Patents by Inventor Christopher Landowski

Christopher Landowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11827891
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: November 28, 2023
    Assignee: VTT TECHNICAL RESEARCH CENTRE OF FINLAND LTD
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • MODIFIED FILAMENTOUS FUNGI FOR PRODUCTION OF EXOGENOUS PROTEINS
    Publication number: 20230313121
    Abstract: The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, having reduced activity or expression of KEX2 and/or ALP7, said filamentous fungi is capable of producing elevated amounts and stability of an exogenous protein.
    Type: Application
    Filed: May 13, 2021
    Publication date: October 5, 2023
    Inventors: Marika Vitikainen, Anne Huuskonen, Andriy Kovalchuk, Christopher Landowski, Ronen Tchelet, Mark Aaron Emalfarb, Markku Saloheimo
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20220290165
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 18, 2021
    Publication date: September 15, 2022
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Expression system for eukaryotic organisms
    Patent number: 11332750
    Abstract: The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, the core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, the synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising the systems, and methods for producing protein products in eukaryotic hosts.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: May 17, 2022
    Assignee: Teknologian Tutkimuskeskus VTT OY
    Inventors: Dominik Mojzita, Anssi Rantasalo, Jussi Jäntti, Christopher Landowski, Joosu Kuivanen
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11180767
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: November 23, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20210139922
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 13, 2021
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10988791
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: April 27, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200347426
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10731168
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 4, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10724063
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200087696
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 22, 2019
    Publication date: March 19, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10544440
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: January 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
    Patent number: 10513724
    Abstract: The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such as Trichoderma cells, wherein at least 90% (mol %), preferably at least 95% of the total neutral N-glycans of said produced recombinant glycoprotein are mammalian-like N-glycans. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutations that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s); ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase; iii. a recombinant polynucleotide for increasing ?1, 2 mannosidase activity;and, iv. a recombinant polynucleotide encoding said heterologous glycoprotein.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: December 24, 2019
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Anne Leppänen, Heidi Salminen, Jukka Hiltunen, Anne Kanerva, Annamari Heiskanen, Ann Westerholm-Parvinen, Georg Schmidt, Anne Huuskonen, Eero Mustalahti, Christopher Landowski, Markku Saloheimo, Juhani Saarinen, Benjamin Patrick Sommer, Ramon Wahl, Christian Ostermeier, Bernhard Helk
  • Multiple Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20190309338
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: March 11, 2019
    Publication date: October 10, 2019
    Applicants: Glykos Finland OY, Novartis AG
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10435731
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: October 8, 2019
    Assignee: Glykos Finland Oy
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Production of Glycoproteins Having Increased N-Glycosylation Site Occupancy
    Publication number: 20190276867
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins with increased N-glycosylation site occupancy in filamentous fungal cells, such as Trichoderma cells. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutation that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s), ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase, and iii. a polynucleotide encoding a heterologous glycoprotein, wherein said catalytic subunit of oligosaccharyl transferase is selected from Leishmania oligosaccharyl transferase catalytic subunits.
    Type: Application
    Filed: March 26, 2019
    Publication date: September 12, 2019
    Applicant: Glykos Finland Oy
    Inventors: Jari Natunen, Christopher Landowski, Markku Saloheimo, Christian Ostermeier, Benjamin Patrick Sommer, Ramon Wahl
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20190233831
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: January 18, 2019
    Publication date: August 1, 2019
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja PENTTILÄ, Markku Saloheimo
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10240159
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: March 26, 2019
    Assignee: Glykos Finland OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hanninen, Noora Salovuori, Merja Penttila, Markku Saloheimo
  • Expression system for eukaryotic organisms
    Publication number: 20180371468
    Abstract: The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, said core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, said synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising said systems, and methods for producing protein products in eukaryotic hosts.
    Type: Application
    Filed: February 21, 2017
    Publication date: December 27, 2018
    Applicant: Teknologian tutkimuskeskus VTT Oy
    Inventors: Dominik MOJZITA, Anssi RANTASALO, Jussi JÄNTTI, Christopher LANDOWSKI, Joosu KUIVANEN
  • Regulatory Protein Deficient Trichoderma Cells and Methods of Use Thereof
    Publication number: 20180215797
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 2, 2018
    Applicant: Glykos Finland OY
    Inventors: Christopher Landowski, Ann Westerholm-Parvinen, Markku Saloheimo