Abstract: Medical devices for cinching and cutting one or more suture, and methods for making and using such devices are disclosed. An example medical device may include a shaft, a sleeve attached to the shaft, cutter slidable within the sleeve, a cinch sleeve releasably coupled to the sleeve, and a cinch member. An elongated inner shaft may extend through and be longitudinally movable within the elongated shaft, sleeve, cutter, cinch sleeve, and cinch member. The inner shaft may be actuated to cinch and cut one or more suture disposed within the device.

Abstract: A manometry system includes a manometric catheter configured to sense pressure within a gastrointestinal tract, a wireless assembly configured for transmitting/receiving signals to/from the catheter, and a base unit configured to calibrate the catheter prior to usage thereof and to store and charge a wireless electronics module of the wireless assembly.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, apparatuses, and systems are described for minimizing various leakage effects of multi-zone ablation devices. Apparatuses may include an ablation device for treatment of tissue including an ablation structure with a plurality of bipolar electrode zones. Each of the zones may include an in-zone channel pair comprising a positive channel and a negative channel. The ablation structure may be configured such that, for any adjacent electrode zone pair comprising a first electrode zone and a second electrode zone adjacent to the first electrode zone, the positive channel of the first electrode zone is electrically distinct from the positive channel of the second electrode zone, and the negative channel of the first electrode zone is electrically distinct from the negative channel of the second electrode zone. Moreover, the ablation structure may be arranged such that a total number of electrically distinct channels that is less than twice a total number of the plurality of electrode zones.

Abstract: Methods, apparatuses, and systems are described for minimizing various leakage effects of multi-zone ablation devices. Apparatuses may include an ablation device for treatment of tissue including an ablation structure with a plurality of bipolar electrode zones. Each of the zones may include an in-zone channel pair comprising a positive channel and a negative channel. The ablation structure may be configured such that, for any adjacent electrode zone pair comprising a first electrode zone and a second electrode zone adjacent to the first electrode zone, the positive channel of the first electrode zone is electrically distinct from the positive channel of the second electrode zone, and the negative channel of the first electrode zone is electrically distinct from the negative channel of the second electrode zone. Moreover, the ablation structure may be arranged such that a total number of electrically distinct channels that is less than twice a total number of the plurality of electrode zones.

Abstract: Methods, apparatuses, and systems are described for minimizing various leakage effects of multi-zone ablation devices. Apparatuses may include an ablation device for treatment of tissue including an ablation structure with a plurality of bipolar electrode zones. Each of the zones may include an in-zone channel pair comprising a positive channel and a negative channel. The ablation structure may be configured such that, for any adjacent electrode zone pair comprising a first electrode zone and a second electrode zone adjacent to the first electrode zone, the positive channel of the first electrode zone is electrically distinct from the positive channel of the second electrode zone, and the negative channel of the first electrode zone is electrically distinct from the negative channel of the second electrode zone. Moreover, the ablation structure may be arranged such that a total number of electrically distinct channels that is less than twice a total number of the plurality of electrode zones.

Abstract: Methods, apparatuses and systems are described for preventing the over-tightening of a furled ablation structure support around an expandable member. An ablation device for treatment of tissue in body lumens with varying sizes is disclosed. The ablation device may include a catheter, an expansion member coupled with a distal portion of the catheter, and an ablation structure support configured to at least partially unfurl or furl around the expansion member as the expansion member expands or contracts. The ablation device may further include a spacer coupled with the catheter and configured to limit a minimum diameter of the ablation structure support when the expansion member is completely contracted.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, apparatuses, and systems are described for accessing a body lumen for subsequent treatment thereof. Systems include a cannula configured to penetrate a wall of a body lumen and to passively transition to a nonlinear shape within the body lumen as an elongate member is withdrawn from the distal section of the cannula. Other embodiments include a handle, a cannula removably disposed within a lumen of the handle, and a penetration member sized to advance through a lumen of the cannula, the cannula configured to passively transition to a nonlinear shape as the penetration member is withdrawn from a distal section of the cannula, and a cannula hub configured to selectively engage with a proximal end of the handle to selectively lock rotational movement of the cannula with respect to the handle.

Abstract: Methods, apparatuses and systems are described for preventing the over-tightening of a furled ablation structure support around an expandable member. An ablation device for treatment of tissue in body lumens with varying sizes is disclosed. The ablation device may include a catheter, an expansion member coupled with a distal portion of the catheter, and an ablation structure support configured to at least partially unfurl or furl around the expansion member as the expansion member expands or contracts. The ablation device may further include a spacer coupled with the catheter and configured to limit a minimum diameter of the ablation structure support when the expansion member is completely contracted.

Abstract: Methods, apparatuses, and systems are described for minimizing various leakage effects of multi-zone ablation devices. Apparatuses may include an ablation device for treatment of tissue including an ablation structure with a plurality of bipolar electrode zones. Each of the zones may include an in-zone channel pair comprising a positive channel and a negative channel. The ablation structure may be configured such that, for any adjacent electrode zone pair comprising a first electrode zone and a second electrode zone adjacent to the first electrode zone, the positive channel of the first electrode zone is electrically distinct from the positive channel of the second electrode zone, and the negative channel of the first electrode zone is electrically distinct from the negative channel of the second electrode zone. Moreover, the ablation structure may be arranged such that a total number of electrically distinct channels that is less than twice a total number of the plurality of electrode zones.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a support shaft, an expansion member coupled with a distal portion of the support shaft, and an ablation structure wrapped around the expansion member less than a circumference of the expansion member configured to engage the body lumens with varying sizes. The ablation structure may include multiple separately wired or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. The expansion member may include a single highly-compliant balloon, a single non-compliant balloon, multiple non-compliant balloons, or a multi-chambered non-compliant balloon.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.

Abstract: Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter.