Abstract: Vials and vial assemblies for storing a medicament in low temperature environments are provided. In one exemplary embodiment, a vial is provided that includes a base portion and a finish portion. The finish portion has an outer surface and an inner surface, in which the inner surface defines a channel that is configured to receive a first portion of a deformable sealing member. The finish portion on the outer surface thereof includes a surface feature that is configured to engage with a second portion of the deformable sealing member. The surface feature is configured to remain engaged with the second portion of the deformable sealing member when the deformable sealing member contracts from a first configuration to a second configuration, thereby maintaining a seal between the finish portion and the deformable sealing member.

Abstract: A closure device for use with a container having an open neck finish, including an inner cap having a skirt terminating in an open end which engages the outside diameter of the finish. The inner cap is sized to initially engage the finish. The skirt has circumferentially spaced slits extending, which may function as lyophilization ports, which permit the inner cap to expand upon an axial closing force and engage the bottom of the finish. A liner is positioned in the inner cap proximate the closed end and is compressed against the finish when the cap is moved to alignment with the bottom of the finish. An outer cap is locked on to the inner cap in pre-assembly which then encloses the inner cap after complete assembly to seal and compress the liner between the finish and the inside face of the inner cap.