Patents by Inventor Christopher Khoury
Christopher Khoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9987358Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.Type: GrantFiled: January 18, 2017Date of Patent: June 5, 2018Assignee: Duke UniversityInventors: Tuan Vo-Dinh, Hsiangkuo Yuan, Andrew Fales, Christopher Khoury
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Publication number: 20170151331Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.Type: ApplicationFiled: January 18, 2017Publication date: June 1, 2017Inventors: Tuan Vo-Dinh, Hsiangkuo Yuan, Andrew Fales, Christopher Khoury
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Patent number: 9561292Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.Type: GrantFiled: August 20, 2013Date of Patent: February 7, 2017Assignee: Duke UniversityInventors: Tuan Vo-Dinh, Hsiangkuo Yuan, Andrew Fales, Christopher Khoury
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Patent number: 7888107Abstract: A method and apparatus are provided for processing a nucleic acid. The apparatus includes a disposable self-contained processing module that contains the nucleic acid and substantially all of the fluids to effect a nanoparticle hybridization test, a pump coupled to the processing module, a valving system disposed between the pump and processing module and a control system coupled to the pump and valving system causing the processing fluids to interact with the nucleic acid to effect a sandwich hybridization test using nanoparticles.Type: GrantFiled: July 24, 2006Date of Patent: February 15, 2011Assignee: Nanosphere, Inc.Inventors: Tim Patno, Tom Westberg, Mark Weber, Benjamin Rush, Christopher Khoury, David Morrow, Janusz Ruszel, Christian Kronshage, William Cork
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Publication number: 20110008907Abstract: A method and apparatus are provided for processing a nucleic acid. The apparatus includes a disposable self-contained processing module that contains the nucleic acid and substantially all of the fluids to effect a nanoparticle hybridization test, a pump coupled to the processing module, a valving system disposed between the pump and processing module and a control system coupled to the pump and valving system causing the processing fluids to interact with the nucleic acid to effect a sandwich hybridization test using nanoparticles.Type: ApplicationFiled: July 24, 2006Publication date: January 13, 2011Inventors: Tim Patno, Tom Westberg, Mark Weber, Benjamin Rush, Christopher Khoury, David Morrow, Janusz Ruszel, Christian Kronshage, William Cork
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Publication number: 20080268458Abstract: A method is provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.Type: ApplicationFiled: July 8, 2008Publication date: October 30, 2008Applicant: Nanosphere, Inc.Inventors: Tim Patno, Jennifer Hollenstein, Christian Kronshage, Christopher Khoury, Mark Weber, Tom Westberg, William Cork
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Patent number: 7396677Abstract: A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.Type: GrantFiled: November 7, 2003Date of Patent: July 8, 2008Assignee: Nanosphere, Inc.Inventors: Tim Patno, Jennifer Hollenstein, Christian Kronshage, Christopher Khoury, Mark Weber, Tom Westberg, William Cork
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Publication number: 20050112583Abstract: A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.Type: ApplicationFiled: November 7, 2003Publication date: May 26, 2005Inventors: Tim Patno, Jennifer Hollenstein, Christian Kronshage, Christopher Khoury, Mark Weber, Tom Westberg, William Cork
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Publication number: 20040014106Abstract: A method for detecting a target analyte having a first binding site and a second binding site. A substrate is provided having at least a first and a second patterned conductor, the first conductor being separated from the second conductor. The arrangement of the patterned conductors forms at least two substantially non-conducting gaps. The method may also include contacting to the substrate capture probes that bind specifically to the first binding site of the target analyte and providing electrically conductive nanoparticles having bound thereto binding sites that bind specifically to the second binding site of the target analyte. Then, contacting the substrate and the electrically conductive nanoparticles with the target analyte under hybridizing conditions will bind the target analyte to the substrate and to the electrically conductive nanoparticles. The electrically conductive nanoparticles between the conductors can thus be electrically detected.Type: ApplicationFiled: May 14, 2003Publication date: January 22, 2004Applicant: Nanosphere, Inc.Inventors: Timothy Patno, Christopher Khoury
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Patent number: D790128Type: GrantFiled: February 9, 2016Date of Patent: June 20, 2017Inventors: John Christopher Khoury, Heather Kelly