Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a bioreactor. The invention provides a reproducible and robust method and system of determining and controlling the optimal time of infection of host cells using a correlation of process air parameters including Air flow, O2 flow, and respective trends thereof resulting in increased virus yield.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: Compositions and methods are provided for use in controlling souring and corrosion causing prokaryotes, such as SRP, by treating oil and gas field environments or treatment fluids with a newly identified bacterial strain ATCC Accession No. PTA-124262 as a self-propagating whole cell that produces an anti-SRP bacteriocin in situ. In another aspect, the methods use one or more toxic peptides or proteins isolated therefrom in methods to control unwanted prokaryotic growth in these environments.

Abstract: The creped multi-ply tissue products are durable, smooth and have low levels of Slough. In certain instances, the creped multi-ply tissue products are produced using a creping composition comprising a non-crosslinked latex polymer. The creped multi-ply tissue products may have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, such as from about 0.10 to about 2.00 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A computer-implemented method is provided for detecting actionable transaction risks. The method includes grouping an inbound event related to a transaction with a target event group and determining an actionable group of events that are deemed high risk and a non-actionable group of non-actionable events that are deemed low risk. The method also includes evaluating the target event group relative to the actionable and non-actionable groups of events. This includes computing a first distance between the target event group and the non-actionable group and a second distance between the target event group and actionable group. The first distance is compared with the second distance to determine if the target event group, including the inbound event, is closer to the actionable group or to the nonactionable group.

Abstract: Compositions and methods are provided for use in controlling souring and corrosion causing prokaryotes, such as SRP, by treating oil and gas field environments or treatment fluids with a newly identified bacterial strain ATCC Accession No. PTA-124262 as a self-propagating whole cell that produces an anti-SRP bacteriocin in situ. In another aspect, the methods use one or more toxic peptides or proteins isolated therefrom in methods to control unwanted prokaryotic growth in these environments.

Abstract: Compositions and methods are provided for use in controlling souring and corrosion causing prokaryotes, such as SRP, by treating oil and gas field environments or treatment fluids with a newly identified bacterial strain ATCC Accession No. PTA-124262 as a self-propagating whole cell that produces an anti-SRP bacteriocin in situ. In another aspect, the methods use one or more toxic peptides or proteins isolated therefrom in methods to control unwanted prokaryotic growth in these environments.

Abstract: A downhole tool including multiple orifices defining at least a first and a second flow path, and a valve that adjusts to change a ratio of fluid flow between the first and second flow paths, the valve being offset from the multiple orifices by a gap that is adjustable to customize a sensitivity of the change to each adjustment. A method for regulating flow along a first fluid path in a downhole tool includes adjusting a valve relative to multiple orifices that define the first fluid path and a second fluid path, said adjusting changing a ratio of fluid flow between the first and second flow paths, and adjusting a gap between the valve and the multiple orifices to modify a sensitivity of the change to each adjustment.

Abstract: Compositions and methods are provided for use in controlling souring and corrosion causing prokaryotes, such as SRP, by treating oil and gas field environments or treatment fluids with a newly identified bacterial strain ATCC Accession No. PTA-124262 as a self-propagating whole cell that produces an anti-SRP bacteriocin in situ. In another aspect, the methods use one or more toxic peptides or proteins isolated therefrom in methods to control unwanted prokaryotic growth in these environments.

Abstract: Systems and methods divide flow in a wellbore into a plurality of flow paths. A first one of the flow paths extends to a down-hole turbine that is responsive to fluid flow to provide rotational motion to an electric generator or other down-hole tool. A second flow path may extend to an independent down-hole tool, to a port communicating with the wellbore, to a bypass channel extending around the turbine, or to any other down-hole location. The turbine includes a stator having adjustable blades such that an open flow area through the turbine may be selectively controlled. A flow distribution between the first and second flow paths can be controlled where specific flow areas are needed at specific flow rates, for example.

Abstract: Directional control of a rotary steerable drilling assembly can be facilitated by a flow control module for maintaining a geostationary position or orientation of components of the assembly. The drilling assembly can include a bit shaft and an offset mandrel for adjusting a longitudinal axis of the bit shaft. A drive mechanism can rotate the offset mandrel independently of the bit shaft to maintain the offset mandrel in a geostationary position or orientation relative to a formation of the earth and/or a wellbore. A flow control module controllably directs a fluid flow to the drive mechanism. The flow control module can include an inner body and an outer body, defining an annulus there between and one or more blades within the annulus, each of the blades being rotatable to provide a range of angles with respect to a longitudinal axis of the flow control module.

Abstract: Systems and methods divide flow in a wellbore into a plurality of flow paths. A first one of the flow paths extends to a down-hole turbine that is responsive to fluid flow to provide rotational motion to an electric generator or other down-hole tool. A second flow path may extend to an independent down-hole tool, to a port communicating with the wellbore, to a bypass channel extending around the turbine, or to any other down-hole location. The turbine includes a stator having adjustable blades such that an open flow area through the turbine may be selectively controlled. A flow distribution between the first and second flow paths can be controlled where specific flow areas are needed at specific flow rates, for example.

Abstract: A downhole tool including multiple orifices defining at least a first and a second flow path, and a valve that adjusts to change a ratio of fluid flow between the first and second flow paths, the valve being offset from the multiple orifices by a gap that is adjustable to customize a sensitivity of the change to each adjustment. A method for regulating flow along a first fluid path in a downhole tool includes adjusting a valve relative to multiple orifices that define the first fluid path and a second fluid path, said adjusting changing a ratio of fluid flow between the first and second flow paths, and adjusting a gap between the valve and the multiple orifices to modify a sensitivity of the change to each adjustment.

Abstract: Directional control of a rotary steerable drilling assembly can be facilitated by a flow control module for maintaining a geostationary position or orientation of components of the assembly. The drilling assembly can include a bit shaft and an offset mandrel for adjusting a longitudinal axis of the bit shaft. A drive mechanism can rotate the offset mandrel independently of the bit shaft to maintain the offset mandrel in a geostationary position or orientation relative to a formation of the earth and/or a wellbore. A flow control module controllably directs a fluid flow to the drive mechanism. The flow control module can include an inner body and an outer body, defining an annulus there between and one or more blades within the annulus, each of the blades being rotatable to provide a range of angles with respect to a longitudinal axis of the flow control module.