Patents by Inventor Christopher L. VanDeusen

Christopher L. VanDeusen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EIF4E INHIBITORS AND USES THEREOF
    Publication number: 20230399322
    Abstract: The present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
    Type: Application
    Filed: June 15, 2023
    Publication date: December 14, 2023
    Inventors: Christopher L. VANDEUSEN, Alan E. Walts, Yat Sun Or
  • EIF4E inhibitors and uses thereof
    Patent number: 11753403
    Abstract: The present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: September 12, 2023
    Assignee: PIC Therapeutics, Inc.
    Inventors: Christopher L. Vandeusen, Alan E. Walts, Yat Sun Or
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20230190747
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: November 22, 2022
    Publication date: June 22, 2023
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, Andrea HILLEGASS, George LEE
  • EIF4E INHIBITORS AND USES THEREOF
    Publication number: 20230150997
    Abstract: The present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
    Type: Application
    Filed: August 25, 2022
    Publication date: May 18, 2023
    Inventor: Christopher L. VANDEUSEN
  • EIF4E INHIBITORS AND USES THEREOF
    Publication number: 20230134932
    Abstract: The present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
    Type: Application
    Filed: August 25, 2022
    Publication date: May 4, 2023
    Inventor: Christopher L. VANDEUSEN
  • EIF4E INHIBITORS AND USES THEREOF
    Publication number: 20220356178
    Abstract: The present invention provides compounds inhibiting eIF4E activity, and compositions and methods of using thereof.
    Type: Application
    Filed: March 3, 2021
    Publication date: November 10, 2022
    Inventors: Christopher L. VANDEUSEN, Alan E. WALTS, Yat Sun OR
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20210330671
    Abstract: This invention is directed to a compound of formula (1): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: April 9, 2021
    Publication date: October 28, 2021
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20200383982
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: December 23, 2019
    Publication date: December 10, 2020
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20190262338
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related to macular degeneration (AMD).
    Type: Application
    Filed: September 20, 2018
    Publication date: August 29, 2019
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20190000845
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: February 23, 2018
    Publication date: January 3, 2019
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • Phenyloxadiazole derivatives as PGDS inhibitors
    Patent number: 9937175
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: April 10, 2018
    Assignee: Sanofi
    Inventor: Christopher L. VanDeusen
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20170231990
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: September 7, 2016
    Publication date: August 17, 2017
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • Phenyloxadiazole derivatives as PGDS inhibitors
    Patent number: 9469627
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: October 18, 2016
    Assignee: Sanofi
    Inventors: Christopher L. Vandeusen, Franz J. Weiberth, Harpal S. Gill, George Lee, Andrea Hillegass
  • PHENYLOXADIAZOLE DERIVATIVES AS PGDS INHIBITORS
    Publication number: 20120190695
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).
    Type: Application
    Filed: April 4, 2012
    Publication date: July 26, 2012
    Applicant: SANOFI
    Inventors: Christopher L. VANDEUSEN, Franz J. WEIBERTH, Harpal S. GILL, George LEE, Andrea HILLEGASS
  • Transporters Comprising Spaced Arginine Moieties
    Publication number: 20100081618
    Abstract: The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
    Type: Application
    Filed: September 3, 2009
    Publication date: April 1, 2010
    Inventors: Paul A. Wender, Jonathan B. Rothbard, Lee Wright, Erik L. Kreider, Christopher L. VanDeusen
  • PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS
    Publication number: 20100048568
    Abstract: This invention is directed to a compound of formula (I): wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: September 30, 2009
    Publication date: February 25, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Suzanne C. Aldous, Michael W. Fennie, John Z. Jiang, Stanly John, Lan Mu, Brian Pedgrift, James R. Pribish, Barbara Rauckman, Jeffrey S. Sabol, Grzegorz T. Stoklosa, Sukanthini Thurairatnam, Christopher L. Vandeusen
  • Transporters comprising spaced arginine moieties
    Patent number: 7585834
    Abstract: The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: September 8, 2009
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Cellgate, Inc.
    Inventors: Paul A. Wender, Jonathan B. Rothbard, Lee Wright, Erik L. Kreider, Christopher L. VanDeusen
  • Bi-directional synthesis of oligoguanidine transport agents
    Patent number: 7067698
    Abstract: Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ?-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 27, 2006
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paul A. Wender, Christopher L. VanDeusen, Kanaka Pattabiraman, Erin T. Pelkey, Theodore C. Jessop
  • Bi-directional synthesis of oligoguanidine transport agents
    Publication number: 20030073807
    Abstract: Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of &ohgr;-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.
    Type: Application
    Filed: August 2, 2002
    Publication date: April 17, 2003
    Inventors: Paul A. Wender, Christopher L. VanDeusen, Kanaka Pattabiraman, Erin T. Pelkey, Theodore C. Jessop