Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A robust and ergonomic fluid dispenser (1) suitable for dispensing cosmetic compositions and comprising a cylindrical outer body, an upper section having a domed applicator surface, a cylindrical lower section that forms a protective cover for a refill cartridge (13), a rotatable actuator collar (4), an axially mobile pump housing (6) carrying a pump engine inside, the rotatable actuator collar (4) and axially mobile pump housing (6) interacting by means of a cam track on one and a cam follower on the other, the pump housing (6) being reversibly attached to the refill cartridge (13), the cam follower (7) on the pump housing (6) rising on rotation of the actuator collar (4) in a first direction and thereby lifting the pump housing (6) and the refill cartridge (13) to a raised position and actuating the pump engine, the cam follower (7) on the pump housing (6) falling on rotation of the actuator collar (4) in a second direction to a rest position and thereby lowering the pump housing (6) and the refill cartridg

Abstract: An aerosol dispenser comprising a pressurised aerosol can and a closure comprising an aerosol valve held within a retention chassis, the retention chassis being associated with a flexible sealing collar designed to radially surround the retention chassis and to seal against the edge of an opening in the aerosol can, wherein the retention chassis is axially moveable relative to the sealing collar and wherein the sealing collar is of outer diameter greater than the inner diameter of the opening in the aerosol can and is sufficiently flexible to flex through the opening in the aerosol can when the retention chassis is in a first axial position relative to the sealing collar and wherein the sealing collar is firmly held against the edge of the opening in the aerosol can when the retention chassis is in a second axial position relative to the sealing collar.

Abstract: A robust and ergonomic fluid dispenser (1) suitable for dispensing cosmetic compositions and comprising a cylindrical outer body, an upper section having a domed applicator surface, a cylindrical lower section that forms a protective cover for a refill cartridge (13), a rotatable actuator collar (4), an axially mobile pump housing (6) carrying a pump engine inside, the rotatable actuator collar (4) and axially mobile pump housing (6) interacting by means of a cam track on one and a cam follower on the other, the pump housing (6) being reversibly attached to the refill cartridge (13), the cam follower (7) on the pump housing (6) rising on rotation of the actuator collar (4) in a first direction and thereby lifting the pump housing (6) and the refill cartridge (13) to a raised position and actuating the pump engine, the cam follower (7) on the pump housing (6) falling on rotation of the actuator collar (4) in a second direction to a rest position and thereby lowering the pump housing (6) and the refill cartridg

Abstract: An aerosol dispenser (1) comprising a pressurised aerosol can (2) and a closure (3) comprising an aerosol valve (4) held within a retention chassis (5), said retention chassis (5) being associated with a flexible sealing collar (6) designed to radially surround the retention chassis (5) and to seal against the edge of an opening (7) in the aerosol can (2), wherein the retention chassis (5) is axially moveable relative to the sealing collar (6) and wherein the sealing collar (6) is of outer 7A diameter greater than the inner diameter of the opening (7) in the aerosol can (2) and is sufficiently flexible to flex through the opening (7) in the aerosol can (2) when the retention chassis (5) is in a first axial position relative to the sealing collar (6) and wherein the sealing collar (6) is firmly held 2 against the edge (7) of the opening (8) in the aerosol can (2) when the retention chassis (5) is in a second axial position relative to the sealing collar (6).

Abstract: A dispenser (1) suitable for delivery of a cream, gel or soft solid composition comprising: (vi) a convex applicator surface (6) at an upper end; (vii) a replaceable cartridge (12) containing a composition to be dispensed; (viii) a passageway between the cartridge and the applicator surface; (ix) a drive mechanism for forcing the composition from the cartridge through the passageway and onto the applicator surface; and (x) an outer body (3) containing features (ii) to (iv); the drive mechanism comprising a dial unit (4) and a plunger (47), rotation of the dial unit (4) in a first direction advancing the plunger (47) axially upwards, the plunger (47) acting upon a piston seal (8) at the base of the replaceable cartridge (12), thereby forcing the contained composition upwards and outwards through the passageway and onto the applicator surface (6); rotation of the dial unit (4) in a second direction, counter to the first, rotationally re-setting the dial unit (4) relative to the plunger (47) in readiness for a f

Abstract: A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Abstract: An antiperspirant composition and a dispenser therefor, the composition being a gel, cream or soft solid of viscosity from 3000 mPa·s to 5200 mPa·s at a shear rate of 16/s comprising a non-pore blocking inhibitor of perspiration and the dispenser comprising a dome-shaped applicator surface of radius of curvature decreasing from a maximum of from 25 to 60 mm at its top/center to a value of from 75 to 95% of its maximum value at a distance of 1 cm from its top/center.

Abstract: The invention provides a container (10) for the packaging of a fluent product (P) which off-gases, the container comprising: a container body (11) for receiving and storing product and a removable lid (12) for closing the container body; in which the lid is provided with a venting assembly (20, 23a, 23b, 24) extending into the container body; in which the venting assembly has a closed position which is effective to close the container body and a venting position permitting the venting of gas from the container body; whereby, when the container body is partially filled with a fluent product which off-gases, the venting assembly moves to the venting position in response to excessive pressure from accumulated gas, and reverts to the closed position upon release of the excessive pressure, thus effecting periodic venting of the container body; and whereby the spatial arrangement of the venting assembly within the container body provides for venting of the container body independently of the orientation of the cont

Abstract: A method and system for providing a drug delivery device. The drug delivery device comprises a dose setting mechanism comprising a spindle and a cartridge holder coupled to the dose setting mechanism. The cartridge holder comprising a cartridge having a movable bung at one end of the cartridge. The cartridge holder must be rotated before a dose may set with the dose setting mechanism.

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir (22) when the needle guard (42) is retracted. The needle guard (42) prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Abstract: A dispenser head for an aerosol can and a method of assembly of the same, the dispenser head comprising a chassis attached to the associated aerosol can and a spray-through cap attached thereto, the chassis comprising a platform capable of axial movement and a flexible spray channel centrally located thereon.

Abstract: An antiperspirant composition and a dispenser therefor, the composition being a gel, cream or soft solid of viscosity from 3000 mPa·s to 5200 mPa·s at a shear rate of 16/s comprising a non-pore blocking inhibitor of perspiration and the dispenser comprising a dome-shaped applicator surface of radius of curvature decreasing from a maximum of from 25 to 60 mm at its top/centre to a value of from 75 to 95% of its maximum value at a distance of 1 cm from its top/centre.

Abstract: A dispenser (1) suitable for delivery of a cream, gel or soft solid composition comprising: (vi) a convex applicator surface (6) at an upper end; (vii) a replaceable cartridge (12) containing a composition to be dispensed; (viii) a passageway between the cartridge and the applicator surface; (ix) a drive mechanism for forcing the composition from the cartridge through the passageway and onto the applicator surface; and (x) an outer body (3) containing features (ii) to (iv); the drive mechanism comprising a dial unit (4) and a plunger (47), rotation of the dial unit (4) in a first direction advancing the plunger (47) axially upwards, the plunger (47) acting upon a piston seal (8) at the base of the replaceable cartridge (12), thereby forcing the contained composition upwards and outwards through the passageway and onto the applicator surface (6); rotation of the dial unit (4) in a second direction, counter to the first, rotationally re-setting the dial unit (4) relative to the plunger (47) in readiness for a f

Abstract: A sprayhead for use with an aerosol container, the sprayhead including a chassis capable of firm attachment to the container; a rotatable circular collar; a spray channel and associated actuator button; and an over-cap; the rotatable circular collar being rotatable between a first and second position, wherein, when the rotatable circular collar is in the first position, a holding feature of the rotatable circular collar interacts with a holding feature of the chassis and wherein the rotatable circular collar further includes a projection that interacts with a non-rotating feature of the overcap to produce an audible signal when the rotatable circular collar is rotated between its first and second position.

Abstract: The invention provides a container (10) for the packaging of a fluent product (P) which off-gases, the container comprising: a container body (11) for receiving and storing product and a removable lid (12) for closing the container body; in which the lid is provided with a venting assembly (20, 23a, 23b, 24) extending into the container body; in which the venting assembly has a closed position which is effective to close the container body and a venting position permitting the venting of gas from the container body; whereby, when the container body is partially filled with a fluent product which off-gases, the venting assembly moves to the venting position in response to excessive pressure from accumulated gas, and reverts to the closed position upon release of the excessive pressure, thus effecting periodic venting of the container body; and whereby the spatial arrangement of the venting assembly within the container body provides for venting of the container body independently of the orientation of the cont

Abstract: A resettable dosing mechanism comprises a dose button and a dial grip operatively coupled to the dose button. A spindle acts on a bung of a cartridge and a driver is operatively coupled between the dose button and the spindle. During an injection of the dose, the dose button moves in an axial direction to cause the spindle to administer the dose. During resetting of the dose setting mechanism, the spindle is retracted back into the dose setting mechanism.

Abstract: A dispenser head for an aerosol can and a method of assembly of the same, the dispenser head comprising a chassis attached to the associated aerosol can and a spray-through cap attached thereto, the chassis comprising a platform capable of axial movement and a flexible spray channel centrally located thereon.

Abstract: A sprayhead for use with an aerosol container, the sprayhead including: a chassis; a rotatable circular collar; and a spray channel and associated actuator button, the spray channel passing through a central aperture in a bridge spanning a diameter of the collar, and being connectable to the aerosol container; the chassis including an annular skirt that, on a lower internal surface thereof, an annular valve cup securing bead that, when the sprayhead is attached to an aerosol container, grips the container such that the torque required to turn the chassis around the container is at least twice that required to turn the rotatable circular collar around the chassis.