Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: A golf club head has a body defining a crown opening and a sole opening, a forward portion of the crown opening having a lip recessed below an outer surface of the crown and extending rearwardly. A composite crown insert is connected to the lip and covers the crown opening. A ratio of an outer surface area of the body and a combined outer surface area of the crown and sole inserts is less than 0.9. The club head has a crown height as measured relative to a ground plane at address, and there is a first crown height at a face-to-crown transition zone, a second crown height at a crown-to-skirt transition zone, and a maximum crown height that is greater than the first and second crown heights, the maximum crown height being located on the crown insert at or rearward of the lip.

Abstract: The invention relates to a device for controlling a plurality of nuclear reactors, comprising, for each nuclear reactor, a plurality of sensors for measuring operating parameters as well a system for controlling the nuclear reactor.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: A common point of purchase (CPP) system for identifying a common point of purchases involved in fraudulent or unauthorized payment transactions is provided. The CPP system includes a common point of purchase (CPP) computing device that is configured to receive transaction data and build a table in a database, the table including recording pairing merchant and account identifiers. The CPP computing device is also configured to receive a list of flagged account identifiers and compare the list to the table. The CPP computing device is further configured to compute a metric and build a merchant profile for each merchant, for display at a client system.

Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: Disclosed golf club heads include a body defining an interior cavity, a face, a sole, a crown, and a hosel. Certain embodiments include a weight channel positioned in the sole and defining a path along the sole. Some embodiments include a weight member positioned in the weight channel that is configured to be adjusted to any of a range of selectable positions to adjust mass properties of the golf club head. A fastener may be configured to secure the weight member in any of the selectable positions, while the fastener itself, regardless of where the weight member is positioned along the path, may be secured to the body at a fixed location that is independent of the position of the weight member along the path.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: Systems, methods, and apparatus may be provided for providing a medical product assistant to identify a medical product. A first message may be received from a user interface. The first message may indicate a request from a user to identify an object. A portion of the object may be determined using the device's camera. A confidence level associated with a medical product may be generated. The generated confidence level may indicate confidence that the object is the medical product. The generated confidence level may be based on the portion of the object and a product detection model. The product detection model may have been trained using synthetic product detection data that may comprise at least a computer-generated image of the medical product. The object may be identified as the medical product when the confidence level satisfies a threshold.

Abstract: An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk.

Abstract: A portable cooler container is provided. The temperature control system cools a chamber of the container to transport temperature sensitive contents via the container. An electronic display screen on one of the lid and the container body selectively displays an electronic shipping label for the portable cooler container.

Abstract: Examples of the disclosure data enable interactions of a user with an object to be used to improve the classification of the object in mediated reality applications. In examples of the disclosure LiDAR data is obtained from a mediated reality device. The mediated reality device is used by a user and the LiDAR data includes data points representing at least part of an object. Position data relating to a position of the user's hand relative to the object is obtained and interaction data indicating how the user's hand is interacting with the object is also obtained. At least some of the interaction data is obtained from an electromyography device coupled to the user. The position data is used to map the interaction data to the LiDAR data to enable the interaction data to be used to classify the object.

Abstract: A lighting assembly may include a light source and a reflective polarizer overlapping the light source. A portion of light that is incident on the reflective polarizer may not pass through the reflective polarizer and may be reflected back to the light source. The light source may include at least one of a light emitting diode (LED), a micro-LED, an organic light emitting diode (OLED), a micro-OLED, a liquid crystal on silicon (LCoS), or an fLCoS light source. The reflective polarizer may include a polymer birefringent multilayer structure of alternating first layers and second layers. The first layers may each include an isotropic polymer thin film the second layers each include an anisotropic polymer thin film. Various other devices, systems, and methods are also disclosed.

Abstract: An apparatus may include a sense amplifier with a single column select transistor, a local input/output line selectively couplable to a first bit line through the column select transistor, and a read/write gap comprising at least a first transistor and a second transistor. The first transistor may be couplable to a read select signal and a complimentary local input/output line and the second transistor is couplable to the complimentary local input/output line and a global input/output line.

Abstract: According to aspects, hydrogen fueling systems and methods are provided, including vehicle-to-vehicle communication techniques, hydrogen cooling techniques and/or hydrogen dispenser control techniques that facilitate improving aspects of a hydrogen fueling station.

Abstract: A system for making a brine solution is provided comprising: a single conveyor; and a hopper assembly configured to receive a salt and a solvent, the hopper assembly comprising a lower hopper having a shape in which sides of the lower hopper direct any solid contents of the lower hopper, under a force of gravity, towards an entry point of the single conveyor, the hopper assembly further comprising a solvent inlet arranged to spray the salt, wherein the solvent inlet is configured to create a brine solution from a spray of the solvent combined with the salt in the hopper assembly, and wherein the single conveyor is configured to remove debris from the hopper assembly at the entry point of the single conveyor. A novel sediment tank is also provided.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is formed between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering.

Abstract: A transport climate control system for providing climate control to a climate controlled space of a transport unit. The transport climate control circuit includes a compressor, an evaporator and at least two fans. The transport climate control circuit also includes a controller for controlling the transport climate control circuit and for defrosting the evaporator coil. When a defrost event is triggered, the controller instructs the transport climate control circuit to supply heat to or around one section of the evaporator coil, and independently controls each of the at least two fans to move the air around the evaporator coil in a controlled direction so that heat from the one section of the evaporator coil is used to convectively heat the inlet of the evaporator coil.