Patents by Inventor Christopher M. F. Semko

Christopher M. F. Semko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cathepsin and methods and compositions for inhibition thereof
    Patent number: 5858982
    Abstract: Methods for inhibiting the secretion of .beta.-amyloid peptide (.beta.AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in .beta.AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for .beta.AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: January 12, 1999
    Assignee: Athena Neurosciences, Inc.
    Inventors: Jay S. Tung, Sukanto Sinha, Christopher M. F. Semko
  • Cathepsin and methods and compositions for inhibition thereof
    Patent number: 5849711
    Abstract: Methods for inhibiting the secretion of .beta.-amyloid peptide (.beta.AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in .beta.AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for .beta.AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 15, 1998
    Assignee: Athena Neurosciences, Inc.
    Inventors: Jay S. Tung, Sukanto Sinha, Lisa McConlogue, Christopher M. F. Semko