Abstract: The invention relates to genetically modified arenaviruses suitable for the treatment of neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus, wherein the arenavirus has been engineered to include a nucleotide sequence encoding one or more antigenic fragment(s) of mutant KRAS alone or to further include a nucleotide sequence encoding one or more antigenic fragment(s) of a mutated cancer driver gene (e.g., a mutant TP53) or a tumor-associated antigen.

Abstract: The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: The present invention relates to bispecific antibodies comprising a first antigen binding site specific for a death receptor and a second antigen binding site specific for a second antigen, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: An endodontic instrument for root canal treatment is provided having a working portion manipulated by a handle and a connection assembly for attachment with an electronic apex locator. The connection assembly allows the electronic apex locator to be connected to the instrument at or through the coronal end of the handle. Preferably, the connection assembly includes a male/female assembly located within or on the surface the file handle.

Abstract: An endodontic file comprising an elongated, flexible metal, the file having a working portion for cutting or abrading biological material, the working portion comprising a proximal portion and a distal portion, the proximal and distal portions having different cross-sectional flute or core patterns and associated cutting edges.

Abstract: An endodontic instrument for root canal treatment is provided having a working portion manipulated by a handle and a connection assembly for attachment with an electronic apex locator. The connection assembly allows the electronic apex locator to be connected to the instrument at or through the coronal end of the handle. Preferably, the connection assembly includes a male/female assembly located within or on the surface the file handle.