Patents by Inventor Christopher Joseph Schofield
Christopher Joseph Schofield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8445224Abstract: The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO.Type: GrantFiled: June 20, 2008Date of Patent: May 21, 2013Assignee: Isis Innovation LimitedInventors: Frances Mary Ashcroft, Christopher Paul Ponting, Thomas Gerken, Christopher Joseph Schofield
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Patent number: 8148100Abstract: The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.Type: GrantFiled: September 25, 2006Date of Patent: April 3, 2012Assignee: ISIS Innovation LimitedInventors: Christopher Joseph Schofield, Michael Arnold McDonough, Nicolas Joseph Jean Granatino
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Publication number: 20110130449Abstract: The invention provides a method for assaying Jmjd6 activity.Type: ApplicationFiled: May 21, 2009Publication date: June 2, 2011Applicants: Isis Innovation Limited, Ludwig-Maximilians-Universitat Munchen Geschwister-Scholl-Platz 1Inventors: Christopher Joseph Schofield, Celia Jane Webby, Angelika Beottger, Alexander Wolf
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Publication number: 20100272726Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.Type: ApplicationFiled: January 12, 2010Publication date: October 28, 2010Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
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Publication number: 20100216832Abstract: The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO.Type: ApplicationFiled: June 20, 2008Publication date: August 26, 2010Inventors: Frances Mary Ashcroft, Christopher Paul Ponting, Thomas Gerken, Christopher Joseph Schofield
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Patent number: 7778779Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.Type: GrantFiled: October 16, 2003Date of Patent: August 17, 2010Assignee: Isis Innovation LimitedInventors: Peter John Ratcliffe, Christopher William Pugh, Christopher Joseph Schofield, Kirsty Sarah Hewitson, Jonathan Mark Elkins
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Patent number: 7662854Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.Type: GrantFiled: September 11, 2006Date of Patent: February 16, 2010Assignee: ISIS Innovation LimitedInventors: Christopher Joseph Schofield, Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe
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Patent number: 7638295Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.Type: GrantFiled: March 24, 2005Date of Patent: December 29, 2009Assignee: Isis Innovation LimitedInventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman
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Publication number: 20090286858Abstract: The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.Type: ApplicationFiled: April 30, 2009Publication date: November 19, 2009Applicant: ISIS INNOVATION LIMITEDInventors: Christopher William PUGH, Jonathan Mark GLEADLE, Peter John RATCLIFFE, Christopher Joseph SCHOFIELD, Luke Alexander MCNEILL
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Publication number: 20090208475Abstract: The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.Type: ApplicationFiled: September 25, 2006Publication date: August 20, 2009Applicant: ISIS INNOVATION LIMITEDInventors: Christopher Joseph Schofield, Michael Arnold McDonough, Nicolas Joseph Jean Granatino
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Patent number: 7544480Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.Type: GrantFiled: May 23, 2003Date of Patent: June 9, 2009Assignee: Isis Innovation LimitedInventors: Christopher William Pugh, Jonathan Mark Gleadle, Peter John Ratcliffe, Christopher Joseph Schofield, Luke Alexander McNeill
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Patent number: 7498421Abstract: A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 or —COR4, and each of R1, R2 and R4, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y2 and Y3, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R9, —CO2R9, —CONHR9 or —COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH?C(NHR10)CH((CH2)m CO2R11)(C?O)CH3 or —CH2(C?O)CH((CH2)mCO2R11)(C?O)CH3, R8 is —(CH2)nCO2R12, each of R5 to R7 and R9 to R12, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y4 to Y6, which may be the same orType: GrantFiled: June 30, 2006Date of Patent: March 3, 2009Assignee: Medical Research CouncilInventors: Joseph Floyd Clark, Thomas Andrew Daniel Cadoux-Hudson, Christopher Joseph Schofield
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Publication number: 20080227848Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.Type: ApplicationFiled: March 24, 2005Publication date: September 18, 2008Applicant: Isis Innovation LimitedInventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman
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Patent number: 7098238Abstract: A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 or —COR4, and each of R1, R2 and R4, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y2 and Y3, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R9, —CO2R9, —CONHR9 or —COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH?C(NHR10)CH((CH2)mCO2R11)(C?O)CH3 or —CH2(C?O)CH((CH2)mCO2R11)(C?O)CH3, R8 is —(CH2)nCO2R12, each of R5 to R7 and R9 to R12, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y4 to Y6, which may be the same orType: GrantFiled: February 26, 2001Date of Patent: August 29, 2006Assignee: Medical Research CouncilInventors: Joseph Floyd Clark, Thomas Andrew Daniel Cadoux-Hudson, Christopher Joseph Schofield
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Patent number: 6905849Abstract: The present invention relates to a new process for the synthesis of clavam compounds, in particular clavulanic acid. In one aspect, the invention relates to Streptomyces clavuligerus ?-lactam synthetase polypeptide sand Streptomyces clavuligerus ?-lactam synthetase polynucleotides, recombinant materials thereof and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides.Type: GrantFiled: July 15, 1999Date of Patent: June 14, 2005Assignee: SmithKline Beecham plcInventors: Barry Barton, Heather Jane McNaughton, Christopher Joseph Schofield, Jan Edward Thirkettle
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Publication number: 20040146964Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.Type: ApplicationFiled: January 20, 2004Publication date: July 29, 2004Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
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Publication number: 20030162826Abstract: A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 or —COR4, and each of R1, R2 and R4, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y2 and Y3, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R9, —CO2R9, —CONHR9 or —COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH═C(NHR10)CH((CH2)mCO2R11)(C═O)CH3 or —CH2(C═O)CH((CH2)mCO2R11)(C═O)CH3, R8 is —(CH2),CO2R12, each of R5 to R7 and R9 to R12, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 tType: ApplicationFiled: March 7, 2003Publication date: August 28, 2003Inventors: Joseph Floyd Clark, Thomas Andrew Daniel Cadoux-Hudson, Christopher Joseph Schofield
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Publication number: 20030153549Abstract: The invention relates to compounds of formula (I) wherein each of X, Y and Z, which may be the same or different, represents hydrogen or an unsubstituted or substituted hydrocarbon radical, typically an alkyl, aryl, including heterocyclic aryl, or non-aromatic heterocyclic radical and Y additionally may represent —COWR wherein W represents O, S or NRiv wherein Riv represents hydrogen or a radical R, and R represents hydrogen or an unsubstituted or substituted hydrocarbon radical for use as protease inhibitors, X, Y and Z being chosen so that they do not react covalently prior to reaction of the &bgr;-lactam ring with the target protease.Type: ApplicationFiled: January 21, 2003Publication date: August 14, 2003Inventors: Christopher Joseph Schofield, Rupert Charles Wilmouth
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Patent number: 6043278Abstract: The invention concerns perfluoro-lower-alkyl derivatives of amino acids. A new synthetic route is provided for preparing .alpha.-aminotrifluoromethylketones, by converting .alpha.-amino acids to oxazolidin-5-ones which are then reacted with Ruppert's Reagent. Fluorinated derivatives of amino acids and peptides are shown to have a new property of inhibiting or inactivating metallo-.beta.-lactamase enzymes, and are thus valuable components of antibacterial formulations. Certain of the trifluoromethyl derivatives of amino acids are new compounds per se.Type: GrantFiled: June 15, 1998Date of Patent: March 28, 2000Assignee: Isis Innovation LimitedInventors: Christopher Joseph Schofield, Magnus W Walter, Robert M Adlington, Jack E Baldwin, Jean-Marie Frere, Felici Antonio