Abstract: A surgical instrument for use in operative cholangiography associated with a laparoscopic cholecystectomy. A catheter guide and clamp are combined in a single instrument manipulatable through a conventional trocar. The guide includes a straight elongate tube with an oblique exit opening for introducing a catheter tip through an incision in the cystic duct and laterally deflecting the inserted tip toward the common duct. The clamp longitudinally movable, and is operated from the proximal end of an actuator tube and stem to seal the duct around the catheter to prevent any fluid injected into the duct from leaking out through the incision.