Patents by Inventor Christopher James Lock

Christopher James Lock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYLCARBOXAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Publication number: 20260085073
    Abstract: The invention provides pyrazolylcarboxamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein I (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.
    Type: Application
    Filed: September 12, 2023
    Publication date: March 26, 2026
    Inventors: Kenneth G. Carson, Geraldine Cirillo Harriman, Arwel Lewis, Gabriele Fumagalli, Benjamin Paul Whittaker, Alison Jones, Robert Stuart Laurie Chapman, Maria Angel Palomero-Vazquez, Riccardo Guareschi, Christopher James Lock, James Henry Lewis, Antonio Dore, Alicia Jayne Carey
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 10307422
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: June 4, 2019
    Assignee: USHER III INITIATIVE, INC.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte
  • AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
    Publication number: 20190046515
    Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Inventors: PETER MACHIN, ANDREW SHARPE, CHRISTOPHER JAMES LOCK, MARK S. CHAMBERS, ALASTAIR HODGES, VIVIENNE ALLEN, JOHN M. ELLARD
  • Amido thiadiazole derivatives as NADPH oxidase inhibitors
    Patent number: 10130619
    Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 20, 2018
    Assignee: GENKYOTEX SUISSE SA
    Inventors: Peter Machin, Andrew Sharpe, Christopher James Lock, Mark S. Chambers, Alastair Hodges, Vivienne Allen, John M. Ellard
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20180207159
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Roland Werner BÜRLI, William Rameshchandra Krishna ESMIEU, Christopher James LOCK, Karine Fabienne MALAGU, Andrew Pate OWENS, William E. HARTE
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 9925187
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 27, 2018
    Assignee: USHER III INITIATIVE, INC.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte
  • AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS
    Publication number: 20170348296
    Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).
    Type: Application
    Filed: December 16, 2015
    Publication date: December 7, 2017
    Inventors: PETER MACHIN, ANDREW SHARPE, CHRISTOPHER JAMES LOCK, MARK S. CHAMBERS, ALASTAIR HODGES, VIVIENNE ALLEN, JOHN M. ELLARD
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 9783545
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 10, 2017
    Assignee: USHER III INITIATIVE, INC.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E Harte
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20170143718
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: December 12, 2016
    Publication date: May 25, 2017
    Inventors: Roland Werner BÜRLI, William ESMIEU, Christopher James LOCK, Karine Fabienne MALAGU, Andrew Pate OWENS, William E. HARTE
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 9549910
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: January 24, 2017
    Assignee: USHER III INITIATIVE, INC.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20160272647
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: April 29, 2016
    Publication date: September 22, 2016
    Inventors: Roland Werner BÜRLI, William Rameshchandra Krishna ESMIEU, Christopher James LOCK, Karine Fabienne MALAGU, Andrew Pate Owens, William E. HARTE
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
    Patent number: 9371332
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: June 21, 2016
    Assignee: Usher III Initiative, Inc.
    Inventors: Roland Werner Bürli, William Rameschandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E Harte
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20160158172
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: December 28, 2015
    Publication date: June 9, 2016
    Inventors: Roland Werner BÜRLI, William Rameshchandra Krishna ESMIEU, Christopher James LOCK, Karine Fabienne MALAGU, Andrew Pate OWENS, William E. HARTE
  • Pyrazolopyridazines and methods for treating retinal degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 9260381
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: February 16, 2016
    Assignee: USHER III INITIATIVE, INC.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E Harte
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
    Patent number: 9227976
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: January 5, 2016
    Assignee: Usher III Initiative, Inc.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E Harte
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20150266812
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Inventors: Roland Werner BÜRLI, William Rameshchandra Krishna ESMIEU, Christopher James LOCK, Karine Fabienne MALAGU, Andrew Pate OWENS, William E. HARTE
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20150265617
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Inventors: Roland Werner BÜRLI, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte
  • Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher Syndrome
    Patent number: 9079909
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 14, 2015
    Assignee: Usher III Initiative, Inc.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E Harte
  • Pyrazolopyridazines and methods for treating retinal-degerative diseases and hearing loss associated with usher syndrome
    Patent number: 8765762
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 1, 2014
    Assignee: Usher III, Initiative, Inc.
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte
  • PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME
    Publication number: 20140121205
    Abstract: Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 1, 2014
    Applicant: Usher III Initiative
    Inventors: Roland Werner Bürli, William Rameshchandra Krishna Esmieu, Christopher James Lock, Karine Fabienne Malagu, Andrew Pate Owens, William E. Harte