Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: A method of providing airway clearance therapy to a patient includes receiving an expiratory airstream from the patient in a chamber, causing a back pressure to be created in the chamber (10) in response to receiving the expiratory airstream, causing a one-way valve, such as a magnetic duckbill valve (26), located downstream of the chamber to open only in response to the back pressure being at least equal to a certain predetermined level, causing a vibratory effect to be generated downstream of the one-way valve, for example using a vibratory ball check valve (32), when the one-way valve is open and in response to the expiratory air-stream passing therethrough, and delivering a percussive sensation to the patient through the chamber responsive to the vibratory effect.

Abstract: Apparatus for refilling and subsequently sealing an ink jet cartridge. The apparatus including a body with a pointed distal end which can be pushed through a tape covering the fill hole for the cartridge. A recess is provided in the proximal end of the apparatus for connection to a syringe or a feed pipe. A passage connects with the recess and also a radial passage adjacent the distal end of the apparatus. A resilient sleeve locates in a circumferential recess extending around the apparatus and covering the end of the passage in a rest condition to provide a one way valve.

Abstract: Apparatus for refilling and subsequently sealing an ink jet cartridge. The apparatus including a body with a pointed distal end which can be pushed through a tape covering the fill hole for the cartridge. A recess is provided in the proximal end of the apparatus for connection to a syringe or a feed pipe. A passage connects with the recess and also a radial passage adjacent the distal end of the apparatus. A resilient sleeve locates in a circumferential recess extending around the apparatus and covering the end of the passage in a rest condition to provide a one way valve.

Abstract: An ophthalmic lens mold includes a first mold half having a front side and a back side. The front side defines an optical surface. A second mold half has a front side defining an optical surface. Upon alignment of the first mold half with respect to the second mold half so that the front sides oppose each other, a mold cavity is formed between the front sides to form an ophthalmic lens therein from a moldable material. The first mold half includes a first section that transmits curing light and that extends from the back side to the front side. The first section includes at an area of the first mold half optical surface enclosed by an outermost circumference of the ophthalmic lens. A second section is co-molded with the first section and blocks the light.

Abstract: A washing system using a washing implement including looped filaments, together with a surfactant-based cleanser.

Abstract: A washing system using a washing implement including floppy filaments free at one end, which may be in the shape of a ball, together with a surfactant-based cleanser.

Abstract: A disinfection apparatus including a container; a cap having an article-retaining means, a sealing means and a catalytic element-retaining means affixed thereto; and a catalytic element. The disinfection apparatus has particular utility in the disinfection of contact lenses with hydrogen peroxide solutions. Also disclosed are venting and sealing components, catalytic elements, molded article-retaining assemblies, and catalytic element formation methods.