Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: A hands-free adapter for a telephone is disclosed. The hands-free adapter includes a housing, a speaker and a microphone that may be electrically coupled to a telephone. The hands-free adapter couples to a cigarette lighter receptacle of a vehicle. This provides power to operate the speaker and the microphone. In addition, power is coupled to the telephone for operating the telephone and charging the telephones batteries. The hands-free adapter also includes an articulating cable for positioning the speaker and the microphone near a user. The microphone is disposed within a boom which is pivotally coupled to the housing such that the boom may be moved from a retracted position to a fully extended position. The microphone is automatically activated as it is moved out of the retracted position and is automatically deactivated as it is moved back into the retracted position.

Abstract: A cradle for a telephone is disclosed. The telephone cradle includes a latch bar and a spring mechanism and a latching mechanism. The latch bar pivots so as to capture a telephone when the telephone is inserted into the cradle, thereby securely holding the telephone in the cradle. A user then may release the telephone by pressing on the top surface of the latch bar. As the user presses on the latch bar a latching mechanism is released and the latch bar moves into the released position, thereby moving the telephone so that it is easily grasped by a user.

Abstract: A speaker and microphone are provided on and supported by an articulating extension. The extension comprises a cigarette lighter adapter which is plugged into a cigarette lighter to provide power for the speaker and microphone. The speaker and microphone are connected to a wireless telephone such that the speaker and microphone can be used to place a call with the telephone in a hands free manner. The extension articulates to optimally orient the speaker and microphone with respect to the user.