Abstract: The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. These techniques may be used to create animal or plant models of disease as well as to identify new targets for drug or pathogen screening.

Abstract: A computer-based system and method is provided which use multilevel hashing for lookup of a complex nested object (such as access control list) which has a plurality of nesting levels and each level has at least one element. Method stores representatives of a complex nested object in a data structure at locations determined by recursive multilevel hashing of the complex nested object elements. When needed, a match for an inputted complex nested object is determined by applying the same recursive multilevel hashing to the inputted complex nested object, as used during the storing of the complex nested object, and performing integer comparisons with hash values of the stored complex nested object.

Abstract: The invention relates to the use of high-throughput methods for gene targeting, recombination, phenotype screening and biovalidation of drug targets utilizing enhanced homologous recombination (EHR) techniques. These methods utilize robotically driven multichannel pipetters to perform liquid, particle, cell and organism handling, robotically controlled plate and sample handling platforms, magnetic probes and affinity probes to selectively capture nucleic acid hybrids, and thermally regulated plates or blocks for temperature controlled reactions.

Abstract: The present invention is directed to methods and systems for integrating the provision of genomics services and the production of genomics products. In one aspect of the invention, a method is provided for integrated genomic services comprising (a) receiving a first request from a customer, wherein said request comprises a first nucleic acid sequence, and an order for at least two genomics products or services; and (b) utilizing said nucleic acid sequence to provide said at least two genomics services or products.