Patents by Inventor Christopher Loose

Christopher Loose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for generating hair cells by downregulating FOXO
    Patent number: 11617745
    Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: April 4, 2023
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Melissa Hill-Drzewi
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY UPREGULATING JAG-1
    Publication number: 20220259559
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: September 24, 2021
    Publication date: August 18, 2022
    Inventors: Christopher LOOSE, Will MCLEAN, Megan S. HARRISON
  • PHARMACEUTICAL COMPOSITIONS COMPRISING OTIC THERAPEUTIC AGENTS AND RELATED METHODS
    Publication number: 20220192984
    Abstract: The present disclosure relates to pharmaceutical compositions (e.g., pre-lyophilized pharmaceutical compositions, lyophilized pharmaceutical compositions, and reconstituted solutions) comprising one or more otic therapeutic agents. The present disclosure also relates to methods of preparing the pharmaceutical compositions, and methods of using the pharmaceutical compositions for therapeutic purpose.
    Type: Application
    Filed: October 2, 2019
    Publication date: June 23, 2022
    Inventors: Will MCLEAN, Rajesh MANCHANDA, Snehal KHEDKAR, Richard A. STRONG, Jr., Ashley BANKS, Bradley TAIT, Christopher LOOSE
  • COMBINATION OF CHIR99021 AND VALPROIC ACID FOR TREATING HEARING LOSS
    Publication number: 20220175776
    Abstract: Provided herein are compound(s) for use in treating sensorineural hearing loss in a human patient, for example, hair cell regeneration agent(s) for use in treating sensorineural hearing loss in a human. Also provided are methods of treating sensorineural hearing loss in a human by administering certain compound(s), for example, hair cell regeneration agent(s).
    Type: Application
    Filed: April 8, 2020
    Publication date: June 9, 2022
    Applicant: Frequency Therapeutics, Inc.
    Inventors: Carl LEBEL, Jenna HERBY, Will MCLEAN, Ashley HINTON, Moraye BEAR, Christopher LOOSE
  • VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS
    Publication number: 20220133740
    Abstract: The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists. The present invention further provides kits for the same.
    Type: Application
    Filed: February 7, 2020
    Publication date: May 5, 2022
    Applicant: Frequency Therapeutics, Inc.
    Inventors: Will MCLEAN, Christopher LOOSE
  • THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
    Publication number: 20220096639
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
    Patent number: 11260130
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 1, 2022
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will Mclean, Megan Harrison, Michael R. Jirousek
  • Compositions and methods for generating hair cells by upregulating JAG-1
    Patent number: 11162071
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: November 2, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison
  • Thermoreversible compositions for administration of therapeutic agents
    Patent number: 11160868
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: November 2, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS
    Publication number: 20210300948
    Abstract: The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 30, 2021
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
  • SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: I
    Publication number: 20210260061
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: May 12, 2021
    Publication date: August 26, 2021
    Inventors: Christopher LOOSE, Will MCLEAN, Megan S. HARRISON, Michael R. JIROUSEK
  • 1H-pyrrole-2,5-dione compounds and methods of using same
    Patent number: 11066419
    Abstract: The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: July 20, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Bradley Tait, Rajesh Manchanda, Will Mclean
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I
    Patent number: 11033546
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 15, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING 2-PYRIMIDINYLAMINOETHYLAMINO-2-PYRIDYL BASED COMPOUNDS
    Publication number: 20210093635
    Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 2-pyrimidinylaminoethylamino-2-pyridyl moiety having a Formula I and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: May 12, 2020
    Publication date: April 1, 2021
    Applicant: Frequency Therapeutics, Inc.
    Inventors: Christopher LOOSE, Will MCLEAN, Melissa HILL-DRZEWI
  • 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME
    Publication number: 20200316089
    Abstract: The present disclosure relates to 1,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
  • METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION
    Publication number: 20200121681
    Abstract: The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
    Type: Application
    Filed: October 17, 2019
    Publication date: April 23, 2020
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan HARRISON, Sara STRECKER
  • METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION
    Publication number: 20200113913
    Abstract: The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
    Type: Application
    Filed: April 11, 2018
    Publication date: April 16, 2020
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan S. HARRISON, Sara STRECKER
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY DOWNREGULATING FOXO
    Publication number: 20200078350
    Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY UPREGULATING JAG-1
    Publication number: 20200080054
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher Loose, Will McLean, Megan Harrison
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY UPREGULATING PI3K
    Publication number: 20200080055
    Abstract: Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON