Abstract: The present disclosure relates to compounds, compositions, and methods for the inducing neurodegenerative disease pathologies. In one aspect, disclosed herein is a nucleotide sequence encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a neurodegenerative disease in target protein. Disclosed herein is a method of inducing a neurodegenerative disease pathology in a cell, comprising the steps: introducing into the cell an expression vector encoding a chimeric polypeptide, comprising: a first nucleotide sequence encoding a light-induced oligomerization domain and a second nucleotide sequence encoding a low complexity domain from a neurodegenerative disease target protein, wherein the first nucleotide sequence is operably linked to a promoter; expressing the chimeric polypeptide; and inducing oligomerization of the chimeric polypeptide by stimulation with blue light.

Abstract: Embodiments of dispensers for dispensing wet wipes are disclosed herein. An exemplary wipes dispenser includes a container, having an opening, a cap, and a first wipe engagement member. The first wipes engagement member includes an opening therethrough. The first wipes engagement member is configured to provide sufficient force on a wipe to prevent the wipe from falling back into the container. A second wipes engagement member is also included. The second wipes engagement member located away from the first wipes engagement member. The second wipes engagement member includes a pull through portion and a grip portion. An access point is located between the first wipes engagement member and the second wipes engagement member. The access point configured to allow a user to grip a lead edge of a wipe as the wipe is threaded through the first wipes engagement member.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser having a nozzle with a wear indicator includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes, a receiving member connected to the container, and an outlet nozzle housing for holding an elastomeric outlet nozzle. The elastomeric outlet nozzle includes a wear indictor that provides a visual indication that the nozzle should be replaced.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes and a self-orientating outlet nozzle. The self-orientating outlet nozzle includes a moveable outlet opening. The moveable outlet opening aligns with the direction of pull of the wipe when the wipe is pulled out of the dispenser at an angle that is not substantially vertical.

Abstract: Embodiments of dispensers for dispensing wet wipes are disclosed herein. An exemplary wipes dispenser includes a container, having an opening, a cap, and a first wipe engagement member. The first wipes engagement member includes an opening therethrough. The first wipes engagement member is configured to provide sufficient force on a wipe to prevent the wipe from falling back into the container. A second wipes engagement member is also included. The second wipes engagement member located away from the first wipes engagement member. The second wipes engagement member includes a pull through portion and a grip portion. An access point is located between the first wipes engagement member and the second wipes engagement member. The access point configured to allow a user to grip a lead edge of a wipe as the wipe is threaded through the first wipes engagement member.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser having a nozzle with a wear indicator includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes, a receiving member connected to the container, and an outlet nozzle housing for holding an elastomeric outlet nozzle. The elastomeric outlet nozzle includes a wear indictor that provides a visual indication that the nozzle should be replaced.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes and a self-orientating outlet nozzle. The self-orientating outlet nozzle includes a moveable outlet opening. The moveable outlet opening aligns with the direction of pull of the wipe when the wipe is pulled out of the dispenser at an angle that is not substantially vertical.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes and a self-orientating outlet nozzle. The self-orientating outlet nozzle includes a moveable outlet opening. The moveable outlet opening aligns with the direction of pull of the wipe when the wipe is pulled out of the dispenser at an angle that is not substantially vertical.

Abstract: Exemplary embodiments of wipes dispensers are disclosed herein. An exemplary wipes dispenser includes a container, a plurality of wipes contained within the container, a fluid for wetting the plurality of wipes and a self-orientating outlet nozzle. The self-orientating outlet nozzle includes a moveable outlet opening. The moveable outlet opening aligns with the direction of pull of the wipe when the wipe is pulled out of the dispenser at an angle that is not substantially vertical.