Patents by Inventor Christopher Krause
Christopher Krause has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12480877Abstract: A method for detecting a potential presence of a fluorescence pattern type on an organ section via immunofluorescence microscopy and digital image processing, the method comprising: providing an organ section on a slide, incubating the section with a liquid patient sample potentially including primary antibodies and secondary antibodies labelled with a fluorescent dye, acquiring a fluorescence image of the organ section, determining, by segmentation of the fluorescence image via a first neural network, a sub-area of the fluorescence image relevant to formation of the fluorescence pattern type, determining, via a second neural network, the measure of confidence indicating an actual presence of the fluorescence pattern type, determining, validity information indicating a degree of a validity of the measure of confidence, and outputting the measure of confidence of the actual presence of the fluorescence pattern type and of the validity information.Type: GrantFiled: December 21, 2021Date of Patent: November 25, 2025Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
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Publication number: 20250347819Abstract: Fluid detection systems and methods using the same are disclosed. In embodiments the fluid detection systems include a sensor module and an electronics module. The sensor module includes a sensor housing that includes a liquid flow path and a sensor element disposed around at least part of the liquid flow path. The sensor element can detect a capacitance of the liquid flow path and provide a sensor signal to a controller in the electronics module. The electronics module can determine a detected capacitance in the liquid flow path based at least in part on the sensor signal, and can determine whether a wet event has occurred based on a comparison of the detected capacitance to a threshold capacitance. Methods using the fluid detection systems and fluid supply systems including the fluid detection systems are also disclosed.Type: ApplicationFiled: July 22, 2025Publication date: November 13, 2025Inventors: STEVEN CASTRIGNO, JAMES ERHARDT, CHRISTOPHER KRAUSE
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Publication number: 20250308020Abstract: Proposed is a method for determining a focusing measure of a microscopic image, the microscopic image representing an image of a biological cellular substrate, the method comprising: providing the microscopic image, determining a gradient image on the basis of the microscopic image, processing image information from the gradient image and image information from the microscopic image by means of a neural network to determine the focusing measure, the focusing measure indicating quality of focusing in the microscopic image in relation to a cellular substrate plane of the cellular substrate.Type: ApplicationFiled: March 25, 2025Publication date: October 2, 2025Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens HOCKE, Jens KRAUTH, Stefan GERLACH, Christopher KRAUSE, Roland HAASE, Melanie HAHN, Jörn VOIGT
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Patent number: 12392723Abstract: There is proposed a method for detecting a presence of a fluorescence pattern type on an organ segment via immunofluorescence microscopy and digital image processing. The steps comprise: provision of the organ segment, incubation of the organ segment with a liquid patient sample, incubation of the organ segment with secondary antibodies which have been labelled with a fluorescent dye, acquisition of a fluorescence image of the organ segment in a colour channel corresponding to the fluorescent dye, and provision of the fluorescence image to a neural network. What takes place by means of the neural network is simultaneous determination of segmentation information through segmentation of the fluorescence image and, furthermore, of a measure of confidence indicating an actual presence of the fluorescence pattern type.Type: GrantFiled: August 25, 2022Date of Patent: August 19, 2025Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Jens Krauth, Christian Marzahl, Christopher Krause, Jens Hocke, Maick Danckwardt, Melanie Hahn, Jörn Voigt
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Patent number: 12392919Abstract: Fluid detection systems and methods using the same are disclosed. In embodiments the fluid detection systems include a sensor module and an electronics module. The sensor module includes a sensor housing that includes a liquid flow path and a sensor element disposed around at least part of the liquid flow path. The sensor element can detect a capacitance of the liquid flow path and provide a sensor signal to a controller in the electronics module. The electronics module can determine a detected capacitance in the liquid flow path based at least in part on the sensor signal, and can determine whether a wet event has occurred based on a comparison of the detected capacitance to a threshold capacitance. Methods using the fluid detection systems and fluid supply systems including the fluid detection systems are also disclosed.Type: GrantFiled: December 8, 2021Date of Patent: August 19, 2025Assignee: WATTS REGULATOR CO.Inventors: Steven Castrigno, James Erhardt, Christopher Krause
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Patent number: 12372532Abstract: There is proposed a method for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid using Crithidia luciliae cells by means of fluorescence microscopy, including the steps of: provision of a substrate which has multiple Crithidia luciliae cells, incubation of the substrate with the patient sample which potentially has the autoantibodies, incubation of the substrate with secondary antibodies which have each been labelled with a preferably green fluorescent dye, acquisition of a fluorescence image of the substrate, identification by means of a first pretrained convolutional neural network of respective sub-images in the one fluorescence image that each represent a Crithidia luciliae cell, furthermore respective processing of at least one subset of the respective sub-images by means of a second pretrained convolutional neural network for determining respective binding measures which indicate a respective extent of a binding of autoantibodies in a respective kinetopType: GrantFiled: September 17, 2021Date of Patent: July 29, 2025Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Jens Krauth, Christian Marzahl, Christopher Krause, Maick Danckwardt, Melanie Hahn, Jörn Voigt
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Patent number: 12209965Abstract: A method and apparatus are provided for detecting respective potential presences of respective different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells (HEp cells), wherein the fluorescence pattern types include different antinuclear antibody fluorescence pattern types. A method is also provided for detecting potential presences of different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells by means of digital image processing, as well as a computing unit, a data network device, a computer program product and a data carrier signal therefor.Type: GrantFiled: January 19, 2022Date of Patent: January 28, 2025Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christopher Krause, Jens Krauth, Stefan Gerlach, Christian Marzahl, Melanie Hahn, Joern Voigt
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Publication number: 20240119589Abstract: A method is proposed for detecting a presence of a fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially comprises primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining respective items of location information, which indicate respective locations of respective relevant subsections of the cell substrate in the fluorescence image, and determining respective first partial confidence measures of respective presences of the fluorescence pattern on the respective subsections by means of a first neural network on the basis of the overall fluorescence image, extracting respective image subsections, which correspond to the respective subsections of the cell substrate, from the fluorescence image on the basis of theType: ApplicationFiled: September 22, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens KRAUTH, Jens HOCKE, Stefan GERLACH, Christopher KRAUSE, Melanie HAHN, Jörn VOIGT
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Publication number: 20240118209Abstract: A method is proposed for detecting at least one fluorescence pattern on an immunofluorescence image of a biological cell substrate, comprising the following steps: incubating the cell substrate with a liquid patient sample, which potentially includes primary antibodies, and furthermore with secondary antibodies, which are marked using a fluorescence stain, irradiating the cell substrate using excitation radiation and capturing the immunofluorescence image, determining segmentation information comprising at least one first and one second segmentation area, wherein the segmentation areas each represent a respective cell substrate area, via segmentation of the immunofluorescence image using a first neural network, determining a boundary area, which represents a transition from the first cell substrate area towards the second cell substrate area in the fluorescence image, on the basis of the segmentation information, selecting multiple partial images from the immunofluorescence image along the boundary area, deteType: ApplicationFiled: September 29, 2023Publication date: April 11, 2024Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Hocke, Jens Krauth, Stefan Gerlach, Christopher Krause, Melanie Hahn, Jörn Voigt, Enno SCHMIDT, Nina VAN BEEK
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Patent number: 11898625Abstract: A stator assembly for a torque converter includes a body, a one-way clutch, and a washer. The body is rotatable about an axis and has a cavity defined by an axial wall radially spaced from the axis and a radial wall extending radially inward from the axial wall. The one-way clutch is disposed in the cavity. The washer includes a thrust surface, a supporting surface, and an axial retention feature. The thrust surface faces away from the cavity. The supporting surface directly contacts the one-way clutch. The axial retention element is configured to connect to the axial wall of the body.Type: GrantFiled: January 12, 2023Date of Patent: February 13, 2024Assignee: Schaeffler Technologies AG & Co. KGInventors: Alexander Reimchen, Christopher Krause
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Publication number: 20240036226Abstract: Fluid detection systems and methods using the same are disclosed. In embodiments the fluid detection systems include a sensor module and an electronics module. The sensor module includes a sensor housing that includes a liquid flow path and a sensor element disposed around at least part of the liquid flow path. The sensor element can detect a capacitance of the liquid flow path and provide a sensor signal to a controller in the electronics module. The electronics module can determine a detected capacitance in the liquid flow path based at least in part on the sensor signal, and can determine whether a wet event has occurred based on a comparison of the detected capacitance to a threshold capacitance. Methods using the fluid detection systems and fluid supply systems including the fluid detection systems are also disclosed.Type: ApplicationFiled: December 8, 2021Publication date: February 1, 2024Applicant: WATTS REGULATOR CO.Inventors: STEVEN CASTRIGNO, JAMES ERHARDT, CHRISTOPHER KRAUSE
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Publication number: 20230071078Abstract: There is proposed a method for detecting a presence of a fluorescence pattern type on an organ segment via immunofluorescence microscopy and digital image processing. The steps comprise: provision of the organ segment, incubation of the organ segment with a liquid patient sample, incubation of the organ segment with secondary antibodies which have been labelled with a fluorescent dye, acquisition of a fluorescence image of the organ segment in a colour channel corresponding to the fluorescent dye, and provision of the fluorescence image to a neural network. What takes place by means of the neural network is simultaneous determination of segmentation information through segmentation of the fluorescence image and, furthermore, of a measure of confidence indicating an actual presence of the fluorescence pattern type.Type: ApplicationFiled: August 25, 2022Publication date: March 9, 2023Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan GERLACH, Jens KRAUTH, Christian MARZAHL, Christopher KRAUSE, Jens HOCKE, Maick DANCKWARDT, Melanie HAHN, Jörn VOIGT
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Publication number: 20220404283Abstract: A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed. An organ section is provided on a slide and the section is incubated with a liquid patient sample which potentially includes primary antibodies and with secondary antibodies which have been labelled with a fluorescent dye. A fluorescence image of the organ section is acquired. A determination is made, by segmentation of the fluorescence image by means of a first neural network, of a sub-area of the fluorescence image that is relevant to formation of the fluorescence pattern type. A determination is made, on the basis of the fluorescence image by means of a second neural network, of the measure of confidence that indicates an actual presence of the fluorescence pattern type.Type: ApplicationFiled: December 21, 2021Publication date: December 22, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
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Publication number: 20220228989Abstract: A method and apparatus are provided for detecting respective potential presences of respective different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells (HEp cells), wherein the fluorescence pattern types include different antinuclear antibody fluorescence pattern types. A method is also provided for detecting potential presences of different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells by means of digital image processing, as well as a computing unit, a data network device, a computer program product and a data carrier signal therefor.Type: ApplicationFiled: January 19, 2022Publication date: July 21, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Christopher Krause, Jens Krauth, Stefan Gerlach, Christian Marzahl, Melanie Hahn, Joern Voigt
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Publication number: 20220196553Abstract: A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed. An organ section is provided on a slide and the section is incubated with a liquid patient sample which potentially includes primary antibodies and with secondary antibodies which have been labelled with a fluorescent dye. A fluorescence image of the organ section is acquired. A determination is made, by segmentation of the fluorescence image by means of a first neural network, of a sub-area of the fluorescence image that is relevant to formation of the fluorescence pattern type. A determination is made, on the basis of the fluorescence image by means of a second neural network, of the measure of confidence that indicates an actual presence of the fluorescence pattern type.Type: ApplicationFiled: December 21, 2021Publication date: June 23, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
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Patent number: 11367187Abstract: A method is for detecting respective potential presence of respective different antinuclear antibody fluorescence pattern types on a biological cell substrate including human epithelioma cells, including: acquiring a first image which represents staining of the cell substrate by a first fluorescent dye, and acquiring a second image which represents staining of the cell substrate by a second fluorescent dye, detecting, on the basis of the first image, respective image segments which in each case represent at least one mitotic cell, selecting, on the basis of the detected image segments, subimages of the first image and subimages corresponding thereto of the second image and detecting, on the basis of the selected subimages of the first image and of the selected subimages of the second image, respective actual presence of respective cellular fluorescence pattern types by means of a convolutional neural network.Type: GrantFiled: July 2, 2020Date of Patent: June 21, 2022Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens Krauth, Christopher Krause, Joern Voigt, Melanie Hahn, Christian Marzahl, Stefan Gerlach
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Publication number: 20220082567Abstract: There is proposed a method for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid using Crithidia luciliae cells by means of fluorescence microscopy, including the steps of: provision of a substrate which has multiple Crithidia luciliae cells, incubation of the substrate with the patient sample which potentially has the autoantibodies, incubation of the substrate with secondary antibodies which have each been labelled with a preferably green fluorescent dye, acquisition of a fluorescence image of the substrate, identification by means of a first pretrained convolutional neural network of respective sub-images in the one fluorescence image that each represent a Crithidia luciliae cell, furthermore respective processing of at least one subset of the respective sub-images by means of a second pretrained convolutional neural network for determining respective binding measures which indicate a respective extent of a binding of autoantibodies in a respective kinetopType: ApplicationFiled: September 17, 2021Publication date: March 17, 2022Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Stefan Gerlach, Jens Krauth, Christian Marzahl, Christopher Krause, Maick Danckwardt, Melanie Hahn, Jörn Voigt
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Patent number: 11181176Abstract: A turbine assembly includes a turbine shell, turbine hub, and a thrust washer. The turbine hub is coupled to the turbine shell via a fastener. The thrust washer is disposed on the turbine hub and includes at least one tab configured to contact the fastener. The fastener axially and radially retains the thrust washer on the turbine hub.Type: GrantFiled: February 19, 2020Date of Patent: November 23, 2021Assignee: Schaeffler Technologies AG & Co. KGInventors: Scott Angel, Christopher Krause
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Publication number: 20210019883Abstract: A method is for detecting respective potential presence of respective different antinuclear antibody fluorescence pattern types on a biological cell substrate including human epithelioma cells, including: acquiring a first image which represents staining of the cell substrate by a first fluorescent dye, and acquiring a second image which represents staining of the cell substrate by a second fluorescent dye, detecting, on the basis of the first image, respective image segments which in each case represent at least one mitotic cell, selecting, on the basis of the detected image segments, subimages of the first image and subimages corresponding thereto of the second image and detecting, on the basis of the selected subimages of the first image and of the selected subimages of the second image, respective actual presence of respective cellular fluorescence pattern types by means of a convolutional neural network.Type: ApplicationFiled: July 2, 2020Publication date: January 21, 2021Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Jens KRAUTH, Christopher Krause, Joern Voigt, Melanie Hahn, Christian Marzahl, Stefan Gerlach
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Publication number: 20200263774Abstract: A turbine assembly includes a turbine shell, turbine hub, and a thrust washer. The turbine hub is coupled to the turbine shell via a fastener. The thrust washer is disposed on the turbine hub and includes at least one tab configured to contact the fastener. The fastener axially and radially retains the thrust washer on the turbine hub.Type: ApplicationFiled: February 19, 2020Publication date: August 20, 2020Applicant: Schaeffler Technologies AG & Co. KGInventors: Scott Angel, Christopher Krause