Abstract: A needle injection system (“NIS”) comprised of a unique compartmental arrangement. More specifically, an NIS that utilizes two separate energy storage units, wherein one energy storage unit drives the needle from a first position inside a housing to a second position outside of the housing, and the second energy storage unit applies pressure to the medicament storage container in order expel the medication through the needle. A fluid communication channel is located between the medicament storage container and needle. The fluid communication channel contains a seal that prevents fluid flow to, and fluid communication with, the needle until the device is intentionally activated. The seal can be a geometrical seal or a frangible seal capable of being punctured. The geometrical seal can be comprised of a system of O-rings and a sliding alignment hole, which, when aligned, completes the fluid communication. The frangible seal can face perpendicular to the needle.