Abstract: A carpal tunnel syndrome wrist brace including a shell having a first and second edge lined with a plurality of eyelets and both edges being connected together by a tongue stitched therebetween. The shell includes a thumb hole for receiving a thumb and is shaped to fit a patient's wrist such that the patient can insert the hand and wrist into the proximal end of the shell and extend four fingers through the distal end of the shell with the thumb through the thumb hole. The shell is then secured to the patient's wrist to activate immobilization of the wrist using a pair of hook and loop fasteners and a plurality of laces.