Abstract: The present disclosure provides systems, devices, methods, and computer-readable media for determining a social determinants of health (SDoH) score. A method can include receiving first data of three or more data types, each data type corresponding to an SDoH domain including economic stability, education, social and community context, health and health care, and neighborhood and built environment, the first data related to a specified geographic region, performing a principal component analysis (PCA) on the received first data to determine respective contribution values for each domain, the contribution values indicating a relative amount of variation the domain contributes to the SDoH score, receiving second data of the three or more data types, the second data related to first sub-geographical region within the specified geographic region, and determining the SDoH score for the first sub-geographical region based on the received second data and the corresponding contribution values.