Abstract: A system (1) for monitoring critical pharmaceutical operations comprises an enclosure (10) defining an interior space (100), at least one camera (11) installed so as to record image frames (F) of the interior space (100), and a controller (12), wherein the controller (12) is configured to: receive the image frames (F) recorded by the at least one camera (11), analyse the image frames (F) to detect an event captured by one or more of the image frames (F), using a first model perform a classification of an intervention captured by the one or more of the image frames (F) using a second model (ML 2), the second model (ML 2) being trained with image frames of interventions assigned to at least two different classes, and provide a notification (N) indicating one of the at least two different classes based on the classification.

Abstract: The present disclosure relates to chimeric ABC transporter proteins and methods of screening for molecules that bind to the periplasmic, extracellular, and/or luminal face of an ABC transporter protein using the chimeric ABC transporters. For example, in some embodiments, screening methods involve providing a chimeric ABC transporter in which one or more regions of the periplasmic, extracellular, and/or luminal face of the ABC transporter are substituted with one or more equivalent regions of the periplasmic, extracellular, and/or luminal face of a different ABC transporter and selecting for molecules that bind to the ABC transporter but do not bind to the chimeric ABC transporter. The disclosure also relates to molecules that bind to the periplasmic, extracellular, and/or luminal face of an ABC transporter protein, for example, identified in such screens.

Abstract: A system for validating a system for monitoring pharmaceutical operations includes at least one controller configured to perform a classification of an intervention captured by one or more image frames using a classification model, the classification model being trained with image frames of interventions assigned to at least two different classes. The at least one controller is also configured to assign a value to an individual feature of a feature set associated with the classification, the value corresponding to a contribution of the individual feature to the classification. In addition, the at least one controller is configured to generate a graphical representation of the values for the features contributing to the classification of the interventions.

Abstract: The present invention relates to a highly efficient method for producing oil-in-water emulsions, preferably for parenteral administration, which method is characterized in that large parts of the water phase are added only after the energy-intensive homogenization of the pre-emulsion, i.e. an emulsion having low water content is first produced and said emulsion is subsequently “diluted”.