the monitor tags identifying each data record and identifying each using instance of an application for each data record.

Abstract: Determining proportionate use of system resources by applications executing in a shared hosting environment, including executing monitor agents, one monitor agent for one or more instances of the applications, including collecting by the monitor agents data describing each instance of use of a system resource by an instance of the applications; storing by the monitor agents the collected data in data records, each data record representing a use of the system resources by a using instance of an application, the using instance comprising an instance of an application that uses a resource as represented by a data record; and storing by the monitor agents in the data records monitor tags, the monitor tags identifying each data record and identifying each using instance of an application for each data record.

Abstract: A system, method and program for troubleshooting a problem with an application. An application server which is supposed to be executing the application and a database or a server which manages the database are identified. The application, when executing, obtains data from the database to respond to a client request. The application server, database or database server, and a connection between the application server and the database or database server are generated and displayed or printed. Also, one or more hyperlinks to automatically send a hardware, software, or network status inquiry to the application server to test operability of the application server and/or a connection to the application server and automatically send a hardware, software, or network status inquiry to the database server to test operability of the database server and/or a connection to the database server are generated and displayed or printed.

Abstract: A system, method and program for troubleshooting a problem with an application. An application server which is supposed to be executing the application and a database or a server which manages the database are identified. The application, when executing, obtains data from the database to respond to a client request. The application server, database or database server, and a connection between the application server and the database or database server are generated and displayed or printed. Also, one or more hyperlinks to automatically send a hardware, software, or network status inquiry to the application server to test operability of the application server and/or a connection to the application server and automatically send a hardware, software, or network status inquiry to the database server to test operability of the database server and/or a connection to the database server are generated and displayed or printed.