Abstract: A patient transfer apparatus is provided and includes a frame, a seat assembly coupled to the frame, and a track assembly coupled to the frame. The track assembly includes a moveable track for traversing stairs and a motor configured to drive the track. The apparatus further includes a control system. The control system includes a controller configured to control the motor and to adjust a speed of the apparatus based on an occupancy of the seat assembly upon traversing the stairs based on a current to the motor upon traversing stairs.

Abstract: A system for providing haptic feedback accompanying media content, the system comprising: an input unit configured to obtain one or more audio components of the media content; a classification unit configured to determine, from the one or more audio components, a most prominent audio component representative of a scene in the media content, and a haptics generation unit configured to generate an output haptics signal based on the most prominent audio component.

Abstract: A music generation apparatus for generating information indicative of a musical score for a game, the apparatus including communication circuitry to communicate with an entertainment device, the communication circuitry being configured to receive a request to generate a musical score for a game, and to receive one or more keywords output by the entertainment device during processing of the game, the one or more keywords being indicative of one or more of an action and/or a condition associated with a user playing the game and the game state. The music generation apparatus also comprises music generation circuitry responsive to the request and each of the one or more keywords to generate the information indicative of the musical score in dependence on that keyword. An entertainment device is also provided, as well as a system, methods and computer programs.

Abstract: The present disclosure describes methods of polyimide synthesis and polyimides made therefore. The method includes placing a tetracarboxylic compound and a solvent in a reaction vessel and adding a first amount of a diamine. The first amount of the diamine is not more than 99.5 mol % of the tetracarboxylic compound inside the reaction vessel. The method can include agitating the mixture and determining a viscosity of the mixture. The method can further include adding a second amount of the diamine. The last steps can be repeated until the viscosity increases to a target value. The target viscosity can be correlated to a peak weight-averaged molecular weight of the polyimide.

Abstract: A data processing apparatus includes storage circuitry to store animation data for a computer generated environment, the animation data specifying animations of animated objects of the computer generated environment for a period of time, selection circuitry to receive an animation data request and to select a portion of the animation data in dependence on the animation data request, and output circuitry to output the portion of the animation data.

Abstract: There is provided a data processing apparatus for generating one or more images of a virtual environment. The apparatus includes a rendering processor configured to render a first part of the one or more images; a communication processor configured to request, from a remote computing device, data for rendering a second part of the one or more images; and an output image processor configured to generate the one or more images for display at least in part based on the rendered first part of the one or more images and the data for rendering the second part of the one or more images.

Abstract: A handheld three-dimensional (3D) measuring system operates in a target mode and a geometry mode. In the target mode, a target-mode projector projects a first line of light onto an object, and a first illuminator sends light to markers on or near the object. A first camera captures an image of the first line of light and the illuminated markers. In the geometry mode, a geometry-mode projector projects onto the object a first multiplicity of lines, which are captured by the first camera and a second camera. One or more processors determines 3D coordinates in the target mode and the geometry mode.

Abstract: Provided are systems and methods for generating a three-dimensional model from an intra-oral optical coherence tomography scan.

Abstract: R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.

Abstract: The present disclosure relates to biosensors and methods of use thereof.

Abstract: A steering system may include a seat assembly, a frame assembly and a wheel. The frame assembly may include a steering tube that is rotatably disposed within a head tube with a cam at a top end and a pair of forks at a bottom end to which is coupled an axle of the wheel. An arm may be disposed on and rotatably coupled to the seat assembly, and rotatably coupled to a left armrest and right armrest. A steering rod may be coupled to the cam and to one of the arms, the left armrest or the right armrest, such that forward movement of one of the armrests causes the steering rod to be translated forward and the cam to rotate in one direction, and backward movement of the same armrest causes the steering rod to be translated backward and the cam to rotate in an opposite direction.

Abstract: A steering system may include a seat assembly, a frame assembly and a wheel. The frame assembly may include a steering tube that is rotatably disposed within a head tube with a cam at a top end and a pair of forks at a bottom end to which is coupled an axle of the wheel. An arm may be disposed on and rotatably coupled to the seat assembly, and rotatably coupled to a left armrest and right armrest. A steering rod may be coupled to the cam and to one of the arms, the left armrest or the right armrest, such that forward movement of one of the armrests causes the steering rod to be translated forward and the cam to rotate in one direction, and backward movement of the same armrest causes the steering rod to be translated backward and the cam to rotate in an opposite direction.

Abstract: A valve assembly for an exhaust gas recirculation system includes a housing defining an inlet bore and including a second interior surface defining a housing bore. The valve assembly also includes a valve seat and a valve. The valve includes a valve stem and a valve sealing member. The valve assembly optionally includes a baffle at least partially disposed in the housing bore. A first interior radius is defined between the valve stem and the second interior surface. A second interior radius is defined between at least one of the valve stem and the second interior surface, the valve stem and the baffle, and the baffle and the second interior surface. The second interior radius is different from the first interior radius and is configured to direct the flow of the exhaust gas in the housing bore to reduce swirl of exhaust gas in the housing bore.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Disclosed herein are DNA origami nanostmcture that can be functionalized for personalized and targeted drug delivery. The disclosed nanostructures enter cells through the endolysosomal pathway and circumvent drug resistance mechanisms in target cells. The disclosed nanostructures can be loaded small molecule drugs (e.g. anthracyclines, anti-metabolites) and nucleic acids (e.g. antisense oligonucleotides, siRNA, miRNA) with targeting and/or therapeutic antibodies against tumor-specific antigens (e.g. anti-CD33, anti-CD20) that can be modified to treat to a wide range of cancers and ultimately tailored to specific patients' needs for precision medicine.

Abstract: Apparatus including a robotically controlled end effector having a compliant nosepiece that forms plies of a material onto contoured surfaces of a tool. The end effector includes a plurality of individually controllable rotary actuators which respectively control the position and compliancy of individual sections of the nosepiece in order to better conform the plies the contoured tool surfaces.

Abstract: Methods for performing inference on a generative model are provided. In one aspect, a method includes receiving a generative model in a probabilistic program form defining variables and probabilistic relationships between variables, and producing a neural network to model the behaviour of the generative model. The input layer includes nodes corresponding to the variables of the generative model, and the output layer includes nodes corresponding to a parameter of the conditional marginal of the variables of the input layer. The method also includes training the neural network using samples from the probabilistic program. A loss function is provided for each node of the output layer. The loss function for each output node is independent of the loss functions for the other nodes of the output layer. The method also includes performing amortised inference on the generative model. Systems and machine-readable media are also provided.

Abstract: Apparatus for forming composite plies on a contoured tool includes a forming head for forming the composite plies on the tool. The forming head is mounted on a manipulator and includes a compliant nosepiece adapted to conform to the contoured tool.