Patents by Inventor Christopher John Brown

Christopher John Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probes for imaging huntingtin protein
    Patent number: 12258355
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: March 25, 2025
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Samuel Coe, Peter David Johnson, Michael Edward Prime, Christopher John Brown, Sébastien René Gabriel Galan, Paul Richard Giles, Jonathan Bard, Elise Lucienne Paulette Gadouleau, Thomas Martin Krülle, Daniel Clark-Frew, John Wityak, Alex Kiselyov, Sarah Hayes
  • Modulators of the integrated stress response pathway
    Patent number: 12258338
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: March 25, 2025
    Assignee: Evotec International GmbH
    Inventors: Holly Atton, Christopher John Brown, James Lindsay Carr, Serge Convers-Reignier, Michael Corr, Marissa Flower, Christopher Francis Palmer, Irena Reboule, Mohamad Sabbah, Scott Sadler, Jonathan Shine, Daryl Simon Walter
  • Probes for imaging huntingtin protein
    Patent number: 12036291
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: July 16, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Thomas Martin Krülle, Daniel Clark-Frew, Sarah Hayes
  • Compounds and probes for imaging huntingtin protein
    Patent number: 11992535
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 28, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Christopher John Brown, Sarah Hayes, Adrian Kotey, Matthew Robert Mills, Michael Edward Prime
  • Probes for imaging Huntingtin protein
    Patent number: 11851446
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: December 26, 2023
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Daniel Clark-Frew
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20230391763
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4f, X1, X2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: October 21, 2021
    Publication date: December 7, 2023
    Applicant: Evotec International GmbH
    Inventors: Holly Victoria ATTON, Christopher John Brown, Serge Convers-Reignier, Christopher Francis Palmer, Mohamad Sabbah, Daryl Simon Walter
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20230391725
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R4f, R5, R6 have the meaning as indicated in the description and claims The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: October 21, 2021
    Publication date: December 7, 2023
    Applicant: Evotec International GmbH
    Inventors: Holly Victoria Atton, Christopher John Brown, James Lindsay Carr, Gert-Jan Hofman, Mohamad Sabbah, Daryl Simon Walter
  • Legacy time division multiplexing (TDM) service support in a packet network and on a packet network element
    Patent number: 11736216
    Abstract: A network element includes at least two Time Division Multiplexing (TDM) modules each including a TDM client interface, TDM processing circuitry, and circuit emulation circuitry; and a packet switch fabric connected to the at least two TDM modules in a Link Aggregation Group (LAG) for a protected TDM service, and configured to output a packet interface, wherein the protected TDM service is provided as a single packetized TDM stream via the packet interface from the packet switch fabric.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: August 22, 2023
    Assignee: Ciena Corporation
    Inventors: Christopher John Brown, Craig Donald Suitor, Matthew Yuen, Alexander Young, Sitaram Patro, Stuart White
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20230212190
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: August 5, 2022
    Publication date: July 6, 2023
    Inventors: Celia DOMINGUEZ, Samuel COE, Peter David JOHNSON, Michael Edward PRIME, Christopher John BROWN, Sébastien René Gabriel GALAN, Paul Richard GILES, Jonathan BARD, Elise Lucienne Paulette GADOULEAU, Thomas Martin KRÜLLE, Daniel CLARK-FREW, John WITYAK, Alex KISELYOV, Sarah HAYES
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20230125481
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra4, Ra5, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: January 26, 2021
    Publication date: April 27, 2023
    Inventors: Christopher John BROWN, James Lindsay CARR, Mohamad SABBAH, Jeffrey Michael SCHKERYANTZ, Daryl Simon WALTER
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20230129907
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra3, Ra4, Ra5, Ra6, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: March 10, 2021
    Publication date: April 27, 2023
    Inventors: Holly Victoria ATTON, Christopher John BROWN, James Lindsay CARR, Scott Alexander SADLER, Jonathan Paul SHINE, Daryl Simon WALTER
  • ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20220339302
    Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Application
    Filed: April 7, 2022
    Publication date: October 27, 2022
    Inventors: Longbin Liu, Celia Dominguez, Jonathan Bard, Christopher John Brown, Xuemei Chen, Daniel Clark-Frew, Matthew Robert Mills, Peter David Johnson, Elise Gadouleau
  • Peptides and Compounds that Bind to Elongation Initiation Factor 4E
    Publication number: 20220242906
    Abstract: A peptide that binds to elongation initiation factor 4E (eIF4E) comprising the amino acid sequence CEX1GX2X3X4X5C (SEQ ID NO: 1), where X1 is an amino acid selected from the group consisting of threonine (T), methionine (M) or leucine (L), X2 and X3 is an amino acid selected from the group consisting of phenylalanine (F), modified phenylalanine and tyrosine (Y), X4 and X5 is any amino acid, wherein the two cysteine residues are joined by a disulphide bond. Further, pharmaceutical compositions and uses of the peptide, and pharmaceutical compositions are provided.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 4, 2022
    Inventors: Simon Ng, Christopher John Brown
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20220227747
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: April 22, 2020
    Publication date: July 21, 2022
    Inventors: Holly ATTON, Christopher John BROWN, James Lindsay CARR, Serge CONVERS-REIGNIER, Michael CORR, Marissa FLOWER, Christopher Francis PALMER, Irena REBOULE, Mohamad SABBAH, Scott SADLER, Jonathan SHINE, Daryl Simon WALTER
  • MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
    Publication number: 20220213078
    Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1 to R3, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing one or more diseases or disorders associated with integrated stress response.
    Type: Application
    Filed: April 22, 2020
    Publication date: July 7, 2022
    Inventors: Christopher John BROWN, Irena Doly REBOULE, York RUDHARD, Mohamad SABBAH, Daryl Simon WALTER
  • Probes for imaging huntingtin protein
    Patent number: 11344637
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: May 31, 2022
    Assignee: CHDI FOUNDATION, INC.
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Thomas Martin Krulle, Daniel Clark-Frew, Duane Higgins, Matthew Robert Mills, Richard Waldron Marston, Samuel Coe, Samantha Brown, Sarah Hayes
  • Non-membrane disruptive P53 activating stapled peptides
    Patent number: 11319344
    Abstract: The present invention relates to non-membrane disruptive and p53 activating stapled peptides, as well as methods of treatment of cancer involving the use of these peptides. In one embodiment, the peptide comprises or consist of the amino acid sequence of TSFXaa1EY-WXaa3LLXaa2, where Xaa1 is (R)-2-(7?-octenyl)alanine or derivative thereof, or is (R)-2-(4?-pentenyl)alanine or derivative thereof; and Xaa2 and Xaa3 are independently any type of amino acid or modified amino acid. In another embodiment, the peptide comprising or consisting of the amino acid sequence of TSFXaa1EYW Xaa3LLXaa2ENXaa5, wherein Xaa1 and Xaa3 are any type of amino acid or modified amino acid; Xaa2 is S, or P, or (S)-2-(4?-pentenyl)alanine or a derivative of (S)-2-(4?-pentenyl)alanine; and wherein Xaa5 is F or Y.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: May 3, 2022
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Yaw Sing Tan, Christopher John Brown, Chandra S. Verma, Fernando Jose Ferrer Gago, David P. Lane, Thomas Joseph
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20210380608
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 9, 2021
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Alex Kiselyov, Christopher John Brown, Michael Edward Prime, Peter David Johnson, Daniel Clark-Frew
  • PROBES FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20210379211
    Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
    Type: Application
    Filed: June 21, 2021
    Publication date: December 9, 2021
    Inventors: Celia Dominguez, John Wityak, Jonathan Bard, Christopher John Brown, Thomas Martin Krulle, Daniel Clark-Frew, Sarah Hayes
  • Legacy Time Division Multiplexing (TDM) service support in a packet network and on a packet network element
    Publication number: 20210351855
    Abstract: A network element includes at least two Time Division Multiplexing (TDM) modules each including a TDM client interface, TDM processing circuitry, and circuit emulation circuitry; and a packet switch fabric connected to the at least two TDM modules in a Link Aggregation Group (LAG) for a protected TDM service, and configured to output a packet interface, wherein the protected TDM service is provided as a single packetized TDM stream via the packet interface from the packet switch fabric.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 11, 2021
    Inventors: Christopher John Brown, Craig Donald Suitor, Matthew Yuen, Alexander Young, Sitaram Patro, Stuart White