Patents by Inventor Christopher James DONNELLY

Christopher James DONNELLY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optogenetic induction of neurodegenerative disease pathologies
    Patent number: 11945847
    Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: April 2, 2024
    Assignee: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Christopher James Donnelly, Jacob R. Mann
  • OPTOGENETIC INDUCTION OF NEURODEGENERATIVE DISEASE PATHOLOGIES
    Publication number: 20210139547
    Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.
    Type: Application
    Filed: March 7, 2018
    Publication date: May 13, 2021
    Inventors: Christopher James DONNELLY, Jacob R. MANN
  • OPTOGENETIC INDUCTION OF MEMBRANELESS ORGANELLES
    Publication number: 20200224204
    Abstract: The present disclosure relates to compounds, compositions, and methods for the induction of membraneless organelles.
    Type: Application
    Filed: August 17, 2018
    Publication date: July 16, 2020
    Inventors: Christopher James DONNELLY, Joseph Patrick CLARKE