Patents by Inventor Christopher Koradin

Christopher Koradin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREPARING ENANTIOMERICALLY ENRICHED 2-[2-(2-CHLOROTHIAZOL-5-YL)-2-HYDROXY-ETHYL]SULFANYL-6-HYDROXY-3-METHYL-5-PHENYL-PYRIMIDIN-4-ONE BY HYDROGENATION OF THE 2-OXO DERIVATIVE IN THE PRESENCE OF A CHIRAL TRANSITION METAL CATALYST
    Publication number: 20240262816
    Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one of the formula (I) by hydrogenation of 2-[2-(2-chlorothia-201-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one (1) in the presence of a chiral transition metal catalyst.
    Type: Application
    Filed: March 25, 2022
    Publication date: August 8, 2024
    Inventors: Martin John McLaughlin, Christopher Koradin, Rahul Kaduskar, Harish Shinde, Roland Goetz
  • METHOD FOR PREPARING AN ENANTIOMERICALLY ENRICHED FORM OF 2-[2-(2-CHLOROTHIAZOL-5-YL)-2-HYDROXY-ETHYL]SULFANYL-6-HYDROXY-3-METHYL-5-PHENYL-PYRIMIDIN-4-ONE
    Publication number: 20240116916
    Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof or enantiomerically enriched forms thereof, and to the use thereof as intermediate in the preparation of 2,3-dihydrothiazolo[3,2-a]pyrimidinium compounds, specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.
    Type: Application
    Filed: January 21, 2022
    Publication date: April 11, 2024
    Inventors: Martin John McLaughlin, Christopher Koradin, Rahul Kaduskar, Harish Shinde, Roland Gotez, Guillaume Michel Jacques Garivet
  • METHOD FOR PREPARING AN ENANTIOMERICALLY ENRICHED FORM OF 3-(2-CHLOROTHIAZOL-5-YL)-8-METHYL-7-OXO-6-PHENYL-2,3-DIHYDROTHIAZOLO[3,2-A]PYRIMIDIN-4-IUM-5-OLATE
    Publication number: 20240101575
    Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 28, 2024
    Inventors: Christopher Koradin, Martin John McLaughlin, Roland Goetz, Rahul Kaduskar, Harish Shinde
  • METHOD FOR PREPARING 2-[2-(2-CHLOROTHIAZOL-5-YL)-2-OXO-ETHYL]SULFANYL-6-HYDROXY-3-METHYL-5-PHENYL-PYRIMIDIN-4-ONE
    Publication number: 20240101547
    Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 28, 2024
    Inventors: Christopher Koradin, Martin John McLaughlin, Roland Goetz, Rahul Kaduskar, Harish Shinde, Guillaume Michel Jacques Garivet
  • PREPARATION OF 2-CHLORO-1-(2-CHLOROTHIAZOL-5-YL)ETHANONE
    Publication number: 20240051929
    Abstract: The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.
    Type: Application
    Filed: September 28, 2020
    Publication date: February 15, 2024
    Inventors: Harish Shinde, Rahul Kaduskar, Christopher Koradin, Martin John McLaughlin, Roland Goetz, Sunil Khamkar
  • METHOD FOR PREPARING AN ENANTIOMERICALLY ENRICHED FORM OF 3-(2-CHLOROTHIAZOL-5-YL)-8-METHYL-7-OXO-6-PHENYL-2,3-DIHYDROTHIAZOLO[3,2-A]PYRIMIDIN-4-IUM-5-OLATE
    Publication number: 20230416273
    Abstract: The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.
    Type: Application
    Filed: January 21, 2022
    Publication date: December 28, 2023
    Inventors: Christopher Koradin, Martin John McLaughlin, Harish Shinde, Rahul Kaduskar, Ronald Goetz, Guillaaume Michel Jaques Garivet
  • PREPARATION OF AROMATIC CARBOXYAMIDES BY A PALLADIUM-CATALYZED CARBONYLATION REACTION
    Publication number: 20230339847
    Abstract: The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by a palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of 1,5,7-triazabi-cyclo[4.4.0]dec-5-ene. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.
    Type: Application
    Filed: April 19, 2021
    Publication date: October 26, 2023
    Inventors: Mathias Schelwies, Florian Vogt, Christopher Koradin, Rocco Paciello, Roland Goetz
  • PREPARATION OF 2-CHLORO-1-(2-CHLOROTHIAZOL-5-YL)ETHANONE
    Publication number: 20230322693
    Abstract: The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.
    Type: Application
    Filed: September 28, 2021
    Publication date: October 12, 2023
    Inventors: Christopher Koradin, Harish Shinde, Martin John McLaughlin, Rahul Kaduskar, Philipp M. Staehle, Roland Goetz, Sunil Khamkar
  • PREPARATION OF AROMATIC CARBOXYAMIDES BY PALLADIUM-CATALYZED CARBONYLATION REACTION
    Publication number: 20230167050
    Abstract: Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction The present invention relates to a process for the preparation of aromatic carboxyamides of formula I, which can be obtained by palladium-catalyzed carbonylation reaction of aromatic chlorides of formula II, amines of formula III and carbon monoxide in the presence of a base. The invention further relates to a process for the preparation of aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are known for controlling phytopathogenic fungi.
    Type: Application
    Filed: April 19, 2021
    Publication date: June 1, 2023
    Inventors: Mathias Schelwies, Christopher Koradin, Rocco Paciello, Roland Goetz, Florian Vogt
  • PREPARATION OF SUBSTITUTED 3-ARYL-5-TRIFLUOROMETHYL-1,2,4-OXADIAZOLES
    Publication number: 20230145982
    Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula I, which can be obtained through reaction of amidoxime compounds of formula II with a haloacetic ester in the presence of a solvent and a base.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 11, 2023
    Inventors: Florian Vogt, Kailaskumar Borate, Bernd Wolf, Christopher Koradin, Joachim Gebhardt, Roland Goetz, Harish Shinde
  • PREPARATION OF SUBSTITUTED 3-ARYL-5-TRIFLUOROMETHYL-1,2,4-OXADIAZOLES
    Publication number: 20230066401
    Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.
    Type: Application
    Filed: February 1, 2021
    Publication date: March 2, 2023
    Inventors: Florian Vogt, Kailaskumar Borate, Bernd Wolf, Christopher Koradin, Roland Goetz, Harish Shinde
  • PREPARATION OF SUBSTITUTED AROMATIC CARBOXAMIDES
    Publication number: 20230028964
    Abstract: The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process is conducted in the absence of an auxiliary base in a carboxylic acid ester as solvent.
    Type: Application
    Filed: November 25, 2020
    Publication date: January 26, 2023
    Inventors: Kailaskumar Borate, Bernd Wolf, Florian Vogt, Christopher Koradin, Roland Goetz, Harish Shinde
  • METHOD FOR PRODUCTION OF 4-CYANO BENZOIC ACID OR SALTS THEREOF
    Publication number: 20220017931
    Abstract: Described herein are methods for the production of 4-cyano benzoic acid or salts thereof from terephthalonitrile using nitrilase as catalyst. Also described herein are compositions including 4-cyano benzoic acid.
    Type: Application
    Filed: January 20, 2020
    Publication date: January 20, 2022
    Inventors: Diego Ghislieri, Christian Willrodt, Christopher Koradin, Stefan Seemayer, Doreen Schachtschabel, Kai-Uwe Baldenius, Roland Goetz
  • Process for preparing optically active 2,3-dihydrothiazolo[3,2-A]pyrimidin-4-ium compounds
    Patent number: 11124528
    Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: September 21, 2021
    Assignee: BASF SE
    Inventors: Harish Shinde, Christopher Koradin, Joachim Dickhaut, Roland Goetz, Michael Rack, Eric George Klauber, Sukunath Narayanan, Dhanyakumar Raut
  • Process for preparing chiral 2,3-dihydrothiazolo[3,2-A] pyrimidin-4-ium compounds
    Patent number: 11034703
    Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: June 15, 2021
    Assignee: BASF SE
    Inventors: Harish Shinde, Christopher Koradin, Joachim Dickhaut, Roland Goetz, Eric George Klauber, Sukunath Narayanan, Dhanyakumar Raut
  • Preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles
    Patent number: 11021452
    Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.
    Type: Grant
    Filed: July 21, 2018
    Date of Patent: June 1, 2021
    Assignee: BASF SE
    Inventors: Christopher Koradin, Wassilios Grammenos, Michael Rack, Kailaskumar Borate, Roland Goetz
  • PROCESS FOR PREPARING CHIRAL 2,3-DIHYDROTHIAZOLO[3,2-A]PYRIMIDIN-4-IUM COMPOUNDS
    Publication number: 20210087207
    Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.
    Type: Application
    Filed: May 2, 2018
    Publication date: March 25, 2021
    Inventors: Harish SHINDE, Christopher KORADIN, Joachim DICKHAUT, Roland GOETZ, Eric George KLAUBER, Sukunath NARAYANAN, Dhanyakumar RAUT
  • PREPARATION OF SUBSTITUTED 3-ARYL-5-TRIFLUOROMETHYL-1,2,4-OXADIAZOLES
    Publication number: 20200231556
    Abstract: The present invention relates to a process for the preparation of 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles, which are useful as fungicidal compounds or as intermediates for the synthesis of fungicidal oxaciazole compounds, using trifluoroacetyl halides.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 23, 2020
    Inventors: Wassilios GRAMMENOS, Michael RACK, Violeta TERTERYAN-SEISER, Christopher KORADIN
  • Preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles
    Publication number: 20200157064
    Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.
    Type: Application
    Filed: July 21, 2018
    Publication date: May 21, 2020
    Inventors: Christopher Koradin, Wassilios Grammenos, Michael Rack, Kailaskumar Borate, Roland Goetz
  • Process for Preparing Optically Active 2,3-Dihydrothiazolo[3,2-A]pyrimidin-4-ium Compounds
    Publication number: 20200055872
    Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.
    Type: Application
    Filed: April 25, 2018
    Publication date: February 20, 2020
    Inventors: Harish SHINDE, Christopher KORADIN, Joachim DICKHAUT, Roland GOETZ, Michael RACK, Eric George KLAUBER, Sukunath NARAYANAN, Dhanyakumar RAUT