Patents by Inventor Christopher James Cobley

Christopher James Cobley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ruthenium complexes and their use in asymmetric hydrogenation
    Patent number: 6528687
    Abstract: A process for the preparation of an enantiomerically enriched chiral amine of formula (10), or the opposite enantiomer thereof, from an inline of formula (11) wherein (i) R1 is aryl, R2 is alkyl and R3 is aryl or aryl-CH2—, or (iii) R2 is linked with R1 and/or R3 to form one or more rings and R3 or R1 (if not in a ring) is H or a non-interfering organic group, the number of C atoms in each of R1, R2 and R3 being up to 30, comprises asymmetric hydrogenation of the imine in the presence of a base and, as catalyst, a ruthenium complex of a chiral diphosphine and a chiral diamine.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: March 4, 2003
    Assignee: Chirotech Technology Limited
    Inventors: Christopher James Cobley, Julian Paul Henschke, James Andrew Ramsden
  • Process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4] benzothiadiazine
    Patent number: 6518422
    Abstract: Process for the industrial synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine of formula (I): by enantioselective catalytic hydrogenation of 5,5-dioxo-2,3-dihydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: February 11, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Elsa Foucher, Gilles Thominot, Jean-Pierre Lecouve, James Andrew Ramsden, Christopher James Cobley
  • Process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4] benzothiadiazine
    Publication number: 20020161222
    Abstract: Process for the industrial synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazine of formula (I): 1
    Type: Application
    Filed: April 18, 2002
    Publication date: October 31, 2002
    Inventors: Elsa Foucher, Gilles Thominot, Jean-Pierre Lecouve, James Andrew Ramsden, Christopher James Cobley
  • Ruthenium complexes and their use in asymmetric hydrogenation
    Publication number: 20020095056
    Abstract: A process for the preparation of an enantiomerically enriched chiral amine of formula (10), or the opposite enantiomer thereof, from an inline of formula (11) 1
    Type: Application
    Filed: July 23, 2001
    Publication date: July 18, 2002
    Inventors: Christopher James Cobley, Julian Paul Henschke, James Andrew Ramsden