Abstract: This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Abstract: The invention provides binding agents and assays for ghrelin signal peptide. The agents and assays are useful in methods for predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.

Abstract: This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.

Abstract: In a method and system of providing in-game assets for location-based actions, an indication of a performance of a location-based action by a player of a computer-implemented game is received. A virtual item is provided based on the receiving of the indication of the performance of the location-based action by the player of the computer-implemented game, the virtual item being usable within the computer-implemented game.

Abstract: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.

Abstract: This invention relates to the use of triazolone and triazolethione derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones and triazolethiones in the treatment of cancer.

Abstract: Described are methods, systems, and apparatuses, including computer program products, for biasing a musical performance input of a player of a rhythm-action game to a part in the game. In one aspect this is accomplished by providing, by a game platform, a history of a degree of matching between a prior music performance input data and a prior music data associated with a first part in a musical composition. Then, on a display, a plurality of target music data, each associated with a respective part in the musical composition, is displayed, with one of the plurality being associated with the first part. Music performance input data is received by the game platform via an input device, such as a microphone, and, based on the history, the received music performance input is assigned to the target music data of the plurality that is associated with the first part.

Abstract: The present disclosure generally relates to systems and methods for providing game-based incentives to users of online games as a reward for performing actions at physical locations.

Abstract: A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

Abstract: Described are methods, systems, and apparatuses, including computer program products, for displaying song lyrics and vocal cues in a rhythm-action game. In one aspect this is accomplished by displaying, on a display in communication with a game platform, a vocal cue. The vocal cue moves on the display in synchronization with a timing component of a musical composition towards a target marker. Lyrics are also displayed, but instead of moving with the movement of the vocal cue the lyrics are displayed in a fixed position. The lyrics maintain their position until the vocal cue has moved to a particular position with respect to the target marker.

Abstract: The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO.

Abstract: A device suitable for attachment to a milking platform at a “milking position” has a strippings viewing area and a light source, which is operable to illuminate in a suitable manner the strippings viewing area to enhance the visibility to an operator of any mastitis symptoms in use and/or to illuminate the udder to facilitate inspection or treatment. The light source may also be operable to give continuous or intermittent colour signals to the operator and the device might also include an alpha-numeric area. The device might form part of a leg separator and/or sprayer and/or milk hose support. A milking platform with such a device is also claimed.

Abstract: A filter element is disclosed. The filter element may include a first endcap. The filter element may also include a second endcap spaced from the first endcap along a central axis of the filter element. The filter element may also include an inner filter stage, which may include a first filter media that is disposed axially between the first and second endcaps and extends around the central axis of the filter element. Additionally, the filter element may include an outer filter stage, which may include a second filter media that is disposed axially between the first and second endcaps and extends around the inner filter stage. A radially inner portion of the second filter stage may adjoin a radially outer portion of the inner filter stage.

Abstract: Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or prevention of cardiovascular diseases, disorders, and conditions.

Abstract: The present disclosure generally relates to systems and methods for providing game-based incentives to users of online games as a reward for performing actions at physical locations.

Abstract: Systems and methods for providing game-based incentives to users of online games as a reward for performing actions at physical locations are provided.

Abstract: Disclosed herein, amongst other things, is a system for providing added safety for workers using rigging systems. In an embodiment, the invention includes a safety device for a roof rigging system including a rigger arm having a proximal end and a distal end; an attachment member disposed on the distal end of the rigger arm, the attachment member defining an aperture, the attachment member configured to engage a rigging line with the aperture; and a blocking member disposed on the distal end of the rigger arm, the blocking member configured to interface with the attachment member to prevent engagement of the attachment member with the rigging line by occluding the aperture when a counterweight is not attached to the roof rigging system.

Abstract: A system and method for providing dynamic pay-for-placement advertisements via graphics-enabled email that generates a display of advertisements when the email newsletter is opened so the advertisements displayed are based on rankings at the time the email is opened instead of when the email was generated and transmitted. In one embodiment, a graphical-content email having one or more embedded advertisement image references is provided to one or more email recipients. The advertisement image reference, in one embodiment, may include query string parameters indicating the context of the image reference and/or portion of the image reference (i.e., identifying the image reference as being part of a particular newsletter email), a position of the image reference in the email display, and the like. A URL reference also may be included with each advertisement image reference (.e.g., one URL for each advertisement portion of the image to be retrieved by the advertising image reference).

Abstract: An airspace risk mitigation system includes a plurality of airspace input sources, an airspace data fusion and sensor coordination system, a communications link, and a risk mitigation support system. The airspace input sources includes a radar for generating radar data for an airspace, and an Automatic Dependent Surveillance-Broadcast (ADS-B) receiver for generating additional data for the airspace. The airspace data fusion and sensor coordination system is configured to receive airspace data from the plurality of airspace input sources, correlating airspace data with new or known objects in the airspace, fusing airspace data into a common airspace data set, and generating target and system status information. The risk mitigation support system is configured to calculate a risk associated with aircraft operation in the airspace as a function of the target and system status information.

Abstract: Compounds of Formula I and methods for treating metabolic disorders are disclosed.