Abstract: The biological production of beta-hydroxyisovalerate (?HIV) using a non-natural microorganism. The non-natural microorganism for the biologically-derived ?HIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural microorganism can host a non-natural enzyme, such as the non-natural enzyme expressed in a yeast or bacteria, wherein the non-natural microorganism comprises an active ?HIV metabolic pathway for the production of ?HIV. The biological derivation of ?HIV eliminates toxic by-products and impurities that result from the chemical production of ?HIV, such that ?HIV produced by a non-natural microorganism prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.

Abstract: Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined hydrogel structure in situ, including interpenetrating (IPN) and semi-IPN hydrogels.

Abstract: The biological production of beta-hydroxyisovalerate (?HIV) using at least one non-natural enzyme. The non-natural enzyme for the biologically-derived ?HIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural enzyme having one or more modifications of substrate-specificity positions. The non-natural enzyme can be expressed in a microorganism, such as a yeast or bacteria, wherein the microorganism comprises an active ?HIV metabolic pathway for the production of ?HIV. Alternatively, the non-natural enzyme can be a ?HIV synthase used to produce ?HIV in a cell-free environment. The biological derivation of ?HIV eliminates toxic by-products and impurities that result from the chemical production of ?HIV, such that ?HIV produced by a non-natural enzyme prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.

Abstract: The biological production of beta-hydroxyisovalerate (?HIV) using a non-natural microorganism. The non-natural microorganism for the biologically-derived ?HIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural microorganism can host a non-natural enzyme, such as the non-natural enzyme expressed in a yeast or bacteria, wherein the non-natural microorganism comprises an active ?HIV metabolic pathway for the production of ?HIV. The biological derivation of ?HIV eliminates toxic by-products and impurities that result from the chemical production of ?HIV, such that ?HIV produced by a non-natural microorganism prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.

Abstract: Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.

Abstract: A munition includes a munition body containing explosive material. An electronic subsystem is active between release and detonation of the explosive material. One or more batteries are electrically connected to the electronic subsystem to provide power to the electronic subsystem prior to detonation. The one or more batteries are positioned adjacent to the explosive material to be accelerated outward as corresponding munition projectiles after detonation, increasing the effective payload of the munition by performing dual functions. In one or more embodiments, the explosive material is cylindrically shaped and longitudinally aligned in a warhead section of the munition body. The one or more batteries are annularly positioned on lateral surface of the explosive surface to form a cellular fragmenting structure. In a particular embodiments, the munition body is a missile body containing a rocket propulsion system and the electronic subsystem comprises a missile guidance system.

Abstract: A munition includes a munition body containing explosive material. An electronic subsystem is active between release and detonation of the explosive material. One or more batteries are electrically connected to the electronic subsystem to provide power to the electronic subsystem prior to detonation. The one or more batteries are positioned adjacent to the explosive material to be accelerated outward as corresponding munition projectiles after detonation, increasing the effective payload of the munition by performing dual functions. In one or more embodiments, the explosive material is cylindrically shaped and longitudinally aligned in a warhead section of the munition body. The one or more batteries are annularly positioned on lateral surface of the explosive surface to form a cellular fragmenting structure. In a particular embodiments, the munition body is a missile body containing a rocket propulsion system and the electronic subsystem comprises a missile guidance system.

Abstract: Exemplary methods, apparatuses, and systems receive an instruction to establish a rule to take an action on each email message received from a first email address, determine that the first email address is associated with contact data, determine that the contact data is associated with a second email address, and apply the rule to take the action on each email message received from the second email address.

Abstract: Tools are provided for locating changes in source code. More particularly, tools are provided for use with an integrated development environment having a source code management system for locating related changes in source code. Changed elements of target source code are located in a source code repository by acquiring a search term and by locating one or more references to changed elements of target source code containing the search term, wherein the located references are provided in order of the most recently changed located source code reference.

Abstract: A polymer having the following general formula: where, PU is a polymer chain comprising at least one polyurethane chain; n ranges from 0 to 8; and X, Y and Z, identical or different, are H-bonding sites. Also provided is a supramolecular polymer comprising units that form H-bonds with one another, wherein at least one of these units is a polymer according to the invention. The supramolecular polymer is useful as a hot melt adhesive, in rotational or slush molding, in injection molding, and in the manufacture of thermoplastic polyurethane foams. Further provided is a process for the preparation of the polymer on bench and commercial scales.

Abstract: A tape holding device that holds and protects a microcassette. The tape holding device includes a pair of opposing rails, a stop tab and a retention button for securing the microcassette to the device. The device further includes a pair of upper holes through which a clip can be inserted to secure the tape holding device to a file folder. The tape holding device also includes side holes that allow the device to be inserted onto two rings of a three-ring binder. The tape holding device further includes a groove that allows the device to be flexed up and provides a recess for accepting a binder clip. The tape holding device also includes retention flights so that allow a rubber band to secure the device to a file folder. The tape holding device further includes a message area.