Abstract: A liquid heating appliance including a reservoir including a first and second chambers and a heating arrangement is provided. A mode valve is arranged to selectively allow liquid to flow between the first and second chambers. The appliance operates in a first mode in which the mode valve is closed and only liquid in the first chamber is heated and a second mode in which the mode valve is open and liquid in the first and second chambers is heated. A dispense outlet is moveable between a dispensing position and a non-dispensing position. The dispense outlet is mechanically coupled to the mode valve such that when the dispense outlet is moved into the dispense position, the mechanical coupling closes the mode valve and when the dispense outlet is moved into the non-dispensing position, the mechanical coupling opens the valve.

Abstract: A football shoulder pad assembly worn by a player is disclosed. The shoulder pad assembly includes a pair of curvilinear, continuous arch members worn over the shoulder of the player with the front arch portion extending over an extent of a chest and the rear arch portion extending over an extent of a back of the player. Each front arch portion including an upper connection slot with an elongated configuration and a lower connection aperture. The shoulder pad assembly also includes a front upper arch connector mechanism including a flexible upper strap and a pair of upper couplers slidingly received in said upper connection slots and a front lower arch connector mechanism including a flexible lower strap and a pair of lower couplers that pivots in said lower connection apertures. The rear arch portions including upper connection slots and lower connection apertures and coupled in a substantially similar manner.

Abstract: The use of a block copolymer of the following structure. Wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a polymer (or copolymer) of ethylene and polymer B is a polymer of monomers selected from vinyl acetate, C1-C9 acrylate esters, acrylic acid and mixtures thereof as an additive in polyethylene or polyethylene terephthalate to improve the adhesion between co-extruded layers of the polyethylene and the polyethylene terephthalate and laminated films derived from such use.

Abstract: A linear diblock copolymer of the general structure “Polymer A-linkage-Polymer B”, wherein Polymer A is essentially a nonpolar polymeric entity being a copolymer of propylene and ethylene, with propylene representing 51 to 99 weight percent of Polymer A; and Polymer B is a polymeric polar entity; and the use of said diblock copolymer to modify polymer bulk and interfacial properties in end applications as well as the intermediate material Polymer A-linkage useful in the manufacture of the diblock copolymer.

Abstract: A liquid heating appliance including a reservoir including a first and second chambers and a heating arrangement is provided. A mode valve is arranged to selectively allow liquid to flow between the first and second chambers. The appliance operates in a first mode in which the mode valve is closed and only liquid in the first chamber is heated and a second mode in which the mode valve is open and liquid in the first and second chambers is heated. A dispense outlet is moveable between a dispensing position and a non-dispensing position. The dispense outlet is mechanically coupled to the mode valve such that when the dispense outlet is moved into the dispense position, the mechanical coupling closes the mode valve and when the dispense outlet is moved into the non-dispensing position, the mechanical coupling opens the valve.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: The use of a block copolymer of the following structure. Wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a polymer (or copolymer) of ethylene and polymer B is a polymer of monomers selected from vinyl acetate, C1-C9 acrylate esters, acrylic acid and mixtures thereof as an additive in polyethylene or polyethylene terephthalate to improve the adhesion between co-extruded layers of the polyethylene and the polyethylene terephthalate and laminated films derived from such use.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: The invention relates to electrochemical wound dressings wherein potential damage to healthy cells and granulating tissue induced by hypochlorite and/or hypochlorous acid is reduced by enabling effective removal or build-up of substantial concentrations thereof through use of catalysts and/or scavenging/sacrificing agents. In another aspect, the present invention relates to the use of the latter materials in medical devices and articles.

Abstract: The invention relates to electrochemical wound dressings wherein potential damage to healthy cells and granulating tissue induced by hypochlorite and/or hypochlorous acid is reduced by enabling effective removal or build-up of substantial concentrations thereof through use of catalysts and/or scavenging/sacrificing agents. In another aspect, the present invention relates to the use of the latter materials in medical devices and articles.

Abstract: Materials having structure (1), wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or a C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a non-polar polymer formed by metallocene catalysis and polymer B is a polymer formed by radical catalysis of a polar monomer are used as polymer additives particularly to improve the compatibility of mixtures of polymers.

Abstract: Materials having structure (1), wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or a C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a non-polar polymer formed by metallocene catalysis and polymer B is a polymer formed by radical catalysis of a polar monomer are used as polymer additives particularly to improve the compatibility of mixtures of polymers.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: Methods, apparatuses, and computer readable media for detecting abnormalities in a characteristic of an eye using eye-imaging methods are presented. A plurality of images of the eye are received over time. Each image includes a plurality of pixels, which can be partitioned into blocks of pixels with varying sizes, called pixel partitions. A value is determined for each pixel partition, e.g., an average of the pixel values. A pixel partition set may be identified, which includes a pixel partition from each image, corresponding to a common region of a patient's eye. A regression model is computed for each pixel partition set using the values determined for each pixel partition. The regression model computes a rate of change of the retinal nerve fiber thickness at individual pixel partitions over time. An abnormality may be identified by comparing the rates of change of the model and the expected age-related rate of change.

Abstract: An effective dose of a pharmaceutically acceptable phenylbutyrate salt such as sodium phenylbutyrate applied to human ocular tissues or through injection or other means prevents ocular hypertension and treats glaucoma in humans, leading to a new medical therapy for lowering the intraocular pressure via a mechanism different from the existing glaucoma medications. This compound can be formulated in combination with topical or other forms of steroids in prevention and treatment of steroid induced ocular hypertension and glaucoma.

Abstract: Methods, apparatuses, and computer readable media for detecting abnormalities in a characteristic of an eye using eye-imaging methods are presented. A plurality of images of the eye are received over time. Each image includes a plurality of pixels, which can be partitioned into blocks of pixels with varying sizes, called pixel partitions. A value is determined for each pixel partition, e.g., an average of the pixel values. A pixel partition set may be identified, which includes a pixel partition from each image, corresponding to a common region of a patient's eye. A regression model is computed for each pixel partition set using the values determined for each pixel partition. The regression model computes a rate of change of the retinal nerve fiber thickness at individual pixel partitions over time. An abnormality may be identified by comparing the rates of change of the model and the expected age-related rate of change.

Abstract: An effective dose of a pharmaceutically acceptable phenylbutyrate salt such as sodium phenylbutyrate applied to human ocular tissues or through injection or other means prevents ocular hypertension and treats glaucoma in humans, leading to a new medical therapy for lowering the intraocular pressure via a mechanism different from the existing glaucoma medications. This compound can be formulated in combination with topical or other forms of steroids in prevention and treatment of steroid induced ocular hypertension and glaucoma.

Abstract: This invention relates to the stimulation of a specific combination of 5 acupuncture points including EX-HN5 (taiyang), BL59 (fuyang), BL2 (cuanzhu), GV20 (baihui), and LI4 (hegu) and its effectiveness in improving vision in the treatment of anisometropic amblyopia.

Abstract: The invention relates to a novel system for sports enthusiasts for displaying rival sports teams' logos by positioning the logo of a rival sports team low in the bowl of a toilet, urinal, sink, bath tub, or shower basin.