Abstract: The invention provides new heterocyclic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: An apparatus may include a sense amplifier with a single column select transistor, a local input/output line selectively couplable to a first bit line through the column select transistor, and a read/write gap comprising at least a first transistor and a second transistor. The first transistor may be couplable to a read select signal and a complimentary local input/output line and the second transistor is couplable to the complimentary local input/output line and a global input/output line.

Abstract: Systems and methods are directed to generating content that is contextually relevant in a writing style of a user. In example embodiments, a plurality of logical inputs regarding a topic is received in bullet point format. A content generator generates draft content using machine learning (ML) models. The generating comprises identifying a writing style of the user by applying the plurality of logical inputs to a first ML model, determining a context and direction for the draft content using a second ML model, and based on the plurality of logical inputs, the identified writing style, and the context and direction, generating at least one paragraph of draft content in the writing style of the user that follows an outline associated with the bullet point format and comprises a same context and direction as the plurality of logical inputs. The draft content is then presented at a client device.

Abstract: Techniques and examples pertaining to a tracking method using a two-component tracking device are described. The tracking device includes two components paired with one another: a first component that is specific to a subject the tracking device is intended to track, and a second component that is generic. The second component is capable of establishing a wireless connection with a cellular network, as well as collecting location information of the second component itself. The tracking method involves receiving from the cellular network a set of requirements associated with the subject, and triggering an action based on the set of requirements and the location information collected. The tracking method enables tracking of multiple subjects without a pairing mistake. Namely, a mismatch between multiple subjects to be tracked and multiple tracking devices intended to track the subjects can be avoided.

Abstract: Provided herein is a system and method for a sensor housing that mitigates glare within the field-of-view and facilitates cleaning of a sensor lens. A sensor assembly may include: a sensor having a sensor lens and a field-of-view through the sensor lens; and a baffle defining a sensor lens aperture, where the field-of-view through the sensor lens is through the sensor lens aperture, where the baffle includes a series of concentric rings extending away from the sensor lens aperture and increasing in diameter as a distance from the sensor lens aperture increases. According to some embodiments, the series of concentric rings defines a viewing angle, where the viewing angle corresponds to the field-of-view of the sensor lens.

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

Abstract: An exemplary system for constructing data structures that can perform inferential reasoning to answer input queries may receive input data, extract and cluster entities in the input data into topic clusters, and for a first topic cluster construct a data structure comprising a plurality of nodes, wherein nodes of the data structure respectively represent a topic entity extracted from the input data and grouped into the first topic cluster, and wherein a first node of the data structure is associated with a second node of the data structure based on the first node and the second node respectively representing a first topic entity and a second topic entity associated in the input data with a common one of the one or more identified linguistic modalities. An exemplary system comprising the data structure may receive an input query and generate a response to the input query using the data structure.

Abstract: A computer system for multi-stage residual modeling for authorizing an online user is provided. The computer system is programmed to store a plurality of models for analyzing transactions including a first model and a second model; receive a plurality of authorization data associated with a user and a transaction associated with the user; execute in real-time the first model using the plurality of authorization data to receive a first output for the first model, wherein the first output is within an output range; determine a remainder from the first model based on the first output and the output range; execute the second model using the plurality of authorization data and the remainder to generate a second output; combine the first output and the second output to generate a final output; and return the final output for decisioning on whether to authorize the transaction.

Abstract: An inertial measurement unit (IMU). The IMU includes: a plurality of micro-electromechanical system (MEMS) sensors, each having an output; a memory for storing calibration coefficients separately for each of the plurality of MEMS sensors, blending weights for each of the plurality of MEMS sensors, and data blending instructions for blending the outputs of the plurality of MEMS sensors; and a processor, coupled to the memory and the plurality of MEMS sensors, configured to execute the data blending instructions to apply the calibration coefficients separately to each of the plurality of MEMS sensors and the blending weights to the outputs of the plurality of MEMS sensors to create a blended output for the IMU; wherein the blending weights are calculated based on a plurality of test parameters for the plurality of MEMS sensors using at least one of a harmonic and a geometric mean of the plurality of test parameters.

Abstract: A processing device receives an image and calculates a sharpness metric for a region of interest of the image. The processing device determines whether the sharpness metric satisfies a sharpness criterion, and one or more additional operations are performed responsive to determining that the sharpness metric satisfies the sharpness criterion.

Abstract: An optical element may be fabricated by applying foreign or attenuating material, for example, a copper material or a material that includes copper, to a silicon dioxide thin film to form a layer that exhibits extraordinary optical absorption in the infrared wavelength region of at or about 2500-4700 nanometers. The foreign material may comprise or include a transition metal. The optical element exhibits increased accuracy and sensitivity in the infrared wavelength region of at or about 2500-4700 nanometers. The at or about 2500-4700 nanometers absorption property of the optical element can be selectively tuned to any region within this at or about 2500-4700 nanometers wavelength region. The optical element may comprise multiple layers of varying thicknesses to further tune the optical element to one or more spectral bands. Such an optical element may be utilized in a formation fluid analysis tool or an eye protection device.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: Described are methods and compositions for clinically proven safe and effective treatment of ulcerative colitis according to the product label described herein, particularly moderately to severely active ulcerative colitis in patients who have had an inadequate response to or are intolerant of a conventional or existing therapy by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody.

Abstract: Apparatuses, systems, and methods for compensated sense amplifier with cross-coupled n-type transistors. A sense amplifier has a pair of p-type transistors coupled between a system voltage and respective first and second gut nodes. When a command signal is active, the p-type transistors are coupled in a diode fashion from the system voltage to the respective gut nodes. The amplifier also has a pair of n-type transistors which are cross coupled, where a first n-type transistor has a node coupled to the first gut node and a gate coupled to the second gut node and the second n-type transistor has a node coupled to the second gut node and a gate coupled to the first gut node. Each of the n-type transistors may have a separate current flowing through them and respective one of a pair of feedback transistors to a ground voltage.

Abstract: A patient interface to deliver a flow of air at a positive pressure with respect to ambient air pressure to an entrance to the patient's airways to ameliorate sleep disordered breathing includes a frame assembly and a cushion assembly configured to removably and repeatably connect to the frame assembly. The frame assembly and the cushion assembly form at least part of a plenum chamber pressurizable to a therapeutic pressure. The cushion assembly comprises a one-piece construction including a seal-forming structure configured to form a seal with a region of a patient's face surrounding the entrance to the patient's airways and a frame connection structure configured to removably and repeatably connect the cushion assembly to the frame assembly. The seal-forming structure comprises a first elastomeric material and the frame connection structure comprises a second elastomeric material, the first elastomeric material comprising a lower durometer or hardness than the second elastomeric material.

Abstract: A method of determining the identity of a petroleum coke sample including obtaining a nuclear magnetic resonance (NMR) measurement of the sample, determining a relaxation decay value of a fluid in the sample from the NMR measurement, comparing the relaxation decay value to relaxation decay values of known petroleum coke materials in a reference group to determine whether the petroleum coke is one of the known materials.